Sarcoplasmic lipase and non-specific esterase inhibition in myofibers of rats intoxicated with the organophosphate isofenphos

Calore, Edenilson Eduardo; Sesso, Antônio; Puga, F.R.; Cavaliere, Maria José; Calore, Nilda Maria Perez; Weg, Ruth B.

doi:10.1016/s0940-2993(99)80054-2

Cited by 14 publications

(11 citation statements)

References 18 publications

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“…Serum CPK level remains the best biomarker for detecting and monitoring skeletal muscle damage and diseases. Also authors [14,30] confirmed the elevation of serum CPK levels in acute OP poisoning, especially if the patient is severely poisoned, presumably due to muscle fiber necrosis. However, the main disadvantage of serum CPK as a biomarker for acute OP poisoning, its non-specificity.…”

Section: Discussionmentioning

confidence: 83%

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Correlation between Serum Creatine Phosphokinase and Severity of Acute Organophosphorus Poisoning: A Prospective Clinical Study (2012-2013

Hassan¹,

Madboly²

2013

IOSR-JESTFT

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Section: Discussionmentioning

confidence: 83%

“…Muscle fiber necrosis and consequently raised CPK levels occur in severely acute OP poisoned cases [30,31]. So, cheaper, easily quantifiable and more available biochemical markers in relation to OP poisoning like serum CPK can be used in predicting as well as assessing the prognosis of patients with OP poisoning [14].…”

Section: Discussionmentioning

confidence: 99%

Correlation between Serum Creatine Phosphokinase and Severity of Acute Organophosphorus Poisoning: A Prospective Clinical Study (2012-2013

Hassan¹,

Madboly²

2013

IOSR-JESTFT

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“…[14] A study conducted by Sharma et al . has shown that CPK was elevated in a fraction of their cases who had severe poisoning.…”

Section: Discussionmentioning

confidence: 99%

Serum creatine phosphokinase: A probable marker of severity in organophosphorus poisoning

Bhattacharyya¹,

Phaujdar²,

Sarkar³

et al. 2011

Toxicol Int

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Organophosphorus (OP), the commonest agent for poisoning in India due to its easy availability, acts by inhibiting acetylcholinesterase at muscarinic and nicotinic receptors. Erythrocyte cholinesterase (EchE) and plasma cholinesterase (PchE) are reduced in OP poisoning, but their estimation is costly and not regularly performed. There are emerging options for new cheaper biochemical markers in relation to OP poisoning. Serum level of creatine phosphokinase (CPK) is often found to be elevated in OP poisoning. This study was conducted to see if CPK may be used as an alternative of cholinesterase levels in blood to assess the severity of OP poisoning. This was a prospective and observational study. Sixty-three patients of OP poisoning without any prior treatment, presenting within 6 hours, were selected and their clinical severity was categorized according to Peradeniya organophosphorus poisoning (POP) scale. Level of serum CPK, blood EchE and pH were measured following admission, and total dose of atropine (mg) until the final clinical outcome (complete recovery or death) was calculated. Student's t-test and Pearson's correlation coefficient was used for the assessment of statistical significance. According to POP scale, clinical severity was mild (score 0–3) in 17 (27%), moderate (score 4–7) in 32 (50.8%) and severe (score 8–11) in 14 (22.2%) patients. Serum CPK, EchE level, blood pH and total atropine dose strongly correlated with clinical severity. Our study recommends serum CPK as an alternative marker.

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“…Brigth et al (1991) observed calcium ions next to the neuromuscular junctions in muscle "bers of mice intoxicated with the organophosphate sarin and suggested that accumulation of this ion plays a role in muscle "ber necrosis. Calore et al (1999) reported inhibition of sarcoplasmic esterase and sarcoplamic lipase activity in animals intoxicated with the organophosphate isofenphos. This inhibition occurred only roughly in parallel with the inhibition of plasma cholinesterase activity.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Early and Late Administration of Pralidoxime against Organophosphate Muscle Necrosis

Santos

Cavaliere

Puga

et al. 2002

Ecotoxicology and Environmental Safety

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Sarcoplasmic lipase and non-specific esterase inhibition in myofibers of rats intoxicated with the organophosphate isofenphos

Cited by 14 publications

References 18 publications

Correlation between Serum Creatine Phosphokinase and Severity of Acute Organophosphorus Poisoning: A Prospective Clinical Study (2012-2013

Correlation between Serum Creatine Phosphokinase and Severity of Acute Organophosphorus Poisoning: A Prospective Clinical Study (2012-2013

Serum creatine phosphokinase: A probable marker of severity in organophosphorus poisoning

Protective Effect of Early and Late Administration of Pralidoxime against Organophosphate Muscle Necrosis

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