Sarcopenia is a risk factor for cardiovascular events experienced by patients with critical limb ischemia

Matsubara, Yutaka; Matsumoto, Takuya; Inoue, Kentaro; Matsuda, Daisuke; Yoshiga, Ryosuke; Yoshiya, Keiji; Furuyama, Tadashi; Maehara, Yoshihiko

doi:10.1016/j.jvs.2016.09.030

Cited by 50 publications

(28 citation statements)

References 30 publications

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“…It has been reported, however, that a reduction of skeletal muscle mass is associated with MACLE in patients with PAD. 26 Although that study included only severe PAD patients with CLI, the present study extends these findings to include PAD patients with Fontaine class II-IV. In the present study, both psoas muscle CT value and psoas muscle area were decreased with advancing Fontaine class.…”

Section: Usefulness Of Intramuscular Fat Depositionmentioning

confidence: 59%

Decreased Psoas Muscle Computed Tomography Value Predicts Poor Outcome in Peripheral Artery Disease

Sugai

Watanabe

Otaki

et al. 2018

Circ J

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The purpose of this study was therefore to determine whether skeletal muscle mass and intramuscular fat deposition evaluated on CT can predict major adverse cardiovascular and limb events (MACLE) in patients with PAD. Methods Subjects This prospective study involved 327 consecutive patients admitted to the present hospital with PAD. PAD was diagnosed using the ankle brachial index (ABI) and contrast-enhanced CT. Endovascular therapy (EVT) was performed by experienced cardiologists according to the TransAtlantic Inter-Society Consensus II (TASC II) guideline recommendations. Fontaine classes II, III, and IV were defined as intermittent claudication, rest pain, and critical limb ischemia (CLI), respectively. Exclusion criteria included acute coronary syndrome (ACS) ≤3 months prior,

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Section: Usefulness Of Intramuscular Fat Depositionmentioning

confidence: 59%

Decreased Psoas Muscle Computed Tomography Value Predicts Poor Outcome in Peripheral Artery Disease

Sugai

Watanabe

Otaki

et al. 2018

Circ J

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“…Data extraction led to the evaluation of 140 publications, of which 87 met the inclusion criteria, and 79 were included in the final review. Of these, 18 gave sufficient data for epidemiological analysis and diagnostic criteria, [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] 33 gave sufficient data for mechanistical analysis, and 28 gave sufficient data for therapeutic approaches. 1/Epidemiological data: Is sarcopenia a rare condition in patients with PAD?…”

