Sanguisorba minor Scop.: An Overview of Its Phytochemistry and Biological Effects

Tocai (Moţoc), Alexandra Cristina; Kokeric, Tijana; Tripon, Septimiu; Barbu-Tudoran, Lucian; Barjaktarevic, Ana; Cupara, Snezana; Vicas, Simona Ioana

doi:10.3390/plants12112128

Cited by 8 publications

(6 citation statements)

References 77 publications

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“…Finally, it is particularly important here to mention that the content of bioactive compounds varies according to several factors including plant organ, phenological stage, growing regions, climatic patterns, and temperature. For instance, the aerial parts of S. minor (leaves and stems) have a high flavonoid content, with quercetin and ellagic acid being predominant, while they are less abundant in roots (Tocai Moţoc et al, 2023). The level of phenolic compounds during spring-summer seasons is higher than in other seasons, which may be related to the production of new current-year leaves (Karkanis et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats

Hosseini,

Ghorbani,

Alavi

et al. 2023

Front. Pharmacol.

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Introduction: Oxidative stress is a major instigator of various cardiovascular diseases, including myocardial infarction (MI). Despite available drugs, there is still an increased need to look for alternative therapies or identify new bioactive compounds. Sanguisorba minor (S. minor) is a native herb characterized by its potent antioxidant activity. This study was designed to evaluate the effect of S. minor against isoprenaline-induced MI.Methods: Rats were treated with the hydro-ethanolic extract of the aerial parts of S. minor at doses of 100 or 300 mg/kg orally for 9 days. Isoprenaline was injected subcutaneously at the dose of 85 mg/kg on days 8 and 9. Then, the activities of various cardiac injury markers including cardiac troponin (cTnT), lactate dehydrogenase (LDH), creatinine kinase muscle brain (CK-MB), creatinine phosphokinase (CPK), and antioxidant enzymes in serum were determined. Malondialdehyde (MDA) and thiol content were measured in cardiac tissue, and histopathological analysis was conducted.Results: Our results show that isoprenaline increased the serum levels of cTnT, LDH, CK-MB, and CPK (p < 0.001) and elevated MDA levels (p < 0.001) in cardiac tissue. Isoprenaline also reduced superoxide dismutase (SOD), catalase, and thiol content (p < 0.001). Importantly, the extract abolished isoprenaline-induced MI by elevating SOD and catalase (p < 0.001), reducing levels of MDA, and diminishing levels of cTnT, LDH, CK-MB, and CPK cardiac markers (p < 0.001). Histopathological studies of the cardiac tissue showed isoprenaline-induced injury that was significantly attenuated by the extract.Conclusion: Our results suggest that S. minor could abrogate isoprenaline-induced cardiac toxicity due to its ability to mitigate oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats

Hosseini,

Ghorbani,

Alavi

et al. 2023

Front. Pharmacol.

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“…There are flavonoids and tannins that have antimicrobial, antioxidant, and anti-inflammatory properties [80,81]. Punicalagin gallate and quercetinglucuronide are two well-known, potent antioxidant compounds; they provide protection from oxidative stress [12,13,82] and are present in S. minor Scop. roots, leaves, and flowers.…”

Section: Discussionmentioning

confidence: 99%

“…S. minor Scop., which belongs to the family of Rosaceae, is a perennial plant that commonly grows in most parts of Europe, North Africa, Asia, and America [7,8,[10][11][12][13][14]. Species of S. minor Scop.…”

Section: Introductionmentioning

confidence: 99%

“…can thrive in soils that are low in nutrients [18][19][20][21][22][23]. It has cold properties, tastes bitter and sour, and is non-toxic and fragrance-free [8,13].…”

Section: Introductionmentioning

confidence: 99%

“…has been used as a food ingredient because young leaves are edible and available all year round. The herb has a nutty flavor with a cucumber undertone [7,8,13,14].…”

Section: Introductionmentioning

confidence: 99%

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The Formulation of Dermato-Cosmetic Products Using Sanguisorba minor Scop. Extract with Powerful Antioxidant Capacities

