Sarcoidosis

Iannuzzi, Michael C.; Rybicki, Benjamin A.; Teirstein, Alvin S.

doi:10.1056/nejmra071714

Cited by 1,906 publications

(1,789 citation statements)

References 84 publications

Supporting

Mentioning

1,618

Contrasting

Unclassified

144

Order By: Relevance

“…Only 5% of patients with sarcoidosis present with cardiovascular manifestations attributable to cardiac sarcoidosis 4. However, biopsy‐proven cardiac sarcoidosis has been reported in up to 25% of asymptomatic sarcoidosis autopsy studies 5, 6. Patients with sarcoidosis with concomitant cardiovascular manifestations have more complications and a greater risk of sudden death 7, 8.…”

Section: Introductionmentioning

confidence: 99%

Hospitalization Rates, Prevalence of Cardiovascular Manifestations, and Outcomes Associated With Sarcoidosis in the United States

Patel

Kalra

Doshi

et al. 2018

JAHA

View full text Add to dashboard Cite

BackgroundRecent trends of hospitalizations and in‐hospital mortality are not well defined in sarcoidosis. We examined aforementioned trends and prevalence of cardiovascular manifestations and explored rates of implantable cardioverter‐defibrillator implantation in hospitalizations with sarcoidosis.Methods and ResultsUsing data from the National Inpatient Sample, a retrospective population cohort from 2005 to 2014 was studied. To identify sarcoidosis, an International Classification of Diseases, Ninth Revision, Clinical Modification (ICD‐9‐CM) diagnosis code was used. We excluded hospitalizations with myocardial infarction, coronary artery disease, and ischemic cardiomyopathy. Cardiovascular manifestations were defined by the presence of diagnosis codes for conduction disorders, arrhythmias, heart failure, nonischemic cardiomyopathy, and pulmonary hypertension. A total of 609 051 sarcoidosis hospitalizations were identified, with an age of 55±14 years, 67% women, and 50% black. The number of sarcoidosis hospitalizations increased from 2005 through 2014 (138 versus 175 per 100 000, P trend<0.001). We observed declining trends of unadjusted in‐hospital mortality (6.5 to 4.9 per 100 sarcoidosis hospitalizations, P trend<0.001). Overall ≈31% (n=188 438) of sarcoidosis hospitalizations had coexistent cardiovascular manifestations of one or more type. Heart failure (≈16%) and arrhythmias (≈15%) were the most prevalent cardiovascular manifestations. Rates of implantable cardioverter‐defibrillator placement were ≈7.5 per 1000 sarcoidosis hospitalizations (P trend=0.95) during the study period. Black race was associated with 21% increased risk of in‐hospital mortality (odds ratio, 1.21; 95% confidence interval, 1.16–1.27 [P<0.001]).ConclusionsSarcoidosis hospitalizations have increased over the past decade with a myriad of coexistent cardiovascular manifestations. Black race is a significant predictor of in‐hospital mortality, which is declining. Further efforts are needed to improve care in view of low implantable cardioverter‐defibrillator rates in sarcoidosis.

show abstract

Section: Introductionmentioning

confidence: 99%

Hospitalization Rates, Prevalence of Cardiovascular Manifestations, and Outcomes Associated With Sarcoidosis in the United States

Patel

Kalra

Doshi

et al. 2018

JAHA

View full text Add to dashboard Cite

show abstract

“…1,2 The spectrum of clinical symptoms of sarcoidosis is wide and related to the possible location of the lesions. 3 The clinical course and prognosis of the diseases is variable; acute forms including Lö fgren's syndrome (LS) resolve spontaneously in most cases.…”

Section: Introductionmentioning

confidence: 99%