Sarcoma botryoides in an infant

Sambeeck, Sam J. van; Mavinkurve‐Groothuis, Annelies M. C.; Flucke, Uta; Dors, Natasja

doi:10.1136/bcr-2013-202080

Cited by 6 publications

(5 citation statements)

References 2 publications

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“…In our case, IHC evaluation revealed positive anti-desmin antibody and positive anti-myogenin antibody. This finding was similar to a previous case report of sarcoma botryoides in a 17-month old infant, where IHC evaluation showed focal positivity for desmin and myogenin [2].…”

Section: Discussionsupporting

confidence: 91%

“…Since 1959, 7 cases of cervical ERMS in infants have been reported, including our patients [2,17–20]. From 6 previous reported cases, 2 of which were cases of recurrent ERMS, the earlier recurrent case was treated with chemotherapy and brachytherapy, while the later one was treated with surgery and chemotherapy [2,19]. However, the information written in the previous reported cases was incomplete.…”

Section: Discussionmentioning

confidence: 99%

“…This tumor typically presents as a “grape-like” tumor. It is usually reported as a vaginal tumor in the female reproductive tract of infants and rarely in the uterine cervix [2].…”

Section: Introductionmentioning

confidence: 99%

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Recurrent Cervical Sarcoma Botryoides in a 3-Year-Old Female: Approach in a Limited Resource Setting

et al. 2019

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Patient: Female, 3 Final Diagnosis: Recurrent sarcoma botryoides Symptoms: Vaginal mass Medication: — Clinical Procedure: Surgical resection • adjuvant chemotherapy Specialty: Obstetrics and Gynecology Objective: Unusual setting of medical care Background: Sarcoma botryoides, known as embryonal rhabdomyosarcoma (ERMS), is a malignant tumor which arises from embryonic muscle cells. The incidence of ERMS in the uterine cervix rarely occurs at a very young age. With sufficient resources, management of this disease is not difficult. However, in limited resources settings, such as in Indonesia, the situation is more challenging. This case report aims to highlight the difficulties encountered in diagnosing and treating patients with sarcoma botryoides. Case Report: A 3-year-old female patient came the outpatient clinic of our hospital with a protruding mass from her vagina resembling a bunch of grapes which easily bled. She underwent surgery to remove the mass. After the procedure, she did not return to the hospital for the recommended adjuvant chemotherapy treatment due to limited funds. Three months later, she came to the outpatient clinic with the same complaint, despite smaller size. Due to limited resources, we only evaluated the metastasis using chest x-ray and did not perform intra-operative biopsy. In the second surgery, a wide excision with 1–2 cm margin was performed, followed by adjuvant chemotherapy for 6 series. We achieved a satisfactory outcome in this case, and 18 months after the surgery, the patient was still in remission. Conclusions: Sarcoma botryoides is a rare malignancy. The effective treatment for sarcoma botryoides is wide excision with safe margin of 1–2 cm, followed by 6–12 cycles of vincristine, actinomycin D, and cyclophosphamide (VAC) regiment as an adjuvant chemotherapy. A family’s understanding of the treatment plan is important to achieve desired outcomes. Even with limited resources, this malignancy can still be properly treated.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Recurrent Cervical Sarcoma Botryoides in a 3-Year-Old Female: Approach in a Limited Resource Setting

et al. 2019

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“…These tumors are more aggressive and are usually ARMS [32]. Neonatal presentation of RMS is extremely rare with most cases presenting with the embryonal botryoid subtype [33].…”

Section: Presentationmentioning

confidence: 99%

Rhabdomyosarcoma and Extraosseous Ewing Sarcoma

Gurria

Dasgupta

2018

Children

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Rhabdomyosarcoma (RMS) is a malignant tumor that represents the most common form of pediatric soft tissue sarcoma. It arises from mesenchymal origin and forms part of the group of small round blue cell tumors of childhood. It has a constant annual incidence of 4.5 cases per 1,000,000 children. The known histological diagnosis of the two major subtypes (embryonal and alveolar) has been recently enhanced by tumor biological markers and molecular differentiation diagnostic tools that have improved not only the updated classification based on risk stratification, but also the treatment approach based on the clinical group. Ewing sarcoma (ES) is a round cell tumor, highly malignant and poorly differentiated that is currently the second most common malignant bone tumor in children. In rare instances, it develops from an extraskeletal origin, classified as extraosseous Ewing sarcoma (EES). We provide an updated, evidence-based and comprehensive review of the molecular diagnosis, clinical and diagnostic approach and a multidisciplinary medical and surgical management according to the latest standard of care for the treatment of pediatric RMS and EES.

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“…Characteristics and treatment of female patients with botryoid sarcoma[18,25,[27][28][29][30][31][32][33][34][35][36].…”

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confidence: 99%

Sarcoma Botryoides: Optimal Therapeutic Management and Prognosis of an Unfavorable Malignant Neoplasm of Female Children

et al. 2023

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Embryonal rhabdomyosarcoma (ERMS) is a rare malignancy and occurs primarily in the first two decades of life. Botryoid rhabdomyosarcoma is an aggressive subtype of ERMS that often manifests in the genital tract of female infants and children. Due to its rarity, the optimal treatment approach has been a matter of debate. We conducted a search in the PubMed database and supplemented it with a manual search to retrieve additional papers eligible for inclusion. We retrieved 13 case reports and case series, from which we summarized that the current trend is to approach each patient with a personalized treatment plan. This consists of a combination of local debulking surgery and adjuvant or neoadjuvant chemotherapy (NACT). Effort is made in every approach to avoid radiation for the sake of preserving fertility. Radical surgeries and radiation still have a role to play in extensive disease and in cases of relapse. Despite the rarity and aggressiveness of this tumor, disease-free survival and overall prognosis is excellent, especially when it is diagnosed early, compared with other subtypes of rhabdomyosarcoma (RMS). We conclude that the practice of a multidisciplinary approach is appropriate, with favorable outcomes; however, larger-scale studies need to be organized to have a definite consensus on optimal management.

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Sarcoma botryoides in an infant

Cited by 6 publications

References 2 publications

Recurrent Cervical Sarcoma Botryoides in a 3-Year-Old Female: Approach in a Limited Resource Setting

Recurrent Cervical Sarcoma Botryoides in a 3-Year-Old Female: Approach in a Limited Resource Setting

Rhabdomyosarcoma and Extraosseous Ewing Sarcoma

Sarcoma Botryoides: Optimal Therapeutic Management and Prognosis of an Unfavorable Malignant Neoplasm of Female Children

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