Salvage prostate brachytherapy for localized prostate cancer failure after external beam radiation therapy

Long-Term Outcome and Toxicity of Salvage Brachytherapy for Local Failure After Initial Radiotherapy for Prostate Cancer

“…The potential for treatment-related toxicity may be even higher in the setting of locally recurrent disease. Overall, the crude rate of serious complications (Grade $3) was 11% (4/37) in our study, which is lower than the rates published in some (3,9,12) but not all (10,13,14) recent salvage BT series with median follow-up ranging from 30 to 64 months. Men with a history of PLND had a higher risk of Grade $2 toxicity, indicating that careful patient selection could help improve the toxicity profile after salvage BT in the future.…”

“…Radical prostatectomy, cryotherapy, and brachytherapy have been attempted with varying degrees of success (1). Several series have been published in the literature describing the short-term and intermediate-term biochemical control of these potentially curative local approaches, but long-term outcomes and toxicity data are limited (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Herein we report the long-term oncologic and quality of life outcomes in a cohort of patients with locally recurrent prostate cancer treated with salvage brachytherapy.…”

Treatment outcome and toxicity after salvage 125-I implantation for prostate cancer recurrences after primary 125-I implantation and external beam radiotherapy

“…Overall survival was 93% after 5 years (21). Lee et al (2008) report an FFF rate (ASTRO definition, without backdating) after 5 years of 38% in 21 patients, with a 5-year overall survival rate of 81% (9). Considering the relatively small study groups, we should be careful comparing the existing literature with our data, but the FFF and survival rates seem to be following the same trends after 5 years' followup.…”

“…In addition, most of the serious complications occurred in the late phase, which is similar in our study. Other studies in the literature focus mainly on patients initially treated with external beam radiotherapy (9,21,22). Beyer (1999) studied 17 patients and reported an FFF rate (ASTRO definition) of 83% after 5 years for patients with low-to moderate-grade tumors and 30% for patients with high-grade tumors.…”

MR Imaging of Treated Prostate Cancer

“…To decrease the rates of morbidity, Eisenberg and Shinohara ( 70 ) proposed to reduce the treated volume of the prostate by applying a partial salvage procedure. Salvage brachytherapy is also a feasible option, with 5-year disease-free survival reported at 20%-67% (71)(72)(73). One important diffi culty regarding salvage brachytherapy remains dose determination, since repeat irradiation with 5-year disease-free survival reported at 47%-67% ( 59-63 ).…”