2024
DOI: 10.1083/jcb.202404131
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SARS-CoV-2 specific adaptations in N protein inhibit NF-κB activation and alter pathogenesis

Xiao Guo,
Shimin Yang,
Zeng Cai
et al.

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and severe acute respiratory syndrome coronavirus (SARS-CoV) exhibit differences in their inflammatory responses and pulmonary damage, yet the specific mechanisms remain unclear. Here, we discovered that the SARS-CoV-2 nucleocapsid (N) protein inhibits the activation of the nuclear factor-κB (NF-κB) pathway and downstream signal transduction by impeding the assembly of the transforming growth factor β-activated kinase1 (TAK1)–TAK1 binding protein 2/3… Show more

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