Sappanwood (Caesalpinia sappan) Extract Gel Do Not Heal Skin Excisional Wound on Balb/c Mice

Abstract

Caesalpinia sappan has been studied for its biological activities in the wound healing process. Therefore, this study is conducted to investigate the wound healing activity of sappanwood extract in an excisional wound of Balb/c mice. Animal experiments were designated with, positive control group, negative control group, and three groups of treatment (G1, G2 and G3). The groups consist of povidone iodine ointment, blank gel, 5%, 30%, 90% concentration of sappanwood extract gel, respectively. All groups were applied topically on the surface of the biopsy wound once daily for 10 days. The wounds of the 2nd, 8th and 10th day of treatment were observed and measured. There was a significant difference from each group on day 2, 6 and 10 after wound induction (p=0,001, p=0,001 and p=0,006). The tendency of wound closure happened in positive group control, negative group control and G1. Negative control group showed the highest percentage of wound closure amongst all groups. Meanwhile, in G2 and G3 showed less percentage of closure and healing compared to the others. Despite there is a tendency of ethanolic C. sappan extract gels to the wound healing, administration of C. sappan extract gels topically do not heal the skin excisional wound.