Sarcopenia and frailty in older patients with diabetes mellitus

Umegaki, Hiroyuki

doi:10.1111/ggi.12688

Cited by 138 publications

(118 citation statements)

References 81 publications

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“…Furthermore, emerging evidence suggests that sarcopenia is associated with many cardiometabolic diseases such as insulin resistance, diabetes mellitus, and cardiovascular disease. [3][4][5][6] Although decline in muscle mass is an inevitable process with aging, recent studies suggest that sarcopenia is a modifiable condition, and the rate of decline of muscle mass can be slowed by adopting a healthy lifestyle. The pathophysiology of sarcopenia is multifactorial.…”

Section: Introductionmentioning

confidence: 99%

Long Sleep Duration is Associated With Sarcopenia in Korean Adults Based on Data from the 2008–2011 KNHANES

Kwon

Jang

Park

et al. 2017

Journal of Clinical Sleep Medicine

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Study Objectives: Sarcopenia, or loss of muscle mass, occurs with aging and results in frailty, disability, cardiovascular disease, and insulin resistance. Recently, researchers have asserted that sarcopenia is not an inevitable process, but is a modifiable condition. Adequate sleep duration is also important to maintain good physical and mental health. Therefore, the aim of our study was to examine the association between sleep duration and sarcopenia in Korean adults. Methods: Data from 16,148 participants (7,158 men and 8,990 women) were analyzed from the 2008-2011 Korean National Health and Nutrition Examination Survey (KNHANES). We defined sarcopenia as one standard deviation below the sex-specific means of the appendicular skeletal muscle/height-squared values of a young reference group. Participants were categorized into 5 groups according to sleep duration. The odds ratios (OR) and 95% confidence intervals (95% CI) for sarcopenia according to sleep duration were calculated using multiple logistic regression analysis. Results: The prevalence of sarcopenia was 14.3% in the total population (males 18.7%, females 9.7%). Compared to the 7 hours of sleep group, the OR (95% CI) for sarcopenia of the long sleep duration group (9 hours or more) was 1.589 (1.100-2.295) after controlling for confounding factors. I NTRO DUCTI O NSarcopenia is a condition characterized by the loss of skeletal muscle mass, strength, and function.1 During normal aging in humans, muscle mass decreases by approximately 3% to 5% every 10 years after the age of 30 years.2 Especially in older people, sarcopenia is closely related to frailty, disability, and falls. Furthermore, emerging evidence suggests that sarcopenia is associated with many cardiometabolic diseases such as insulin resistance, diabetes mellitus, and cardiovascular disease.3-6 Although decline in muscle mass is an inevitable process with aging, recent studies suggest that sarcopenia is a modifiable condition, and the rate of decline of muscle mass can be slowed by adopting a healthy lifestyle. The pathophysiology of sarcopenia is multifactorial. Physical inactivity, low body weight, malnutrition, and a reduction in endocrine function have been identified as risk factors in several studies. 7,8An adequate amount of sleep plays an important role in physical health and quality of life. Therefore, researchers have tried to suggest an appropriate sleep duration. Although sleep duration varies across life span, the National Sleep Foundation has recommended that sleep duration be 7 to 8 hours. Considering the aforementioned findings, sarcopenia may be a detrimental preclinical condition that affects the relationship between sleep duration and adverse health outcomes. The association between sleep duration and sarcopenia has not been fully examined. Thus, in this study, we aimed to investigate the association between sleep duration and sarcopenia in Korea using a nationally representative dataset. M ETHO DS Study PopulationThe Korea National Health and Nutrition Examination Survey...

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Section: Introductionmentioning

confidence: 99%

Long Sleep Duration is Associated With Sarcopenia in Korean Adults Based on Data from the 2008–2011 KNHANES

Kwon

Jang

Park

et al. 2017

Journal of Clinical Sleep Medicine

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“…La sarcopenia acompaña frecuentemente a la diabetes mellitus (9). De hecho, se considera que tanto en el desarrollo de la sarcopenia como en la patogénesis de la diabetes mellitus pueden estar implicados mecanismos similares como la resistencia a la insulina, la inflamación crónica y la disfunción mitocondrial (1).…”

Section: Introductionunclassified

Relación entre calidad de vida, actividad física, alimentación, y control glucémico con la sarcopenia de adultos mayores con diabetes mellitus tipo 2.

Casals

Suárez-Cadenas

Carvajal³

et al. 2017

Nutr Hosp

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IntroducciónLa sarcopenia se define como la pérdida de masa muscular y su deterioro funcional asociado a la edad, por lo que tiene un alto impacto sobre la calidad de vida. Sin embargo, la prevalencia de la sarcopenia en diabetes mellitus tipo 2 (DM2) no está suficientemente estudiada.ObjetivosAnalizar la prevalencia de sarcopenia en mayores de 65 años con DM2 y la posible influencia de la actividad física, la alimentación, el control glucémico, el sexo, la edad y calidad de vida.MétodosParticiparon 279 pacientes (155 mujeres) de 76,6±6,27 años de edad. Se determinó el perímetro de cintura, cadera, pantorrilla y brazo, el índice de masa corporal, la fuerza de prensión manual, nivel de actividad física, el estado nutricional, la calidad de vida y el control glucémico. La sarcopenia se definió como un índice de masa muscular esquelética menor de 9,2 Kg/m2 en varones y menor de 7,4 Kg/m2 en mujeres.Resultados La prevalencia de sarcopenia en los participantes fue de un 8,33%. Hubo asociación negativa entre el nivel de sarcopenia y la calidad de vida (r =-0,130, p=0,030), actividad física (r= -0,164, p= 0,006), estado nutricional (r =-0,274, p=< 0,001), y sexo masculino (r= -0,137, p=0,022); y positiva para edad (r =0,183, p=0,002).ConclusionesLa prevalencia de la sarcopenia en DM2 es moderada. Se relaciona con importantes factores para la salud, como una menor calidad de vida, menor realización de ejercicio físico y mayor presencia de desnutrición, lo cual parece agravarse en adultos varones de edad avanzada.

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“…Age was also found to be another indicator of the response to the TW regimen. The reason for this is unclear, but aging is associated with a decrease of β-cell function [17][18][19][20] as well as progression of sarcopenia [21]. Thus, it is possible that both impaired insulin secretion and declining muscle insulin sensitivity may partly explain the instability of glucose levels in our patients over 80 years old.…”

Section: Discussionmentioning

confidence: 98%

Efficacy and safety of thrice-weekly insulin degludec in elderly patients with type 2 diabetes assessed by continuous glucose monitoring

et al. 2016

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Sarcopenia and frailty in older patients with diabetes mellitus

Cited by 138 publications

References 81 publications

Long Sleep Duration is Associated With Sarcopenia in Korean Adults Based on Data from the 2008–2011 KNHANES

Long Sleep Duration is Associated With Sarcopenia in Korean Adults Based on Data from the 2008–2011 KNHANES

Relación entre calidad de vida, actividad física, alimentación, y control glucémico con la sarcopenia de adultos mayores con diabetes mellitus tipo 2.

Efficacy and safety of thrice-weekly insulin degludec in elderly patients with type 2 diabetes assessed by continuous glucose monitoring

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