Same-admission versus interval cholecystectomy for mild gallstone pancreatitis (PONCHO): a multicentre randomised controlled trial

Early laparoscopic cholecystectomy following acute biliary pancreatitis expedites recovery

“…[27] However, it was significantly longer in group 2 of our study. The reason for this may be that episode count and duration from onset to surgery is significantly higher in this group (Table 1).…”

“…The primary endpoint was a composite of gallstone-related complications or mortality occurring within 6 months of randomization before or after cholecystectomy. [27] Readmission rate due to gallstone-related complications or mortality in the interval cholecystectomy group was reported as 17%. According to our study, readmission rate due to recurrent pancreatitis episodes in group 2 was 18%.…”

Cholecystectomy in mild acute biliary pancreatitis: The sooner; the better

“…It is worth pointing out that endoscopic retrograde cholangio-pancreatography was performed in 22% of patients, a figure similar to that in the Da Costa study, and inferior to the 39% reported by Van Baal (3,7). In this subgroup of patients, Bejarano et al report no cases of recurrence of the pancreatitis, while Da Costa found a relapse rate of 17%.…”

“…The authors prospectively study the recurrence of pancreatitis and biliary complications in a cohort of 282 patients with ABP, in whom cholecystectomy was delayed (median: 97 days, P 25 60 -P 75 173), and report recurrence of the pancreatitis in 46 patients (15.5%) and of biliary complications in 29 patients (9.7%) with a readmission rate of 27.3%, an incidence higher than the 17% reported by Da Costa and other authors, perhaps because the delay was greater (median: 97 days) (7).…”

“…There are only two prospective randomized trials comparing early and delayed cholecystectomy although each had different objectives (6,7).…”