Saturation Prostate Needle Biopsy and Prostate Cancer Detection at Initial and Repeat Evaluation

Pepe, Pietro; Aragona, Francesco

doi:10.1016/j.urology.2007.07.068

Cited by 108 publications

(70 citation statements)

References 21 publications

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“…Other large transrectal saturation biopsy series report detection rates of 25-40% in men with earlier negative biopsies. 11,[18][19][20] However, two-thirds to three-quarters of the cancers identified in these studies were Gleason score p6, [18][19][20] supporting the assertion that repeat TRUS biopsy is likely to identify lower grade disease.…”

Section: Discussionmentioning

confidence: 61%

“…8,9 Increasing the number of transrectal cores at initial biopsy does not appear to significantly improve yield. 10,11 Eichler et al 8 pooled data from 68 studies and found a significant improvement in cancer detection moving from the standard sextant scheme to a 12-core approach. However, there was no benefit to further increasing the number of cores taken.…”

Section: Discussionmentioning

confidence: 99%

“…For each biopsy core, the template coordinate and the offset from base were recorded. Biopsy regions included posterior prostate (3,4,12,13,21,22), posterior lateral (2,5,11,14,20,23), anterior lateral (1,6,9,10,15,16), anterior apex (19,24), and TZ (7,8,17,18) After completion of all sampling, patients underwent cystoscopic evaluation.…”

Section: Methodsmentioning

confidence: 99%

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Performance of transperineal template-guided mapping biopsy in detecting prostate cancer in the initial and repeat biopsy setting

Taira

Merrick

Galbreath

et al. 2009

Prostate Cancer Prostatic Dis

262

171

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Transrectal ultrasound (TRUS) biopsy can miss 20-30% of clinically significant cancers. We evaluate an alternative approach-transperineal template-guided mapping biopsy (TTMB) in the initial and repeat biopsy setting. From January 2005 through September 2008, 373 consecutive men underwent TTMB (294 men with X1 prior negative biopsy and 79 men as the initial biopsy). The location of each positive biopsy core, number of positive cores, and percent involvement of each core was recorded. Cancer detection rate for the initial biopsy was 75.9%. For men with 1, 2, and X3 prior negative biopsies detection rates were 55.5%, 41.7%, and 34.4%, respectively. In all, 55.5% of the cancers identified were Gleason X7. The majority of the cancers were multifocal. There was no significant change in the number of positive cores or Gleason score as the number of prior biopsies increased. The anterior and apical aspects of the prostate were among the most common cancer locations. TTMB provides a high rate of cancer detection as initial and repeat biopsy. TTMB was particularly effective at diagnosing anterior and apical cancer. TTMB may have particular application for men considering active surveillance, with prior negative TRUS biopsies, and those considering subtotal gland or other minimally invasive treatments.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Performance of transperineal template-guided mapping biopsy in detecting prostate cancer in the initial and repeat biopsy setting

Taira

Merrick

Galbreath

et al. 2009

Prostate Cancer Prostatic Dis

262

171

View full text Add to dashboard Cite

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“…In our experience, 9 PCa detection rate of 22.6% in 75 patients submitted to SPBx after an initial negative extended biopsy was found.…”

Section: Discussionmentioning

confidence: 58%

“…Until now, an extended transrectal ultrasound-guided biopsy scheme with an increased number of cores on the peripheral portion and on the lateral margins of the gland is the only suitable method to improve the detection rate of PCa; 7 however, the SPBx (that is, X24 cores) does not improve cancer detection rate in comparison with 12 or 18 cores biopsy as an initial prostate biopsy strategy. 8,9 Some parameters (time elapsed from the previous biopsy, previous high-grade prostatic intraepithelial neoplasia or atypical small acinar proliferation) have been proposed to predict positive repeat biopsy for cancer, 10,11 …”

Section: Discussionmentioning

confidence: 99%

Prostate cancer detection by TURP after repeated negative saturation biopsy in patients with persistent suspicion of cancer: a case–control study on 75 consecutive patients

Pepe

Fraggetta

Galia

et al. 2009

Prostate Cancer Prostatic Dis

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To evaluate prostate cancer (PCa) detection after repeated negative saturation biopsy, 75 patients, aged 53-78 years, underwent transurethral resection of prostate (TURP) because of persistent suspicion of cancer; median PSA was 11.8 ng ml À1 and 58 men complained lower urinary tract symptoms (LUTS). In 12 (16%) and 3 (4%) men a T1a and T1b PCa was found with median PSA and Gleason score equal to 14.2 vs 23.6 ng ml À1 and 5.6 vs 7 ng ml À1 . In case of persistent suspicion of PCa after repeated negative saturation biopsy, TURP may be proposed, aside from the coexistence of LUTS, to rule out a PCa, in younger patients with high PSA values (X20 ng ml À1 ).

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Imaging

Richenberg

2014

Prostate Cancer

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Saturation Prostate Needle Biopsy and Prostate Cancer Detection at Initial and Repeat Evaluation

Cited by 108 publications

References 21 publications

Performance of transperineal template-guided mapping biopsy in detecting prostate cancer in the initial and repeat biopsy setting

Performance of transperineal template-guided mapping biopsy in detecting prostate cancer in the initial and repeat biopsy setting

Prostate cancer detection by TURP after repeated negative saturation biopsy in patients with persistent suspicion of cancer: a case–control study on 75 consecutive patients

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