Sarcopenia is as common in older patients with dementia with Lewy bodies as it is in those with Alzheimer's disease

Abstract

Alzheimer's disease (AD) and dementia with Lewy body (DLB) constitute the most common types of dementia, and are two common geriatric syndromes; however, sarcopenia has not been elaborately evaluated in DLB so far. Therefore, this study aimed to investigate the relationship between sarcopenia and DLB in older adults.Methods: In this retrospective and cross-sectional study, 662 participants, who were followed in a memory clinic at the Geriatrics department of a university hospital, were included. Comprehensive Geriatric Assessment, including the activities of daily living, malnutrition and malnutrition risk, frailty, cognition, and sarcopenia were assessed. Sarcopenia was defined according to the revised European Working Group on Sarcopenia in Older People-2 criteria.Results: A total of 662 participants (461 healthy controls, 133 with AD and 68 with DLB) with a mean age of 73.60 AE 7.50 years were included. The prevalence of probable sarcopenia and sarcopenia was 53.4% and 19.5%, respectively, in patients with AD, whereas it was 55.9% and 19.1%, respectively, in patients with DLB. After adjustment analyses, probable sarcopenia, sarcopenia and low muscle mass were related to AD (P < 0.001, P = 0.001, P < 0.001, respectively). Probable sarcopenia and slow gait speed were associated with DLB (P < 0.01, P < 0.001, respectively).Conclusions: Sarcopenia is common in patients with DLB and in those with AD, and seems to be closely related to low muscle strength and slow gait speed in DLB patients. Considering sarcopenia-related negative health outcomes in older adults, the evaluation of sarcopenia, therefore, should also be among the follow-up and treatment goals of DLB patients.

Neuroleptic Malignant Syndrome in Patients With Dementia: Experiences of A Single Memory Clinic

“…Given the potential to use antipsychotic, antiemetic, and antiparkinsonian drugs for various reasons in elderly patients, the risk of developing NMS should be considered. 16 Furthermore, given the limited neuronal reserve and frequency of comorbidities in the elderly, [17][18][19] NMS may have a worse prognosis in these patients. 5 In accordance with the literature, antipsychotic drugs were considered as the etiology of NMS in some of our cases.…”

Postprandial Hypotension Is More Common Than Orthostatic Hypotension In Older Adults With Dementia With Lewy Bodies: A Cross-Sectional Study

“…[8, 9, 14] However, to the best of our knowledge, this is the rst study to report the increased risk of PPH in DLB patients. Considering both DLB-related negative health outcomes, [9,13,21,29] and adverse events and complications related to OH and PPH, as signs of dysautonomia, it is clear that the prevention of such outcomes is indispensable to ensure better management of DLB. [8, 9,14] Although delayed OH was signi cantly higher in DLB patients than in control, this difference between the groups disappeared after the adjustment.…”

The Relationship Between Urinary Incontinence and Sarcopenia in Patients with Dementia

“…Örneğin bir çalışmada demansı olan kadın ve erkeklerde kalk ve yürü testinin demansı olmayanlara göre daha uzun olduğu ve ortalama el kavrama gücü ölçümlerinin EWGSOP-2'ye göre sarkopenik aralıkta olduğu dikkat çekmiştir 2 . Literatürde azalmış kas gücünün, bilişsel gerileme ve Alzheimer hastalığı (AH) ve Lewy cisimcikli demans ile negatif ilişkisini gösteren çalışmalar bildirilmiştir 9,26,27 . Chong ve ark.…”

“…Bu bireylerde en sık inkontinans tipi urge inkontinans iken, bunu mikst ve stres tip inkontinans takip etmektedir 8 . Bu bilgilere ek olarak literatürde demans ve sarkopeni ilişkisinin gösterildiği çalışmalar vardır 9,10 . Çağımızın korkulu rüyası olan demansın henüz kesin bir tedavisi yoktur ve semptomatik yaklaşımlar ön plandadır.…”