Saudi Experts Consensus on Diagnosis and Management of Pediatric Functional Constipation

Abstract

Although functional gastrointestinal disorders (FGIDs) are very common in pediatric patients, there is a scarcity of published epidemiologic data, characteristics, and management patterns from Saudi Arabia, which is the 2nd largest Arabic country in terms of area and the 6th largest Arabic country in terms of population, with 10% of its population aged <5 years. Functional constipation (FC) is an FGID that has shown a rising prevalence among Saudi infants and children in the last few years, which urges us to update our clinical practices. Nine pediatric consultants attended two advisory board meetings to discuss and address current challenges, provide solutions, and reach a Saudi national consensus for the management of pediatric constipation. The pediatric consultants agreed that pediatricians should pay attention to any alarming signs (red flags) found during history taking or physical examinations. They also agreed that the Rome IV criteria are the gold standard for the diagnosis of pediatric FC. Different therapeutic options are available for pediatric patients with FC. Dietary treatment is recommended for infants with constipation for up to six months of age. When non-pharmacological interventions fail to improve FC symptoms, pharmacological treatment with laxatives is indicated. First, the treatment is aimed at disimpaction to remove fecal masses. This is achieved by administering a high dose of oral polyethylene glycol (PEG) or lactulose for a few days. Subsequently, maintenance therapy with PEG should be initiated to prevent the re-accumulation of feces. In addition to PEG, several other options may be used, such as Mg-rich formulas or stimulant laxatives. However, rectal enemas and suppositories are usually reserved for cases that require acute pain relief. In contrast, infant formulas that contain prebiotics or probiotics have not been shown to be effective in infant constipation, while the use of partially hydrolyzed formula is inconclusive. These clinical practice recommendations are intended to be adopted by pediatricians and primary care physicians across Saudi Arabia.

Clinical profile of functional constipation in Saudi children

“… 6 The lack of local data in the Saudi expert consensus on the diagnosis and management of FC reflects the need for further research. 7 The objective of this study was to describe the clinical profile of FC in a cohort of Saudi children, a step toward improving the diagnosis and management of FC in this population.…”

Parents’ Knowledge, Attitude, and Practice Related to Childhood Constipation in Makkah, Saudi Arabia

“…Fecal incontinence, frequent abdominal pain, bleeding of the rectum, enuresis, and urinary retention and infection are all well-recognized complications of FC in children [ 6 ]. Fecal occlusion, intestinal/ileus blockage, toxic megacolon, and bowel perforation are the more catastrophic potential effects of FC [ 7 ].…”

Prevalence of functional gastrointestinal disorders in Saudi infants and toddlers: A cross-sectional multicenter study

“…[ 9 ] A recent national Saudi Arabian consensus for practical considerations and clinical implications of pediatric FGIDs, including functional constipation, was published. [ 10 ] Middle East consensus statement on the management of FGIDs in infants has also been published by medical experts. [ 11 ]…”