Sarcopenia is associated with disability status—results from the KORA-Age study

Phillips, Amanda; Strobl, Ralf; Vogt, Susanne; Ladwig, Karl‐Heinz; Thorand, Barbara; Grill, Eva

doi:10.1007/s00198-017-4027-y

Cited by 35 publications

(21 citation statements)

References 56 publications

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“…Morphometrics is a novel, objective, and comparably simple method to obtain a surrogate measure that allows one to assess an individual's overall health for surgery, as evidenced by its ability to predict outcomes and overall mortality[2329374354] and its association with functional status. [3640]…”

Section: Discussionmentioning

confidence: 99%

Morphometrics predicts overall survival in patients with multiple myeloma spine metastasis: A retrospective cohort study

Zakaria¹,

Elibe²,

Macki³

et al. 2018

Surg Neurol Int

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Background:Treatment strategies for spinal metastases for myeloma range from conservative measures (radiation and chemotherapy) to invasive (surgical). Identifying better predictors of overall survival (OS) would help in surgical decision making. Analytic morphometrics has been shown to predict survival in oncologic patients, and our study evaluates whether morphometrics is predictive of survival in patients with multiple myeloma (MM) spinal metastases.Methods:For this observational retrospective cohort study, we identified 46 patients with MM spinal metastases who had undergone stereotactic body radiation therapy. OS was the primary outcome measure. Morphometric analysis of the psoas muscle was performed using computed tomography scans of the lumbar spine.Results:OS was statistically correlated with age (P = 0.025), tumor burden (P = 0.023), and number of levels radiated (P = 0.029), but not with gender. Patients in the lowest tertile of average psoas size had significantly shorter survival compared to the highest tertile, hazard ratio (HZ) 6.87 (95% CI = 1.65–28.5, P = 0.008). When calculating the psoas size to vertebral body ratio and correlating this measure to OS, the lowest tertile again had significantly shorter OS compared to the highest tertile, HZ 6.87 (95% CI = 1.57–29.89, P = 0.010); the middle tertile also showed significantly shorter OS compared to the highest tertile, HZ 5.07 (95% CI = 1.34–19.10, P = 0.016). Kaplan–Meier survival curves were used to visually illustrate the differences in survival between different tertiles (Log-rank test P = 0.006).Conclusions:Morphometric analysis successfully predicts long-term survival in patients with MM. More research is needed to validate these results and to see if these methodologies can be applied to other cancer histologies.

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Section: Discussionmentioning

confidence: 99%

Morphometrics predicts overall survival in patients with multiple myeloma spine metastasis: A retrospective cohort study

Zakaria¹,

Elibe²,

Macki³

et al. 2018

Surg Neurol Int

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“…This increases the generalizability of the use of the sarcoscore among various community settings in Japan. Second, the sample size in the present study was relatively large compared to that of previous population-based studies which examined the associations between sarcopenia-related markers and functional disabilities in Australia [5], Italy [7], and Germany [49]. This minimizes the risk of β error and enables clearer identification of the strength of the association between the sarcoscore and the onset of functional disabilities in this population.…”

Section: Discussionmentioning

confidence: 95%

Sarcoscore: A Novel Approach for Assessing Sarcopenia and Functional Disability in Older Adults

Osuka

Kim

Kawai

et al. 2020

JCM

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Sarcopenia is associated with instrumental activities of daily living (IADL) and basic activities of daily living (BADL) disabilities. We developed an index for assessing sarcopenia degree (sarcoscore) and compared it to the Asian Working Group for Sarcopenia (AWGS) criteria. Principal component analyses of walking speed, handgrip strength, and skeletal muscle index were performed to develop a sarcoscore using 3088 Japanese population-based cross-sectional data. During the nine-year follow-up, 278 of 2571 and 88 of 2341 participants developed IADL and BADL disabilities, respectively. Adjusted Cox proportional hazards regression models showed that the sarcoscore criteria, defined as proportional to the sarcopenia prevalence diagnosed by the AWGS criteria, had higher hazard ratios (HRs) and 95% confidence interval (CI) for disability onset than the AWGS criteria (IADL disability: 2.19 (1.64–2.93) vs. 1.79 (1.32–2.43), BADL disability: 4.28 (2.63–6.96) vs. 3.22 (1.97–5.27)). The adjusted HRs for IADL and BADL disabilities were reduced by 4% and 8% per point increase in the sarcoscore, respectively. The sarcoscore assessed the degree of sarcopenia and had a satisfactory performance for predicting functional disabilities in older Japanese adults, suggesting its usefulness as a complementary composite marker for clinical diagnosis.

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“…In Abgrenzung zu anderen, eher lokalen neuromuskulären Erkrankungen ist Sarkopenie ein generalisierter Verlust an Muskelkraft, Muskelfunktion und Muskelmasse, der mit negativen gesundheitlichen Folgen wie Immobilität, Stürzen, Frakturen, Gebrechlichkeit und Mortalität einhergeht [4]. In Deutschland zeigten die Daten einer bevölkerungsbezogenen Studie in der Region Augsburg (Bayern) eine Prävalenz von ▪ 5,7 % in der Altersgruppe > 65 Jahre sowie ▪ 16,5 % (Frauen) und 8,6 % (Männer) in der Altersgruppe > 80 Jahre [5].…”

Section: Merkeunclassified

Die aktuelle Sarkopenie-Definition

Ferrari¹,

Drey²

2020

Dtsch Med Wochenschr

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Sarcopenia is characterized by a generalized loss of muscle function, strength and mass and is codable in Germany since 2018 in the ICD-10-GM (M62.50). For screening in primary care, it is possible to determine muscle function and strength by means of a sarcopenia questionnaire (SARC-F) as a self-filler with 5 questions of restrictions. With an increased score of 4 and higher, an examination of the musculature and a determination of the skeletal muscle mass index should be performed via dual energy X-ray absorption measurement (DXA) or bioelectric impedance analysis (BIA). If hand and/or leg strength is limited, the patient has probable sarcopenia and, according to the current revised version of the European consensus on sarcopenia, therapy can already be started and the cause clarified. A DXA or BIA examination confirms the diagnosis of sarcopenia by a lowered skeletal muscle index. A follow-up examination is recommended to differentiate between acute or chronic sarcopenia and to assess the progression of the disease. The severity of the disease is defined by additional examinations such as gait speed, timed up and go test (TUG) and/or short physical performance battery (SPPB). Patients with sarcopenia suffer from increasing immobility and disability and have an increased risk of falls, fractures and mortality. Frequently, co-morbidities should be clarified in all affected patients.

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Sarcopenia is associated with disability status—results from the KORA-Age study

Cited by 35 publications

References 56 publications

Morphometrics predicts overall survival in patients with multiple myeloma spine metastasis: A retrospective cohort study

Morphometrics predicts overall survival in patients with multiple myeloma spine metastasis: A retrospective cohort study

Sarcoscore: A Novel Approach for Assessing Sarcopenia and Functional Disability in Older Adults

Die aktuelle Sarkopenie-Definition

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