Salvianolic Acids for Injection Combined with Conventional Treatment for Patients with Acute Cerebral Infarction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Abstract

BackgroundThis meta-analysis was conducted to evaluate the clinical effectiveness and safety of Salvianolic acids for injection (SAFI) plus conventional treatment (CT) for patients with acute cerebral infarction (ACI) and to assess the evidence to guide clinical practice.Material/MethodsPubMed, EMBASE, Cochrane Library, Web of Science, and 4 Chinese electronic databases were searched to identify relevant randomized controlled trials (RCTs). The methodological quality of eligible studies was evaluated using the Cochrane risk of bias tool. The reporting quality of eligible studies was evaluated by Consolidated Standards of Reporting Trials (CONSORT) for traditional Chinese medicine. Meta-analysis and evidence quality were performed using RevMan 5.3 and Grading of Recommendations Assessment, Development, and Evaluation (GRADE).ResultsA total of 14 RCTs involving 1309 patients were included. Meta-analysis showed that SAFI plus CT was better than CT alone in improving the total effective rate (RR=1.35, 95% CI 1.25 to 1.44, P<0.00001), reducing the National Institutes of Health Stroke Scale (NIHSS) score (130 mg: WMD=−3.31, 95% CI −3.80 to −2.47, P<0.00001; 100 mg: WMD=−1.91, 95% CI −2.28 to −1.54, P<0.00001), improving the activity of daily living and cognitive function of ACI, and improving the hemorheology (HBV: high shear rate blood viscosity, LBV: low shear rate blood viscosity, PV: plasma viscosity) and C-reactive protein (CRP).ConclusionsSAFI plus CT in the treatment of ACI can improve the total effective rate, neurological deficit, and ability to perform activities of daily living, and there is no serious adverse reaction. Based on the GRADE system, the evidence quality is low. More large-scale, well-designed, and high-quality RCTs are required to confirm the positive results.

Edaravone Combined with Clopidogrel Is Beneficial to Improve Efficacy, Neurological Impairment, and Life Function in Acute Cerebral Infarction Patients

“…Acute cerebral infarction (ACI) is an ischemic disease caused by cerebral vascular occlusion or stenosis, which can lead to brain injury and neurological deficit [1]. It has extremely high mortality, disability, and morbidity [2]. And it is the second most fatal disease in the world [3].…”

Interaction study of salvianolic acids for injection on pharmacokinetics of clopidogrel in rats using LC–MS/MS

“…Salvianolic acids for injection (SAI) is mainly made from water‐soluble components of Salvia miltiorrhiza Bunge, which was approved by National Medical Products Administration (NMPA) of China in 2011 for the treatment of cardiovascular and cerebrovascular diseases, especially ischemic stroke (Li, Polachi, et al, 2018; Lyu et al, 2019; Ma et al, 2021). In recent studies, SAI has been shown to improve ischemia/reperfusion (I/R)–induced microcirculation disturbances, which are associated with the inhibition of oxygen free radical production (Ma et al, 2021; Wang et al, 2010).…”

Magnetic Resonance Imaging Image Segmentation Under Artificial Intelligence Neural Network for Evaluation of the Effect of Butyphthalide Combined With Edaravone on Neurological Function in Patients With Acute Cerebral Infarction

“…Acute cerebral infarction refers to the sudden interruption of blood supply in the brain, which then leads to the necrosis of brain tissue (Lyu et al, 2019 ). The onset of the disease is sudden, usually during quiet rest or sleep, and the onset peaks in a few hours or within 1 to 2 days.…”