Sarcopenia is a risk factor for falling in independently living Japanese older adults: A 2‐year prospective cohort study of the GAINA study

Matsumoto, Hiromi; Tanimura, Chika; Tanishima, Shinji; Osaki, Mari; Noma, Hisashi; Hagino, Hiroshi

doi:10.1111/ggi.13047

Cited by 40 publications

(42 citation statements)

References 28 publications

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“…Four studies included a combined group of hospitalized patients with fractures and community‐dwelling individuals without fractures . Two studies reported retrospective data, 20 studies were cross‐sectional, 13 studies were prospective, and 1 study was a randomized controlled trial examining the effect of nutritional supplementation on bone mineral density and risk of falls . Most of the studies were performed in Europe (12 studies), and Asia (12 studies), followed by Australia (5 studies), South America (4 studies), and North America (3 studies) .…”

Section: Resultsmentioning

confidence: 99%

“…Online Resource S4 shows the results of the NOS quality assessment of the included studies. The quality of 12 falls studies and 14 fracture studies was rated high. Ten studies for falls were rated as low quality .…”

Section: Resultsmentioning

confidence: 99%

“…Twenty‐two studies investigated the association of sarcopenia and falls, of which 10 studies (45%) reported higher risks of falls among sarcopenic individuals compared with non‐sarcopenic individuals . Non‐significant associations between sarcopenia and falls were found in the remaining 12 studies …”

Section: Resultsmentioning

confidence: 99%

“…33,37,74 Four studies included a combined group of hospitalized patients with fractures and community-dwelling individuals without fractures. [29][30][31]51 Two studies reported retrospective data, 31,55 20 studies were crosssectional, 26,29,30,32,35,36,38,39,[41][42][43][44][48][49][50][51]54,72,73,75 13 studies were prospective, 18,25,27,28,33,34,37,40,[45][46][47]53,74 and 1 study was a randomized controlled trial examining the effect of nutritional supplementation on bone mineral density and risk of falls. 24 Most of the studies were performed in Europe (12 studies), 26,27,33,35,40,42,47,…”

Section: Search Resultsmentioning

confidence: 99%

“…The prevalence of sarcopenia varied from 0.3% to 73.0%, depending on the sarcopenia definition applied and the study population. Sarcopenia was diagnosed using one definition 18,26,[29][30][31][32][33][34][36][37][38][39][40][41][42][43][47][48][49][50]53,54,72,73,75 or more than one definition. 24,25,27,28,35,[44][45][46]51,55,74 Out of the 36 included studies, EWGSOP (23 studies) was the most commonly used definition, 24,25,28,[32][33][34][35][36][37][38][39][40][41][42]…”

Section: Search Resultsmentioning

confidence: 99%

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Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta‐analysis

