Sarcopenia in head and neck cancer

Abstract

CHAPTER 1General introduction Aim and outline of this thesis PART I IMAGE-BASED ANALYSIS OF SKELETAL MUSCLE MASS CHAPTER 2Validation of skeletal muscle mass assessment at the level of the third cervical vertebra in patients with head and neck cancer CHAPTER 3Agreement between skeletal muscle mass measurements using computed tomography imaging and magnetic resonance imaging in head and neck cancer patients CHAPTER 4The association of muscle segmentation of the musculus masseter and muscle segmentation at the level of the third cervical and lumbar vertebrae CHAPTER 5Cut-off values for low skeletal muscle mass at the level of C3 in patients with head and neck cancer PART II THE PREDICTIVE AND PROGNOSTIC IMPACT OF LOW SKELETAL MUSCLE MASS IN SURGICALLY TREATED HEAD AND NECK CANCER PATIENTS CHAPTER 6Low skeletal muscle mass is a strong predictive factor for surgical complications and prognostic factor for survival in oral cancer patients undergoing mandibular reconstruction with a free fibula flap CHAPTER 7Association of low skeletal muscle mass and systemic inflammation with surgical complications and survival after microvascular free flap head and neck reconstruction CHAPTER 8Are perioperative complications in patients operated for oral squamous cell carcinoma associated with low skeletal muscle mass? CHAPTER 9Arterial calcification and low skeletal muscle mass are independent risk factors for pharyngocutaeneous fistula formation after total laryngectomy PART III THE PREDICTIVE AND PROGNOSTIC IMPACT OF LOW SKELETAL MUSCLE MASS IN HEAD AND NECK CANCER PATIENTS TREATED WITH CHEMO-OR BIORADIOTHERAPY CHAPTER 10Image-based analysis of skeletal muscle mass predicts cisplatin dose-limiting toxicity in patients with locally advanced head and neck cancer CHAPTER 11Pre-treatment low skeletal muscle mass is associated with chemotherapy dose-limiting toxicity in head and neck cancer patients undergoing primary chemoradiotherapy with high dose cisplatin CHAPTER 12The predictive and prognostic value of low skeletal muscle mass for doselimiting toxicity and survival in head and neck cancer patients receiving concomitant cetuximab and radiotherapy CHAPTER 13The predictive value of low skeletal muscle mass assessed on cross-sectional imaging for anti-cancer drug toxicity: a systematic review and meta-analysis CHAPTER 14The association of cisplatin pharmacokinetics and skeletal muscle mass in head and neck cancer: the prospective PLATISMA study CHAPTER 15 Patterns, predictors and prognostic value of skeletal muscle mass loss in patients with locally advanced head and neck cancer undergoing cisplatinbased chemoradiotherapy CHAPTER 16Skeletal muscle mass is an imaging biomarker for decreased survival in patients with oropharyngeal squamous cell carcinoma CHAPTER 17Dysphagia, trismus and speech impairment following radiation-based treatment for advanced stage oropharyngeal carcinoma: a one-year prospective evaluation PART IV SARCOPENIA IN ELDERLY HEAD AND NECK CANCER PATIENTS CHAPTER 18Sarcopenia is a prognostic factor for overall survi...