Salvia miltiorrhiza in Treating Cardiovascular Diseases: A Review on Its Pharmacological and Clinical Applications

Ren, Jie; Fu, Li; Nile, Shivraj Hariram; Zhang, Jun; Kai, Guoyin

doi:10.3389/fphar.2019.00753

Cited by 233 publications

(138 citation statements)

References 154 publications

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“…The active compounds are mainly utilized as the dried root of the plant rhizome named Danshen (Gao et al, 2012). The plant bioactive compounds are the lipo-soluble Tanshinones and the water-soluble Phenolics (Ren et al, 2019). S. miltiorrhiza extracts have shown strong antioxidant capabilities with a high ability to scavenge free radicals, which seems the base of its strong cardio-and vascular-protective potential (Zhao et al, 2006).…”

Section: Herbal Medicine Management Of Atherosclerosis and Hypertensionmentioning

confidence: 99%

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

et al. 2020

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Cardiovascular diseases (CVDs) are a significant health burden with an ever-increasing prevalence. They remain the leading causes of morbidity and mortality worldwide. The use of medicinal herbs continues to be an alternative treatment approach for several diseases including CVDs. Currently, there is an unprecedented drive for the use of herbal preparations in modern medicinal systems. This drive is powered by several aspects, prime among which are their cost-effective therapeutic promise compared to standard modern therapies and the general belief that they are safe. Nonetheless, the claimed safety of herbal preparations yet remains to be properly tested. Consequently, public awareness should be raised regarding medicinal herbs safety, toxicity, potentially lifethreatening adverse effects, and possible herb-drug interactions. Over the years, laboratory data have shown that medicinal herbs may have therapeutic value in CVDs as they can interfere with several CVD risk factors. Accordingly, there have been many attempts to move studies on medicinal herbs from the bench to the bedside, in order to effectively employ herbs in CVD treatments. In this review, we introduce CVDs and their risk factors. Then we overview the use of herbs for disease treatment in general and CVDs in particular. Further, data on the ethnopharmacological therapeutic potentials and medicinal properties against CVDs of four widely used plants, namely Ginseng, Ginkgo biloba, Ganoderma lucidum, and Gynostemma pentaphyllum, are gathered and reviewed. In particular, the employment of these four plants in the context of CVDs, such as myocardial infarction, hypertension, peripheral vascular diseases, coronary heart disease, cardiomyopathies, and dyslipidemias has been reviewed, analyzed, and critically discussed. We also endeavor to document the recent studies aimed to dissect the cellular and molecular cardio-protective mechanisms of the four plants, using recently reported in vitro and in vivo studies. Finally, we reviewed and reported the results of the

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Section: Herbal Medicine Management Of Atherosclerosis and Hypertensionmentioning

confidence: 99%

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

et al. 2020

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“…The potential therapeutic effect on AP was shown in a small sample clinical trial [5]. As one of the main active components of Salvia miltiorrhiza, Tanshinone IIA (TSA) has been found effective in many diseases, such as cardiovascular diseases, liver diseases, and cancer [6][7][8]. TSA has been broadly studied for its multiple pharmacological properties including antiangiogenic, antioxidant, anti-inflammatory, and anticancer activities [7,9,10].…”

Section: Introductionmentioning

confidence: 99%

Tanshinone IIA Protects against Acute Pancreatitis in Mice by Inhibiting Oxidative Stress via the Nrf2/ROS Pathway

Chen

Yuan

Lǚ

et al. 2020

Oxidative Medicine and Cellular Longevity

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Background. Danshen (Salvia miltiorrhiza Bunge) and its main active component Tanshinone IIA (TSA) are clinically used in China. However, the effects of TSA on acute pancreatitis (AP) and its potential mechanism have not been investigated. In this study, our objective was to investigate the protective effects of TSA against AP via three classic mouse models. Methods. Mouse models of AP were established by caerulein, sodium taurocholate, and L-arginine, separately. Pancreatic and pulmonary histopathological characteristics and serum amylase and lipase levels were evaluated, and changes in oxidative stress injury and the ultrastructure of acinar cells were observed. The reactive oxygen species (ROS) inhibitor N-Acetylcysteine (NAC) and nuclear factor erythroid 2-related factor 2 (Nrf2) knockout mice were applied to clarify the protective mechanism of the drug. Results. In the caerulein-induced AP model, TSA administration reduced serum amylase and lipase levels and ameliorated the histopathological manifestations of AP in pancreatic tissue. Additionally, TSA appreciably decreased ROS release, protected the structures of mitochondria and the endoplasmic reticulum, and increased the protein expression of Nrf2 and heme oxygenase 1 of pancreatic tissue. In addition, the protective effects of TSA against AP were counteracted by blocking the oxidative stress (NAC administration and Nrf2 knockout in mice). Furthermore, we found that TSA protects pancreatic tissue from damage and pancreatitis-associated lung injury in two additional mouse models induced by sodium taurocholate and by L-arginine. Conclusion. Our data confirmed the protective effects of TSA against AP in mice by inhibiting oxidative stress via the Nrf2/ROS pathway.

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“…It is well‐known that herbal therapy has been widely used in China and other Asian countries, for the treatment or the adjuvant treatment of various diseases, such as cardiovascular diseases, digestive disorders, liver diseases and various types of cancer. [ 24–29 ] In clinical settings, to get the best benefit for patients, herbal therapy is always used in combination with other therapeutic drugs in Chinese hospitals. The combination use of herbal medicines with therapeutic drugs has aroused significant safety concerns on the potential risks of herb–drug interactions (HDIs), among the patients and clinical pharmacologists.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetic interaction between a Chinese herbal formula Huosu Yangwei oral liquid and apatinib in vitro and in vivo

Fang

Huang

Zhang

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives This study aimed to evaluate the inhibitory effects of Huosu Yangwei oral liquid (HSYW) on cytochrome P450 enzymes (CYPs) and to investigate whether this herbal medicine could modulate the pharmacokinetic behaviour of the co-administered CYP-substrate drug apatinib. Methods Cytochrome P450 enzymes inhibition assays were conducted in human liver microsomes (HLM) by a LC-MS/MS method for simultaneous determination of the oxidative metabolites of eight probe substrates for hepatic CYPs. The modulatory effects of HSYW on the oxidative metabolism of apatinib were investigated in both HLM and rat liver microsomes (RLM). The influences of HSYW on the pharmacokinetic behaviour of apatinib were investigated in rats. Key findings Huosu Yangwei oral liquid inhibited all tested CYPs in human liver preparations, with the IC 50 values ranged from 0.3148 to 2.642 mg/ml. HSYW could also inhibit the formation of two major oxidative metabolites of apatinib in liver microsomes from both human and rat. In-vivo assays demonstrated that HSYW could significantly prolong the plasma half-life of apatinib by 7.4-fold and increase the AUC 0-inf (nMÁh) of apatinib by 43%, when HSYW (10 ml/kg) was co-administered with apatinib (10 mg/kg) in rats. Conclusions Huosu Yangwei oral liquid could inhibit mammalian CYPs and modulated the metabolic half-life of apatinib both in vitro and in vivo.

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Salvia miltiorrhiza in Treating Cardiovascular Diseases: A Review on Its Pharmacological and Clinical Applications

Cited by 233 publications

References 154 publications

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

Tanshinone IIA Protects against Acute Pancreatitis in Mice by Inhibiting Oxidative Stress via the Nrf2/ROS Pathway

Pharmacokinetic interaction between a Chinese herbal formula Huosu Yangwei oral liquid and apatinib in vitro and in vivo

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