Sarcoidosis and Psoriasis

Wanat, Karolyn A.; Schaffer, András; Richardson, Veronica; VanVoorhees, Abby; Rosenbach, Misha

doi:10.1001/jamadermatol.2013.4256

Cited by 36 publications

(17 citation statements)

References 16 publications

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“…Non-infectious granulomatous conditions such as granuloma annulare and sarcoidosis are rarely associated with psoriasis [98]. Th1 type cytokines are favored in the initial phase of sarcoidosis.…”

Section: Psoriasis and Granulomatous Diseasesmentioning

confidence: 99%

Psoriasis and Connective Tissue Diseases

Yamamoto

2020

IJMS

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Psoriasis is a chronic systemic inflammatory disease with various co-morbidities, having been recently considered as a comprehensive disease named psoriatic disease or psoriatic syndrome. Autoimmune diseases are one form of its co-morbidities. In addition to the genetic background, shared pathogenesis including innate immunity, neutrophil extracellular trap (NETs), and type I interferon, as well as acquitted immunity such as T helper-17 (Th17) related cytokines are speculated to play a significant role in both psoriasis and connective tissue diseases. On the other hand, there are definite differences between psoriasis and connective tissue diseases, such as their pathomechanisms and response to drugs. Therefore, we cannot expect that one stone kills two birds, and thus caution is necessary when considering whether the administered drug for one disease is effective or not for another disease. In this review, several connective tissue diseases and related diseases are discussed from the viewpoint of their coexistence with psoriasis.

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Section: Psoriasis and Granulomatous Diseasesmentioning

confidence: 99%

Psoriasis and Connective Tissue Diseases

Yamamoto

2020

IJMS

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“…Given the shared immunological pathways, coexistence of both conditions would be plausible as corroborated by reports and case series of patients with psoriasis and sarcoidosis 60 67–69Second, there is a paucity of clinical information on sarcoidosis, despite it being a multisystemic disease that can be debilitating and can result in morbidity if left untreated, that is, liver cirrhosis in patients with hepatic sarcoidosis and45 46 loss of vision in those with sarcoid uveitis 67. This lack of studies is particularly true for non-pulmonary and non-ocular sarcoidosis.We learnt important points about skeletal involvement of sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

Multisystemic sarcoidosis—important lessons learnt from one of the great imitators

2019

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We report a case of a woman who was admitted with a suspicion of metastatic malignancy of unknown primary origin. A few months prior to her admission, she presented to a rheumatologist with acute anterior uveitis, psoriasiform rashes and polyarthritis. A diagnosis of psoriatic arthropathy was made and she was treated accordingly. Soon after she presented with persistent back and right upper quadrant abdominal pain for which she had a CT scan done with evidence of hilar lymphadenopathy, liver hypodensities and lytic-sclerotic bone lesions. She was referred to our hospital for further investigations and management. After re-exploring her clinical presentation and further investigations (including a liver biopsy), a diagnosis of multisystemic sarcoidosis with ocular, reticuloendothelial, hepatic and skeletal involvement was made. The patient was started on systemic glucocorticoids and second line immunosuppressants and demonstrated significant clinical improvement with resolution of her liver granulomata on imaging and improvement in her back pain. The case illustrates the importance of a thorough clinical assessment, review of investigations and an open mind in the evaluation of a patient.

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“…Moreover, prior studies have demonstrated increased levels of interleukin (IL)-17 in bronchoalveolar lavage fluid and peripheral blood in these patients [9] . In view of the apparent overlap of immunoinflammatory mechanisms, interest in a possible correlation between psoriasis and sarcoidosis was recently rejuvenated after publication of the as yet largest case series consisting of 7 patients with concurrent psoriasis and sarcoidosis [11] – [13] . To the best of our knowledge, however, no large scale epidemiological study has previously been carried out to more definitively examine the association between these two diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Although the disease aetiology is poorly understood, the role of Th1- and Th17-mediated inflammation in formation of sarcoidal granulomas is well documented [8] – [10] . In view of this apparent pathogenic link between the two diseases it is interesting that limited case series have been presented with concurrent sarcoidosis and psoriasis [11] – [13] . However, no large scale epidemiological data exist on this topic and we therefore examined the association between sarcoidosis and psoriasis, including the impact of psoriasis severity, in a nationwide cohort.…”

Section: Introductionmentioning

confidence: 99%

Sarcoidosis in Patients with Psoriasis: A Population-Based Cohort Study

2014

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PurposePsoriasis is a chronic inflammatory disease characterized by a systemic immunological response which is mainly driven by activated T helper (Th) 1 and Th17 lymphocytes. Like psoriasis, sarcoidosis is a chronic inflammatory disorder with Th1/Th17-driven inflammation. Therefore, we investigated the risk of sarcoidosis in patients with psoriasis compared to the background population in a nationwide cohort.MethodsThe study included the entire Danish population aged ≥10 years followed from 1st January 1997 until diagnosis of sarcoidosis, death or 31st December 2011. Patients with a history of psoriasis and/or sarcoidosis at baseline were excluded. Information on comorbidity and concomitant medication was identified by individual-level linkage of administrative registers. Incidence rates of sarcoidosis were calculated and adjusted hazard ratios (HRs) were estimated by multivariable Cox regression models adjusted for age, gender, comorbidity, medications and socioeconomic status.ResultsA total of 6,043,518 subjects were eligible for analysis. In the study period 70,125 patients with new-onset psoriasis, including 11,834 patients with severe psoriasis, were identified. The overall incidence rates of sarcoidosis were 1.18, 2.22, and 4.06 per 10,000 person-years for the reference population (9,717 cases), mild psoriasis (78 cases) and severe psoriasis (22 cases), respectively. Compared to the reference population, the age- and gender-adjusted HRs for sarcoidosis were increased in patients with psoriasis with HR 1.49 (95% confidence interval [CI] 1.18–1.87) and HR 2.51 (CI 1.64–3.85) for those with mild and severe disease, respectively.ConclusionIn this nationwide cohort, psoriasis was associated with a disease severity-dependent increased risk of sarcoidosis.

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Sarcoidosis and Psoriasis

Cited by 36 publications

References 16 publications

Psoriasis and Connective Tissue Diseases

Psoriasis and Connective Tissue Diseases

Multisystemic sarcoidosis—important lessons learnt from one of the great imitators

Sarcoidosis in Patients with Psoriasis: A Population-Based Cohort Study

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