SARS-CoV-2 Sequelae and Postdischarge Health Care Visits Over 5 Months Follow-up Among Children Hospitalized for COVID-19 or MIS-C

Doshi, Jalpa A.; Sheils, Natalie E.; Buresh, John; Quinicot, Elijah; Islam, Nazmul; Chen, Yong; Asch, David A.; Werner, Rachel M.; Swami, Sanjeev

doi:10.1097/inf.0000000000003692

Cited by 4 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Twenty two studies (40%) were assessed to have high risk of bias [ 22 , 23 , 25 , 27 , 30 – 32 , 34 , 39 – 45 , 48 – 52 , 58 , 66 ], eight (15%) moderate [ 24 , 26 , 37 , 53 , 57 , 62 , 65 , 67 ] and 25 (45%) low risk of bias [ 10 – 12 , 19 , 20 , 28 , 29 , 33 , 35 , 36 , 38 , 46 , 47 , 54 – 56 , 59 – 61 , 63 , 64 , 68 – 72 ]. Two hundred and nineteen symptoms were reported across the 55 studies.…”

Section: Resultsmentioning

confidence: 99%

Persistent symptoms are associated with long term effects of COVID-19 among children and young people: Results from a systematic review and meta-analysis of controlled studies

Behnood,

Newlands,

O’Mahoney

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

Background Research on the long-term impact on COVID-19 in children and young people (CYP) has been published at pace. We aimed to update and refine an earlier systematic review and meta-analysis to assess the current evidence for Post-COVID-19 Condition in CYP. Methods Studies from the previous systematic review were combined with studies from a systematic search from July 2021 to November 2022 (registration PROSPERO CRD42021233153). Eligible studies included CYP aged ≤19 years with confirmed or probable SARS-CoV-2 infection and symptoms persisting at least 12 weeks. Findings 55 studies (n = 1,139,299 participants) were included. Over two-hundred symptoms were associated with Post COVID-19 Condition. Gastrointestinal problems, headaches, cough and fever were among the most prevalent symptoms with rates of 50.2%, 35.6%, 34.7% and 25.8% respectively. Twenty-one symptoms from 11 studies were suitable for meta-analysis. There were significantly higher pooled estimates of proportions of symptoms for altered / loss of smell or taste, dyspnoea, fatigue, and myalgia in CYP with confirmed SARS-CoV-2 infection. Heterogeneity was high suggesting substantial variation amongst the included studies. Conclusions Many CYP continue to experience symptoms after SARS-CoV-2 infection. Efforts to aid early identification and intervention of those most in need is warranted and the consequences of COVID-19 for CYP call for long-term follow-up.

show abstract

Section: Resultsmentioning

confidence: 99%

Persistent symptoms are associated with long term effects of COVID-19 among children and young people: Results from a systematic review and meta-analysis of controlled studies

Behnood,

Newlands,

O’Mahoney

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

show abstract

Prevalence of symptoms of post‐COVID‐19 condition (long COVID) in children hospitalized with COVID‐19: A systematic review of observational studies

Silva,

Benites,

Castro

et al. 2024

Pediatric Pulmonology

View full text Add to dashboard Cite

This systematic review aimed to investigate the prevalence of symptoms of post‐COVID‐19 condition (long COVID), in children hospitalized with COVID‐19. We searched PUBMED and EMBASE on 15 March, 2023, using search strategy: “long COVID” OR “post‐COVID‐19” OR “postacute COVID‐19” OR “long‐term COVID” OR “COVID‐19 sequelae” OR “persistent COVID‐19” OR “chronic COVID‐19”. We included observational studies (case‐control, cross‐sectional, cohort, or case series) that investigated symptoms of post‐COVID‐19 condition (long COVID) in children (<18 years) admitted with COVID‐19. We used the WHO case definition of post‐COVID‐19 condition. Long COVID was defined as persistence of otherwise unexplained symptoms for at least three months after SARS‐CoV‐2 infection. We used the command “metaprop” to perform random‐effects meta‐analysis. Eleven studies involving 2279 patients were included. In the period between ≥3 months and <12 months after acute COVID‐19, the most frequent symptom was exercise intolerance with a pooled prevalence of 29% (95% CI: 7%–57%, I2 = 95%), followed by nonspecific respiratory symptoms (12%, 95% CI: 0%–48%, I2 = 0%), psychological disorders (10%, 95% CI: 1%–25%, I2 = 97%), and nonspecific gastrointestinal symptoms (10%, 95% CI: 0%–37%, I2 = 99%). In the period ≥12 months after the initial infection, the pooled prevalence of post COVID symptoms was lower, with 6% (95% CI: 2%–10%, I2 = 83%) for exercise intolerance and 3% (95% CI: 0%–8%, I2 = 89%) for fatigue. In conclusion, symptoms of post‐COVID condition (long COVID) in hospitalized children affect multiple organ systems, with higher prevalence in the period up to 12 months after the acute phase of COVID‐19.

show abstract

Clinical insights: Resolving the specter of cardiac sequelae in multisystem inflammatory syndrome in children (MIS-C) – A 24-month follow-up case series

Capuruco,

Albuquerque,

Rosa

et al. 2024

Progress in Pediatric Cardiology

View full text Add to dashboard Cite

SARS-CoV-2 Sequelae and Postdischarge Health Care Visits Over 5 Months Follow-up Among Children Hospitalized for COVID-19 or MIS-C

Cited by 4 publications

References 15 publications

Persistent symptoms are associated with long term effects of COVID-19 among children and young people: Results from a systematic review and meta-analysis of controlled studies

Persistent symptoms are associated with long term effects of COVID-19 among children and young people: Results from a systematic review and meta-analysis of controlled studies

Prevalence of symptoms of post‐COVID‐19 condition (long COVID) in children hospitalized with COVID‐19: A systematic review of observational studies

Clinical insights: Resolving the specter of cardiac sequelae in multisystem inflammatory syndrome in children (MIS-C) – A 24-month follow-up case series

Contact Info

Product

Resources

About