Satisfaction and Impact on Quality of Life of Clinical and Instrumental Surveillance and Prophylactic Surgery in BRCA-mutation Carriers

Attitudes towards risk‐reducing early salpingectomy with delayed oophorectomy for ovarian cancer prevention: a cohort study

“…Our data show 50.7% (346/683) RRSO uptake, which is consistent with literature reports of 12–78% 14,24,27,36,41–68 . Uptake was higher among older women, women who completed childbearing, those who had BC themselves, and those having undergone RRM.…”

Management of patients with BRCA mutation from the point of view of a breast surgeon

“…PBSO renders an anticipated early menopause which has unfortunate physical and psychological consequences ([ 39 , 40 ]). Premenopausal women undergoing PBSO experience hot flashes and night sweats (40%), dyspareunia (17%), and decreased libido (22%) [ 41 ].…”

“…A study using anonymous questionnaires reveals that women who follow a surveillance program show a good level of satisfaction because it lowers the concerns of cancer risk. Satisfaction is also high in women undergoing risk reducing procedures mainly for the same reason [ 40 ]. The risk reduction benefit of RRM compared to surveillance has not been addressed in randomized studies.…”

Surgical strategy in BRCA-associated breast cancer. Clinical case

“…Пациентам с мутациями в гене BRCA1 рекомендовано выполнение ПСОЭ в возрасте до 40 лет, после выполнения репродуктивной функции, тогда как для носителей мутаций в гене BRCA2 рекомендуемый возраст выполнения ПСОЭ выше на 10 лет. Кроме того, в данном исследовании проведен анализ качества жизни больных после выполнения ПСОЭ и сделан вывод о том, что двусторонняя ПСОЭ может снизить качество жизни женщин изза симптомов ранней менопаузы даже на фоне заместительной гормонотерапии [15].…”