Salvia miltiorrhiza in thorax and abdomainal organ fibrosis: A review of its pharmacology

Abstract

Organ fibrosis is a common pathological change that finally results in organ failure, which involves the destruction of parenchyma cells, the activation of mesenchymal cells and the imbalance of immunological cells. In recent years, although some breakthroughs have been made in understanding the pathogenesis and therapeutics of organ fibrosis, no registered drugs could directly target the fibrotic process, which constitutes a major biomedical challenge. Salvia miltiorrhiza (SM) is a well-known medicinal plant in China, which has been widely applied because of its pharmacological effects on anti-oxidative, anti-myocardial infarction, anti-fibrotic, anti-inflammatory, and anti-neoplastic properties. Accumulated evidence suggested that SM played critical roles against organ fibrosis in vivo and in vitro experiments by its multiple biological compounds. In this review, we discussed the recent advances on the phytochemistry and pharmacological mechanisms of SM and its active ingredients in liver, lung, kidney, and heart fibrosis, which might help to promote the treatment of fibrotic diseases in thorax and abdomainal viscera in clinic.

Network pharmacology and molecular docking to explore the pharmacological mechanism of Yifei Tongluo granules in treating idiopathic pulmonary fibrosis: A review

“…[16,17] Various components of Danshen have antifibrotic effects. [18,19] DA and isorhamnetin are all present in Salvia miltiorrhiza. Isorhamnetin is a natural antioxidant that hinders the EMT process and endoplasmic reticulum stress by modulating the PERK signaling pathway to reduce bleomycin-induced pulmonary fibrosis in mice.…”

PPARG is a potential target of Tanshinone IIA in prostate cancer treatment: a combination study of molecular docking and dynamic simulation based on transcriptomic bioinformatics

“…Salvia miltiorrhiza (Danshen), a kind of famous traditional Chinese herb, is believed to treat diabetic angiopathy, organ fibrosis and Alzheimer's disease, and is widely and clinically applied by traditional Chinese medical care providers in the management of cardiovascular diseases, such as coronary artery disease [36][37][38]. Researchers have been extracting many promising chemical components, among which a series of lipophilic molecules named Tanshinone showed a great pharmacological potential [39].…”

Ethnobotanical, Phytochemical, and Pharmacological Properties of the Subfamily Nepetoideae (Lamiaceae) in Inflammatory Diseases

“…In the case of the genus Isodon, compounds with a Kaurano-type skeleton predominated, and some common cases among the species were adenanthine (C16), eriocalyxin B (C17), and oridonine (C18) [114,117,169]. Finally, the presence of triterpenes, such as oleanolic acid (19), ursolic acid (20), stigmasterol (21), and their derivatives, was very common in the subfamily Nepetoideae (Figure 7) [210][211][212]. Chemical structures of the representative bioactive metabolites are included in Figure 7.…”