Sauchinone, a lignan from Saururus chinensis, reduces tumor necrosis factor-α production through the inhibition of c-raf/MEK1/2/ERK 1/2 pathway activation

Sauchinone suppresses lipopolysaccharide-induced inflammatory responses through Akt signaling in BV2 cells

“…Lee et al suggested that sauchinone's action might be mediated by JNK activation in BV2 cells treated with dsRNA. This result is inconsistent with our result and with a previous study [17] in which JNK activation was not found to be involved in the effect of sauchinone on LPS-induced inflammatory response. However, LPS binds to toll-like receptor 4 (TLR4) in plasma membrane of immune cells, but dsRNA binds to TLR3 in endosomal membrane [21].…”

“…These results demonstrate that the activation of p38, JNK and ERK1/2 is not involved in the inhibitory effect of sauchinone on the inflammatory response in BV2 cells. This finding is partially consistent with a previous study [17]. The previous study showed that sauchinone did not inhibit the activation of p38 and JNK in Raw264.7 cells treated with LPS, whereas it reduced LPS-stimulated ERK1/2 activation [17].…”

“…This finding is partially consistent with a previous study [17]. The previous study showed that sauchinone did not inhibit the activation of p38 and JNK in Raw264.7 cells treated with LPS, whereas it reduced LPS-stimulated ERK1/2 activation [17]. Therefore, it is unlikely that sauchinone uses p38 and JNK signaling pathways to alleviate inflammatory responses in both macrophages and microglia.…”

“…Sauchinone is a polyphenolic compound found in plants and belongs to the lignan family [13] which has been reported to have hepatoprotective, anti-inflammatory and antioxidant activities in a few types of cells [14][15][16][17]. For example, sauchinone attenuated the damage of rat primary hepatocytes induced by CCl 4 treatment [15].…”

“…It has also been shown to inhibit the production of inflammatory factors such as TNF-α, COX-2 and NO in Raw 264.7 cells [16]. In addition, sauchinone was reported to modulate the expression of inflammatory factors via c-Raf/MEK/ERK1/2 MAP kinase signaling pathway [17]. However, there are few studies on the effect of sauchinone on microglia activation related to neurodegenerative disorders.…”