Section: Resultsmentioning

confidence: 99%

Sarcopenia and peripheral arterial disease: a systematic review

Pizzimenti

Meyer

Charles

et al. 2020

J cachexia sarcopenia muscle

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Background Patients with lower extremity peripheral arterial disease (PAD) and sarcopenia are a population at risk requiring specific and targeted care. The aim of this review is to gather all relevant studies associating sarcopenia and PAD and to identify the underlying pathophysiological mechanisms as well as potential therapeutic strategies to improve skeletal muscle function. Methods A systematic review was carried out following the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Results Data extraction allowed the evaluation of 140 publications; 87 met the inclusion criteria; of which 79 were included in the final review, reporting sufficient data for epidemiological and diagnostic criteria, mechanical analysis, and therapeutic approaches. Epidemiological analysis and diagnostic criteria were based on 18 studies following 2362 PAD patients [31.39% (SD 7.61) women], aged 72.42 (SD 2.84); sarcopenia was present in 34.63% (SD 12.86) of the patients. Mechanical and pathway analysis were based on five animal studies and 29 clinical reports, showing significantly altered muscle strength and function in 1352 PAD patients [26.49% (SD 17.32) women], aged 67.67 (SD 5.14) years; impaired muscle histology in 192 PAD patients (9.2% (SD 11.22) women), aged 64.3 (SD 0.99) years; +58.63% (SD 25.48) of oxidative stress in 69 PAD patients [16.96% (SD 8.10) women], aged 63.17 (SD 1.43) years; mitochondriopathy in 153 PAD patients [29.39% (SD 28.27) women], aged 63.50 (SD 1.83) years; +15.58% (SD 7.41) of inflammation in 900 PAD patients [40.77% (SD 3.71) women], aged 74.88 (SD 2.76) years; and altered signalling pathways in 51 PAD patients [34.45% (SD 32.23) women], aged 72.25 (SD 5.25) years. Therapeutic approaches analysis was based on seven animal studies and 21 clinical reports. In total, 884 patients followed an exercise therapy, and 18 received an angiogenesis treatment; 30.84% (SD 17.74) were women. Mean ages of patients studied were 66.85 (SD 3.96). Conclusions Sarcopenia and lower extremity PAD have musculoskeletal consequences that directly impair patients' quality of life and prognosis. Although PAD is primarily a vascular disease, all etiological factors of sarcopenia identified so far are present in PAD. Indeed, both sarcopenia and PAD are accompanied by oxidative stress, skeletal muscle mitochondrial impairments, inflammation, inhibition of specific pathways regulating muscle synthesis or protection (i.e. IGF-1, RISK, and SAFE), and activation of molecules associated with muscle degradation. To date, besides revascularization, the best therapeutic strategy includes exercise, but approaches targeting the underlying mechanisms still deserve further studies.

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“…Ischemia is the deprivation of blood supply; hence, tissues and the body parts are deprived of oxygen and nutrients ( Hunt et al, 1985 ; Mansfield et al, 1997 ; Madarame et al, 2013 ; Matsubara et al, 2015 ), and ischemia is typically caused by the narrowing or blockage of blood vessels or arteries. Reperfusion is the only intervention that can reliably reduce the infarct size in animals and humans ( Hale et al, 2013 ; Wei et al, 2016 ; Borges and Verdoorn, 2017 ; Misir et al, 2017 ; Sunagawa et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Chick Embryo: A Preclinical Model for Understanding Ischemia-Reperfusion Mechanism

et al. 2018

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Ischemia-reperfusion (I/R)-related disorders, such as stroke, myocardial infarction, and peripheral vascular disease, are among the most frequent causes of disease and death. Tissue injury or death may result from the initial ischemic insult, primarily determined by the magnitude and duration of the interruption in blood supply and then by the subsequent reperfusion-induced damage. Various in vitro and in vivo models are currently available to study I/R mechanism in the brain and other tissues. However, thus far, no in ovo I/R model has been reported for understanding the I/R mechanisms and for faster drug screening. Here, we developed an in ovo Hook model of I/R by occluding and releasing the right vitelline artery of a chick embryo at 72 h of development. To validate the model and elucidate various underlying survival and death mechanisms, we employed imaging (Doppler blood flow imaging), biochemical, and blotting techniques and evaluated the cell death mechanism: autophagy and inflammation caused by I/R. In conclusion, the present model is useful in parallel with established in vitro and in vivo I/R models to understand the mechanisms of I/R development and its treatment.

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Sarcopenia is a risk factor for cardiovascular events experienced by patients with critical limb ischemia

Abstract: Sarcopenia is a risk factor for worse cardiovascular event-free survival, and SAPT and statin therapy reduced this risk for patients with CLI. Furthermore, SAPT but not dual antiplatelet therapy increased cardiovascular event-free survival in patients with sarcopenia.

Cited by 50 publications

References 30 publications

Decreased Psoas Muscle Computed Tomography Value Predicts Poor Outcome in Peripheral Artery Disease

Decreased Psoas Muscle Computed Tomography Value Predicts Poor Outcome in Peripheral Artery Disease

Sarcopenia and peripheral arterial disease: a systematic review

Chick Embryo: A Preclinical Model for Understanding Ischemia-Reperfusion Mechanism

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