Yeung

Reijnierse

Pham

et al. 2019

J cachexia sarcopenia muscle

643

463

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Sarcopenia is a potentially modifiable risk factor for falls and fractures in older adults, but the strength of the association between sarcopenia, falls, and fractures is unclear. This study aims to systematically assess the literature and perform a meta‐analysis of the association between sarcopenia with falls and fractures among older adults. A literature search was performed using MEDLINE, EMBASE, Cochrane, and CINAHL from inception to May 2018. Inclusion criteria were the following: published in English, mean/median age ≥ 65 years, sarcopenia diagnosis (based on definitions used by the original studies' authors), falls and/or fractures outcomes, and any study population. Pooled analyses were conducted of the associations of sarcopenia with falls and fractures, expressed in odds ratios (OR) and 95% confidence intervals (CIs). Subgroup analyses were performed by study design, population, sex, sarcopenia definition, continent, and study quality. Heterogeneity was assessed using the I 2 statistics. The search identified 2771 studies. Thirty‐six studies (52 838 individuals, 48.8% females, and mean age of the study populations ranging from 65.0 to 86.7 years) were included in the systematic review. Four studies reported on both falls and fractures. Ten out of 22 studies reported a significantly higher risk of falls in sarcopenic compared with non‐sarcopenic individuals; 11 out of 19 studies showed a significant positive association with fractures. Thirty‐three studies (45 926 individuals) were included in the meta‐analysis. Sarcopenic individuals had a significant higher risk of falls (cross‐sectional studies: OR 1.60; 95% CI 1.37–1.86, P < 0.001, I 2 = 34%; prospective studies: OR 1.89; 95% CI 1.33–2.68, P < 0.001, I 2 = 37%) and fractures (cross‐sectional studies: OR 1.84; 95% CI 1.30–2.62, P = 0.001, I 2 = 91%; prospective studies: OR 1.71; 95% CI 1.44–2.03, P = 0.011, I 2 = 0%) compared with non‐sarcopenic individuals. This was independent of study design, population, sex, sarcopenia definition, continent, and study quality. The positive association between sarcopenia with falls and fractures in older adults strengthens the need to invest in sarcopenia prevention and interventions to evaluate its effect on falls and fractures.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Search Resultsmentioning

confidence: 99%

Section: Search Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta‐analysis

Yeung

Reijnierse

Pham

et al. 2019

J cachexia sarcopenia muscle

643

463

View full text Add to dashboard Cite

show abstract

Association of cystatin C- and creatinine-based eGFR with osteoporotic fracture in Japanese postmenopausal women with osteoporosis: sarcopenia as risk for fracture

et al. 2018

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Coexistence of chronic kidney disease (CKD) is regarded as a risk for osteoporotic fracture particularly in postmenopausal women, not only because of increased parathyroid hormone level but also uremic sarcopenia. We examined the relationships of cystatin C-based glomerular filtration rate (eGFRcys) and creatinine-based GFR (eGFRcr), as well as their ratio with occurrence of osteoporotic fracture in postmenopausal osteoporotic women. This cross-sectional study included 555 postmenopausal women with osteoporosis. eGFRcr and eGFRcys were simultaneously measured, while occurrence of osteoporotic fracture was obtained by a medical chart review. Patients with osteoporotic fractures (n = 211) exhibited significantly lower levels of physical activity, eGFRcr, eGFRcys, and eGFRcys/eGFRcr ratios, while a higher percentage was CKD stage 3 or more, estimated by eGFRcr or eGFRcys (CKDcys), than those without (n = 344). Lower eGFRcys, but not lower eGFRcr, was independently associated with osteoporotic fracture in the entire cohort and that association was retained in CKDcys patients. Of great interest, higher eGFRcr was associated with osteoporotic fracture independent of eGFRcys in CKDcys patients. Furthermore, lower eGFRcys/eGFRcr ratio was independently associated with osteoporotic fracture in both CKDcys patients and the entire cohort. eGFRcys reduction might be associated with osteoporotic fracture in postmenopausal osteoporotic women, indicating the involvement of renal osteopathy in its occurrence. Furthermore, the association of higher, but not lower, eGFRcr with osteoporotic fracture in CKDcys cases might be explained by underestimation of renal dysfunction by eGFRcr resulting from decreased muscle mass and quality in those patients.

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Loss of height predicts fall risk in elderly Japanese: a prospective cohort study

et al. 2022

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Sarcopenia is a risk factor for falling in independently living Japanese older adults: A 2‐year prospective cohort study of the GAINA study

Abstract: The key finding of the present study suggests that sarcopenia is a risk factor for falling in older adults who are living independently even after adjustment for previous falls and confounding factors. Geriatr Gerontol Int 2017; 17: 2124-2130.

Cited by 40 publications

References 28 publications

Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta‐analysis

Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta‐analysis

Association of cystatin C- and creatinine-based eGFR with osteoporotic fracture in Japanese postmenopausal women with osteoporosis: sarcopenia as risk for fracture

Loss of height predicts fall risk in elderly Japanese: a prospective cohort study

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