Sarcoplasmic Reticulum Ca2+ Dysregulation in the Pathophysiology of Inherited Arrhythmia: An Update

Du, Yuxin; Demillard, Laurie J.; Ren, Jun

doi:10.1016/j.bcp.2022.115059

Cited by 9 publications

(3 citation statements)

References 158 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…, atrial septal defects), heart failure, and arrhythmia. 53 , 54 , 55 Sarcomeres are the basic contractile units of striated muscle fibres, comprising contractile, structural, and regulatory proteins; actin (thin filaments) and myosin (thick filaments) are the main proteins responsible for muscle contraction. The forces responsible for filament sliding arise from cross-bridges, in which myosin heads protrude from the myosin backbone to cyclically interact with actin filaments.…”

Section: As In Sarcomeric Genes Contributes To Cardiovascular Diseasesmentioning

confidence: 99%

Therapeutic potential of alternative splicing in cardiovascular diseases

Cao,

Wei,

Nie

et al. 2024

eBioMedicine

View full text Add to dashboard Cite

Section: As In Sarcomeric Genes Contributes To Cardiovascular Diseasesmentioning

confidence: 99%

Therapeutic potential of alternative splicing in cardiovascular diseases

Cao,

Wei,

Nie

et al. 2024

eBioMedicine

View full text Add to dashboard Cite

“…In addition to Na + and K + ions, Ca 2+ is another key ion in arrhythmogenesis. Inherited arrhythmias may also be induced by gene mutations of sarcoplasmic reticulum (SR) proteins regulating Ca 2+ homeostasis [16] .…”

Section: Genetic Findings Of Brugada Syndromementioning

confidence: 99%

Brugada syndrome: from genetics, diagnosis to clinical therapy

Huang,

Ren

2023

Cardiology Plus

Self Cite

View full text Add to dashboard Cite

Brugada syndrome is an inherited disease closely associated with genetic mutations, resulting in ventricular fibrillation and sudden cardiac death. To date, more than 40 genes have been identified to participate in the etiology of this devastating myocardial pathology, among which SCN5A is the predominant cause. Although considerable advances have been made in the molecular genetics of Brugada syndrome over the past decades, a comprehensive view of gene variants associated with Brugada syndrome pathogenicity and their pathophysiological mechanisms is still lacking. Recent studies have reanalyzed and reevaluated relevant genes and further elaborated genetic mechanisms underneath Brugada syndrome. Currently, gene-specific therapies based on culprit pathogenic genes are rapidly evolving, thus offering prospects for future research.

show abstract

“…La homeostasis del calcio regulada por el retículo sarcoplásmico se desarrolla dentro de los cardiomiocitos, involucrando varios reguladores como receptor de rianodina tipo 2 (RyR2), calsequestrina 2 (CASQ2), SR Ca ATPasa tipo 2 (SERCA2a) y fosfolamban (PLN), así como las interacciones con diversas estructurales (mitocondria, lisosomas, membrana plasmática), es decir, la presencia de cualquier defecto en el sistema regulador del calcio generara un incremento del riesgo de producción de arritmias (Du et al, 2022).…”

Section: Introductionunclassified

Ritmo Idioventricular: caso clínico

Espinoza,

Sumba,

Mesa

2024

rgn

View full text Add to dashboard Cite

El RIVA se considera la arritmia de mayor prevalencia durante la fase de resolución del infarto agudo de miocardio. la infraestimación del riesgo real sobre ciertas causas adyacentes podría condicionar el desarrollo de complicaciones, siendo determinante la identificación de cambios electrocardiográficas. Determinar los diferentes contextos clínicos que orientan hacia el ritmo idioventricular y su diferenciación de la taquicardia ventricular, así como de otras alteraciones análogas. Con base en criterios de inclusión y exclusión se ejecutó un análisis de caso clínico, junto al análisis de bibliografía de alto impacto. Paciente de 74 años de edad acude a evaluación cardiovascular posterior a IAM, hemodinámicamente estable; se realizó electrocardiograma encontrándose un RIVA más salvas de fibrilación auricular. En conclusión, el manejo especifico se reserva en casos de inestabilidad hemodinámica, asimismo se deberá hacer énfasis en la prevención y control de factores de riesgo cardiovascular.

show abstract

Sarcoplasmic Reticulum Ca2+ Dysregulation in the Pathophysiology of Inherited Arrhythmia: An Update

Cited by 9 publications

References 158 publications

Therapeutic potential of alternative splicing in cardiovascular diseases

Therapeutic potential of alternative splicing in cardiovascular diseases

Brugada syndrome: from genetics, diagnosis to clinical therapy

Ritmo Idioventricular: caso clínico

Contact Info

Product

Resources

About