Sampling volume assessment for wearable multimodal optical diagnostic device

Zharkikh, Elena V.; Dremin, Viktor; Dunaev, Andrey V.

doi:10.1002/jbio.202300139

Cited by 4 publications

(1 citation statement)

References 56 publications

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“…Limited depth penetration: Wearable LDF devices typically have shallow depth penetration. According to Zharkikh et al., 14 who investigated the depth sensitivity of LDF, the method typically achieves a penetration depth of more than 2 mm, with a source-detector separation of more than 1 mm. This limitation may restrict their ability to measure microcirculation and hinder the assessment of perfusion in deeper tissues, which can be relevant in certain clinical scenarios.…”

Section: Introductionmentioning

confidence: 99%

Wearable laser Doppler flowmetry for non-invasive assessment of diabetic foot microcirculation: methodological considerations and clinical implications

Hu,

Xing,

Zhang

et al. 2024

J. Biomed. Opt.

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. Significance Type 2 diabetes mellitus (T2DM) is a global health concern with significant implications for vascular health. The current evaluation methods cannot achieve effective, portable, and quantitative evaluation of foot microcirculation. Aim We aim to use a wearable device laser Doppler flowmetry (LDF) to evaluate the foot microcirculation of T2DM patients at rest. Approach Eleven T2DM patients and twelve healthy subjects participated in this study. The wearable LDF was used to measure the blood flows (BFs) for regions of the first metatarsal head (M1), fifth metatarsal head (M5), heel, and dorsal foot. Typical wavelet analysis was used to decompose the five individual control mechanisms: endothelial, neurogenic, myogenic, respiratory, and heart components. The mean BF and sample entropy (SE) were calculated, and the differences between diabetic patients and healthy adults and among the four regions were compared. Results Diabetic patients showed significantly reduced mean BF in the neurogenic ( ) and heart ( ) components at the M1 and M5 regions ( ) compared with healthy adults. Diabetic patients had significantly lower SE in the neurogenic ( ) and myogenic ( ) components at the M1 region, as well as in the endothelial ( ) component at the M5 region and in the myogenic component at the dorsal foot ( ), compared with healthy adults. The SE in the myogenic component at the dorsal foot was lower than at the M5 region ( ) and heel area ( ). Similarly, the SE in the heart component at the dorsal foot was lower than at the M5 region ( ) and heel area ( ) in diabetic patients. Conclusions This study indicated the potential of using the novel wearable LDF device for tracking vascular complications and implementing targeted interventions in T2DM patients.

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Section: Introductionmentioning

confidence: 99%

Wearable laser Doppler flowmetry for non-invasive assessment of diabetic foot microcirculation: methodological considerations and clinical implications

Hu,

Xing,

Zhang

et al. 2024

J. Biomed. Opt.

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Microcirculatory Dysfunction in Patients With Diabetes Mellitus Detected by a Distributed System of Wearable Laser Doppler Flowmetry Analysers

Zharkikh,

Loktionova,

Dunaev

2024

Journal of Biophotonics

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The paper is devoted to the study of perfusion and amplitude‐frequency spectra of laser Doppler flowmetry (LDF) signals in patients with diabetes mellitus (DM) in different skin areas of the upper and lower extremities using a distributed system of wearable LDF analysers. LDF measurements were performed in the areas of the fingers, toes, wrists and shins. The mean perfusion values, the amplitudes of blood flow oscillations in endothelial, neurogenic, myogenic, respiratory and cardiac frequency ranges, and the values of nutritive blood flow were analysed. The results revealed a decrease in tissue perfusion and nutritive blood flow in the lower extremities and an increase in these parameters in the upper extremities in patients with DM. A decrease in the amplitudes of endothelial and neurogenic oscillations was observed. The obtained results confirm the possibility of using wearable LDF analysers to detect differences in the blood flow regulation in normal and pathological conditions.

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Reproducibility of Laser Doppler Flowmetry in gingival microcirculation. A study on six different protocols

Ajan,

Roberg,

Fredriksson

et al. 2024

Microvascular Research

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Sampling volume assessment for wearable multimodal optical diagnostic device

Cited by 4 publications

References 56 publications

Wearable laser Doppler flowmetry for non-invasive assessment of diabetic foot microcirculation: methodological considerations and clinical implications

Wearable laser Doppler flowmetry for non-invasive assessment of diabetic foot microcirculation: methodological considerations and clinical implications

Microcirculatory Dysfunction in Patients With Diabetes Mellitus Detected by a Distributed System of Wearable Laser Doppler Flowmetry Analysers

Reproducibility of Laser Doppler Flowmetry in gingival microcirculation. A study on six different protocols

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