Tocai (Moţoc),

Memete,

Ganea

et al. 2024

Cosmetics

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There has been a significant increase in the use of botanical resources for the formulation of topical products designed for medicinal and cosmetic applications. Sanguisorba minor Scop., a botanical species, exhibits a variety of properties and has significant potential for applications in the field of cosmetics. The aim of this study was to formulate topical preparations, incorporating an extract derived from the plant S. minor Scop. comprising a combination of roots, leaves, and flowers. In the initial phase, a total of seven combinations were prepared using extracts derived from the roots, leaves, and flowers of S. minor Scop. (v/v/v). These combinations were subsequently subjected to evaluation for their antioxidant capacity using four distinct methods: 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), cupric reducing antioxidant capacity (CUPRAC), and Trolox equivalent antioxidant capacity (TEAC). An extract of plant organs in a ratio of 1:2:1 (v/v/v), which had a strong antioxidant capacity and demonstrated synergistic effects according to the DPPH, TEAC, and CUPRAC assays (with values of 1.58 ± 0.1, 1.18 ± 0.09, and 1.07 ± 0.07, respectively), was selected for inclusion in three dermato-cosmetic products (hydrogel, emulgel, and cream). All the prepared preparations were evaluated in terms of topical formulation attributes and organoleptic characteristics. The testing of dermato-cosmetic products included assessments of their topical formulation properties and organoleptic characteristics. The hydrogel, emulgel, and cream exhibited varying degrees of stretchability. In addition, a study was carried out to assess the in vitro release of polyphenols from the cosmetic formulations using a Franz diffusion cell system. The results showed that the emulgel containing the extract of S. minor Scop. had the highest and most significant release of polyphenols, with a release rate of 84.39 ± 1.01%. This was followed by the hydrogel and cream, which had release percentages of 80.52 ± 0.89 and 75.88 ± 0.88, respectively, over an 8 h period. Thus, for the first time in the literature, a topical cosmetic product with high antioxidant potential containing S. minor Scop. extract was developed and optimized.

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Analysis of Sulfate Compounds From Sanguisorbae Radix and Its Major Metabolites in Rats by UPLC‐MS/MS and Molecular Docking

Wang,

Huo,

Han

et al. 2024

Rapid Comm Mass Spectrometry

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RationaleSanguisorbae Radix that mainly contains tannins and phenolic compounds has been widely used as a traditional Chinese medicine for treating hemafecia, hemorrhoids metrorrhagia and metrostaxis in clinics. However, there is no report about the sulfate phenolic compounds in Sanguisorbae Radix.MethodsExtraction of Sanguisorbae Radix was separated and purified by polyamide resin and octadecyl silane‐bonded silica, which were analyzed by HPLC‐IT‐TOF/MS. Analysis of rat plasma and urine samples using UPLC‐Q‐TOF/MS. Finally, the newly discovered sulfate esters in Sanguisorbae Radix were investigated by molecular docking to find out the linkage and the possible mechanism to psoriasis.ResultsThe chemical structures of methyl‐3‐O‐methylgallate‐5‐O‐sulfate and methyl‐3‐O‐methylgallate were elucidated by the spectral data of HRESIMS and NMR. In addition, 6 sulfate compounds were rapidly identified in Sanguisorbae Radix for the first time, among which 3 sulfate compounds were new natural products. Sixteen prototypes and 11 metabolites were found in rat plasma and urine samples, including 6 sulfate phenolic compounds, and their metabolic pathways in vivo were inferred. Molecular docking technique was used to validate the binding activity of methyl‐3‐O‐methylgallate‐5‐O‐sulfate to psoriasis‐related target proteins.ConclusionsIn this study, sulfate phenolic compounds with high content in Sanguisorbae Radix and biological samples were isolated and characterized by modern spectroscopic techniques, which may provide a theoretical basis for the study of the pharmacological activity and quality control of Sanguisorbae Radix and development of sulfate drugs with a similar structure.

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Sanguisorba minor Scop.: An Overview of Its Phytochemistry and Biological Effects

Cited by 8 publications

References 77 publications

Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats

Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats

The Formulation of Dermato-Cosmetic Products Using Sanguisorba minor Scop. Extract with Powerful Antioxidant Capacities

Analysis of Sulfate Compounds From Sanguisorbae Radix and Its Major Metabolites in Rats by UPLC‐MS/MS and Molecular Docking

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