Salvage Low-Dose-Rate Brachytherapy for Prostate Cancer Local Recurrence after Radical Prostatectomy: Our First three Patients

Gastaldi, Emilio; Gallo, Fabrizio; Chiono, Luciano; Giberti, Claudio

doi:10.5301/urologia.5000034

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…Improved biochemical relapse free survival occurs for lower Gleason score and pre-salvage PSA [27]. SBRACH is an effective salvage technique and can be considered in well selected patients allowing for dose escalation to-the nodular recurrence.This data confirmed the feasibility and safety of SBRACH when performed by experienced centers [28]. The disease control rates and complications of treatment compare very favorably with those reported using other modalities [29].…”

Section: Resultssupporting

confidence: 77%

Salvage Therapy for Prostate Cancer: Which is Best? Brachytherapy versus Open and Robotic Prostatectomy

Goonewardene¹

2016

J Nucl Med Radiat Ther

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Section: Resultssupporting

confidence: 77%

Salvage Therapy for Prostate Cancer: Which is Best? Brachytherapy versus Open and Robotic Prostatectomy

Goonewardene¹

2016

J Nucl Med Radiat Ther

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Salvage low-dose-rate brachytherapy for local recurrences after prostatectomy and adjuvant or salvage external beam irradiation: Feasibility study on five patients and literature review

et al. 2021

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PURPOSE: To assess the feasibility and tumor outcome of re-irradiation with low-dose-rate brachytherapy for macroscopic local recurrences after radical prostatectomy (RP) followed by adjuvant or salvage external beam radiation therapy (EBRT). METHODS AND MATERIALS: Between 2011 and 2018, five men with histologically proven local failure within the prostate (4) or seminal vesicle bed (1) after RP and adjuvant or salvage EBRT (median dose: 67.5 Gy) underwent a salvage brachytherapy (S-BT). The median delay after EBRT was 86 months (range 75e234). Two patients were castration-resistant at the time of S-BT. The gross tumor volume was defined on a multiparametric MRI and transrectal US imaging. Echoguided transperineal implants of Iodine-125 seeds were optimized with a per-operative dosimetry and delivered with the seed-selectron. RESULTS: A high conformity was achieved with a high dose to the CTV (D 95% O 145 Gy in all but one) and very low dose to the rectum, urethra, and bladder. With a median followup of 21 months, all but one patient experienced nodes and/or bone metastases. Local control was achieved in 3/4 of evaluable patients (local failure distant to the treated volume in one). To date, no Grade 2 or more late toxicities were observed. CONCLUSION: For selected patients, focal local recurrence brachytherapy after PR and EBRT appears technically feasible and safe, but the efficacy remains uncertain as the majority of patients quickly relapsed at other sites. Large prospective studies are still required to better select patients who will benefit from this strategy.

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Salvage Low-Dose-Rate Brachytherapy for Prostate Cancer Local Recurrence after Radical Prostatectomy: Our First three Patients

Cited by 2 publications

References 28 publications

Salvage Therapy for Prostate Cancer: Which is Best? Brachytherapy versus Open and Robotic Prostatectomy

Salvage Therapy for Prostate Cancer: Which is Best? Brachytherapy versus Open and Robotic Prostatectomy

Salvage low-dose-rate brachytherapy for local recurrences after prostatectomy and adjuvant or salvage external beam irradiation: Feasibility study on five patients and literature review

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