SARS-CoV-2 E484K Mutation Narrative Review: Epidemiology, Immune Escape, Clinical Implications, and Future Considerations

Yang, Wanting; Huang, Wei-Chieh; Liao, Tsai‐Ling; Hsiao, Tzu‐Hung; Chuang, Han‐Ni; Liu, Po‐Yu

doi:10.2147/idr.s344099

Cited by 39 publications

(15 citation statements)

References 49 publications

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“…Intriguingly, the SNP E484A/K/Q is the most recurring mutation among all the variants after D614G. Further replacement of this site with Arg(R) or Asp (D) may increase the binding affinity and is expected to be observed in the new upcoming variants (Cherian et al, 2021; Yang et al, 2022). The other 3 SNPs (L452R/Q, S477N, T478K) introduce additional Nitrogen atom required for the formation of hydrogen bonds with ACE2 leading to stabilized interactions.…”

Section: Resultsmentioning

confidence: 99%

Insights into the microevolution of SARS-ACE2 Interactions: In-silico analysis of glycosylation and SNP pattern

Madasu

Maity

Ghosh

et al. 2022

Preprint

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The prefatory protein-glycan interaction and stabilizing protein-protein interaction of severe acute respiratory syndrome viruses with angiotensin-converting enzyme 2 play a significant role in complex formation thereby promoting endocytosis. The microevolution of SARS-CoV-2 over a period of time has a significant role in increasing the affinity of receptor-binding domain against angiotensin converting-enzyme 2. In the current study, we have corroborated the vitality of acquired SNPs over a period of time with increased affinity by using docking studies. The results indicate that the virus modulates the undesirable glycosylation sites by a series of substitution and deletion mutations. It uses bulky residues such as Tyr/Phe for dynamic arrest for quick stabilization of the complex, and Lys residues for stabilizing via hydrogen bond formation besides increasing the binding affinity to ease the cell entry.

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Section: Resultsmentioning

confidence: 99%

Insights into the microevolution of SARS-ACE2 Interactions: In-silico analysis of glycosylation and SNP pattern

Madasu

Maity

Ghosh

et al. 2022

Preprint

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“…This mutation reduces the neutralization potency of antibodies. [94] , [95] 3. N501Y Increasing the electrostatic interactions between S-protein and ACE2 by a strong hydrogen bond near the mutation site.…”

Section: Discussionmentioning

confidence: 99%

Omicron (B.1.1.529) - A new heavily mutated variant: Mapped location and probable properties of its mutations with an emphasis on S-glycoprotein

Chakraborty

Bhattacharya²,

Sharma³

et al. 2022

International Journal of Biological Macromolecules

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“…E484K mutations has occurred in multiple variants. It was initially discovered in South Africa variant and later in the Brazilian variant (24). The E484K mutation occurs in spike protein and initiating the viral entry process.…”

Section: E484kmentioning

confidence: 99%

SARS-COV-2 Notable Mutations and Variants: A Review Article

Farhud¹,

Mojahed²

2022

ijph

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SARS-COV-2 (COVID-19) the virus that caused an epidemic of sever acute respiratory syndrome is what the world has been dealing with since Dec 2019. As the pandemic continues different variants that emerge during mutations have become the latest concern, with notable examples detected in South Africa, Brazil, and UK. Variants are complicated and each one is a collection of several mutations, all of which have the potential to change the virus in unexpected ways. Studying variants is imperative as they can lead the epidemic to the increase of population immunity. In the present study, we reviewed key mutations and concerning variants according to the WHO tracking Sars-Cov-2 program. Databases were searched through Feb to Mar 2022. Overall, 477 studies were extracted from databases, among them 165 studies included mutations, 239 included COVID-19 variants and 43 included both mutations and variants. At the final step of data screening 24 studies associated to mutations, 31 studies with the highlighted information on COVID-19 variants and 31 studies related to both mutations and variants were extracted for this review article. In conclusion, analyses of the genomic sequence of SARS-CoV-2 indicate that structural proteins are key molecules in the assembly of virus while NSPs can have different biochemical properties and possibly cellular functions.

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SARS-CoV-2 E484K Mutation Narrative Review: Epidemiology, Immune Escape, Clinical Implications, and Future Considerations

Cited by 39 publications

References 49 publications

Insights into the microevolution of SARS-ACE2 Interactions: In-silico analysis of glycosylation and SNP pattern

Insights into the microevolution of SARS-ACE2 Interactions: In-silico analysis of glycosylation and SNP pattern

Omicron (B.1.1.529) - A new heavily mutated variant: Mapped location and probable properties of its mutations with an emphasis on S-glycoprotein

SARS-COV-2 Notable Mutations and Variants: A Review Article

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