SARS-CoV-2 spike proteins react with Au and Si, are electrically conductive and denature at 3 × 10<sup>8</sup> V m<sup>−1</sup>: a surface bonding and a single-protein circuit study

Dief, Essam M.; Darwish, Nadim

doi:10.1039/d2sc06492h

“…3a and b). 53,54 In addition to the data concerning most probable molecular conductance, the 1D and 2D data plots also contain information concerning the geometry of the molecule within the junction. It is important to highlight that the terms 'plateau length' usually refers to the difference in electrode separation from junction formation to junction breakdown, while 'tip displacement' is measured as the distance from the cleavage of the last Au-Au atomic point to the breakdown of the junction.…”

Section: Formation Of Single-molecule Junctionsmentioning

confidence: 99%

Methods for the analysis, interpretation, and prediction of single-molecule junction conductance behaviour

Gorenskaia,

Low

2024

Chem. Sci.

1

0

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Electrochemically Gated Frustrated Lewis Pair Chemistry in Electric Double Layer

Guo,

Wan,

Jiang

et al. 2024

Angewandte Chemie

0

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The recent discovery of frustrated Lewis pairs (FLPs) during the activation of small molecules has inspired extensive research across the full span of chemical science. Owing to the nature of weak interactions, it is experimentally challenging to directly observe and modulate FLP at the molecular scale. Here we design a boron cluster anion building block (B10H82‐) and organic amine cations ([NR4]+, R= ‐CH3, ‐C2H5) as the FLP to prove the feasibility of controlling their interaction in the electric double layer (EDL) via an electrochemical strategy. In situ single‐molecule electrical measurements and Raman monitoring of B10H82‐–[NR4]+ FLP formed at the positively charged Au(111) electrode surface, in contrast to the free‐standing B10H82‐ near or below the potential of zero charge (PZC). Furthermore, this FLP chemistry leads to a shift in the local density of states of boron clusters towards the EF for enhancing electron transport, providing a new prototype of a reversible single‐cluster switch that digitally switches upon controlling FLP chemistry in the electric double layer.

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Electrochemically Gated Frustrated Lewis Pair Chemistry in Electric Double Layer

Guo,

Wan,

Jiang

et al. 2024

Angew Chem Int Ed

0

View full text Add to dashboard Cite

The recent discovery of frustrated Lewis pairs (FLPs) during the activation of small molecules has inspired extensive research across the full span of chemical science. Owing to the nature of weak interactions, it is experimentally challenging to directly observe and modulate FLP at the molecular scale. Here we design a boron cluster anion building block (B10H82‐) and organic amine cations ([NR4]+, R= ‐CH3, ‐C2H5) as the FLP to prove the feasibility of controlling their interaction in the electric double layer (EDL) via an electrochemical strategy. In situ single‐molecule electrical measurements and Raman monitoring of B10H82‐–[NR4]+ FLP formed at the positively charged Au(111) electrode surface, in contrast to the free‐standing B10H82‐ near or below the potential of zero charge (PZC). Furthermore, this FLP chemistry leads to a shift in the local density of states of boron clusters towards the EF for enhancing electron transport, providing a new prototype of a reversible single‐cluster switch that digitally switches upon controlling FLP chemistry in the electric double layer.

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SARS-CoV-2 spike proteins react with Au and Si, are electrically conductive and denature at 3 × 10⁸ V m⁻¹: a surface bonding and a single-protein circuit study

Abstract: Developing means to characterise SARS-CoV-2 and its new variants is critical for future outbreaks. SARS-CoV-2 spike proteins have peripheral disulfide bonds (S–S), which are common in all spike proteins of...

Cited by 7 publications

References 82 publications

Methods for the analysis, interpretation, and prediction of single-molecule junction conductance behaviour

Methods for the analysis, interpretation, and prediction of single-molecule junction conductance behaviour

Electrochemically Gated Frustrated Lewis Pair Chemistry in Electric Double Layer

Electrochemically Gated Frustrated Lewis Pair Chemistry in Electric Double Layer

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Product

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SARS-CoV-2 spike proteins react with Au and Si, are electrically conductive and denature at 3 × 108 V m−1: a surface bonding and a single-protein circuit study

Abstract: Developing means to characterise SARS-CoV-2 and its new variants is critical for future outbreaks. SARS-CoV-2 spike proteins have peripheral disulfide bonds (S–S), which are common in all spike proteins of...

Cited by 7 publications

References 82 publications

Methods for the analysis, interpretation, and prediction of single-molecule junction conductance behaviour

Methods for the analysis, interpretation, and prediction of single-molecule junction conductance behaviour

Electrochemically Gated Frustrated Lewis Pair Chemistry in Electric Double Layer

Electrochemically Gated Frustrated Lewis Pair Chemistry in Electric Double Layer

Contact Info

Product

Resources

About

SARS-CoV-2 spike proteins react with Au and Si, are electrically conductive and denature at 3 × 10⁸ V m⁻¹: a surface bonding and a single-protein circuit study