SAT0296 Relationship between disease activity index scores and subjective assessments in early systemic lupus erythematosus

Abstract

As compared to the incidence in general French population, invasive PI was 26 times more frequent in SLE patients. PI occurred at a younger age (43.5+14.9 versus 65.3+18.7 years, p=0.009) and was more severe, with a higher frequency of invasive infection (p<0.001) and higher need for ICU admission (p=0.015) in SLE as compared to non SLE patients. Of note, unusual PI sites, including pneumococcal endocarditis (n=1), arthritis (n=1) and peritonitis (n=1) were observed in SLE patients only. Risk factors associated with PI in SLE patients were a serum gammaglobulin level <5g/L (p=0.003) and a past history of lupus nephritis (p=0.047), only. Steroids (p<0.001) and immunosuppressive drugs (p=0.027) were associated with infection severity. Conclusions: Pneumococcal infections occur at a younger age, are more frequent and severe in SLE patients. Hypogammaglobulinemia and lupus nephritis increased the risk for PI, whereas steroids and immunosuppressive drugs were associated with infection severity only. Our study shows that SLE patients have an increased risk for invasive PI and points to the need for vaccination against streptococcus pneumoniae in SLE.

Addition of constitutional symptoms to the SLEDAI-2K improves overall disease activity assessment: A pilot study

“…Consistent with previous studies, both SLED-R and SLED-O demonstrated weak correlations with PtGA compared to the more robust correlations between SLED-R or SLED-O and PGA. 53,54 Also consistent with previous studies, PtGA scores were more frequently greater than PGA scores. 30,39 Surprisingly, the SLED-R and SLED-O correlations with PtGA were not significantly different.…”