Saudi Moumouvirus, the First Group B Mimivirus Isolated from Asia

Bajrai, Leena Hussein; Assis, Felipe Lopes de; Azhar, Esam I.; Jardot, Priscilla; Robert, Caroline; Abrahão, Jônatas Santos; Raoult, Didier; Scola, Bernard La

doi:10.3389/fmicb.2016.02029

Cited by 9 publications

(3 citation statements)

References 33 publications

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“…Viruses of the family Mimiviridae had been isolated and characterized with increasing fre- quency recently in Asian countries such as Japan, India, and Saudi Arabia [1][2][3]. However, at the time of writing, there were no reports of giant amoebal viruses detected in South East Asia.…”

Section: Introductionmentioning

confidence: 99%

Isolation and Quantification of Mimivirus-Like and Marseillevirus-Like Viruses from Soil Samples in An Aboriginal (Orang asli) Village in Peninsular Malaysia

et al. 2018

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Background: The giant amoebal viruses of Mimivirus and Marseillevirus are large DNA viruses and have been documented in water, soil, and sewage samples. The trend of discovering these giant amoebal viruses has been increasing throughout Asia with Japan, India, and Saudi Arabia being the latest countries to document the presence of these viruses. To date, there have been no reports of large amoebal viruses being isolated in South East Asia. Objective: In this study, we aim to discover these viruses from soil samples in an aboriginal village (Serendah village) in Peninsular Malaysia. Method and Results: We successfully detected and isolated both Mimivirus-like and Marseillevirus-like viruses using Acanthamoeba castellanii. Phylogeny analysis identified them as Mimivirus and Marseillevirus, respectively. Conclusion: The ubiquitous nature of both Mimivirus and Marseillevirus is further confirmed in our study as they are detected in higher quantity in soil that is near to water vicinities in an aboriginal village in Peninsular Malaysia. However, this study is limited by our inability to investigate the impact of Mimivirus and Marseillevirus on the aboriginal villagers. More studies on the potential impact of these viruses on human health, especially on the aborigines, are warranted.

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Section: Introductionmentioning

confidence: 99%

Isolation and Quantification of Mimivirus-Like and Marseillevirus-Like Viruses from Soil Samples in An Aboriginal (Orang asli) Village in Peninsular Malaysia

et al. 2018

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“…Many viruses within the family Mimiviridae present fibrils on the surface of the capsid (11,22,94,98). In APMV, fibrils play a role in particle attachment on the amoeba's surfaces (99).…”

Section: Replication Cyclementioning

confidence: 99%

Amoebae: Hiding in Plain Sight: Unappreciated Hosts for the Very Large Viruses

et al. 2022

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For decades, viruses have been isolated primarily from humans and other organisms. Interestingly, one of the most complex sides of the virosphere was discovered using free-living amoebae as hosts. The discovery of giant viruses in the early twenty-first century opened a new chapter in the field of virology. Giant viruses are included in the phylum Nucleocytoviricota and harbor large and complex DNA genomes (up to 2.7 Mb) encoding genes never before seen in the virosphere and presenting gigantic particles (up to 1.5 μm). Different amoebae have been used to isolate and characterize a plethora of new viruses with exciting details about novel viral biology. Through distinct isolation techniques and metagenomics, the diversity and complexity of giant viruses have astonished the scientific community. Here, we discuss the latest findings on amoeba viruses and how using these single-celled organisms as hosts has revealed entities that have remained hidden in plain sight for ages. Expected final online publication date for the Annual Review of Virology, Volume 9 is September 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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“…Since the serendipitous discovery of Acanthamoeba polyphaga mimivirus (APMV) in 2003, dozens of studies have been conducted to describe how widespread and diverse this new viral family is La Scola et al (2003 , 2010 ), Raoult et al (2004) , Arslan et al (2011) , Colson et al (2011a , b ), Legendre et al (2012) , Boughalmi et al (2013b , c ), Saadi et al (2013a) , Yoosuf et al (2014a , b ). Concomitantly, researchers have been working on the biology and molecular characterization of other mimivirus relatives isolated from several human and environmental samples, the latter of which include cooling water tower, freshwater, saltwater, soil, leech, oyster, and other sources collected in many countries in Oceania, Europe, Asia, Africa, and South America ( La Scola et al, 2008 ; Fischer et al, 2010 ; Arslan et al, 2011 ; Yoosuf et al, 2012 ; Boughalmi et al, 2013a , b , c ; Pagnier et al, 2013 ; Saadi et al, 2013a , b ; Campos et al, 2014 ; Bajrai et al, 2016 ; Takemura et al, 2016 ). During those studies, notable sets of genes seemingly encoded by the genome of these new viruses were observed.…”

Section: Introductionmentioning

confidence: 99%

Genome Characterization of the First Mimiviruses of Lineage C Isolated in Brazil

et al. 2017

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The family Mimiviridae, comprised by giant DNA viruses, has been increasingly studied since the isolation of the Acanthamoeba polyphaga mimivirus (APMV), in 2003. In this work, we describe the genome analysis of two new mimiviruses, each isolated from a distinct Brazilian environment. Furthermore, for the first time, we are reporting the genomic characterization of mimiviruses of group C in Brazil (Br-mimiC), where a predominance of mimiviruses from group A has been previously reported. The genomes of the Br-mimiC isolates Mimivirus gilmour (MVGM) and Mimivirus golden (MVGD) are composed of double-stranded DNA molecules of ∼1.2 Mb, each encoding more than 1,100 open reading frames. Genome functional annotations highlighted the presence of mimivirus group C hallmark genes, such as the set of seven aminoacyl-tRNA synthetases. However, the set of tRNA encoded by the Br-mimiC was distinct from those of other group C mimiviruses. Differences could also be observed in a genome synteny analysis, which demonstrated the presence of inversions and loci translocations at both extremities of Br-mimiC genomes. Both phylogenetic and phyletic analyses corroborate previous results, undoubtedly grouping the new Brazilian isolates into mimivirus group C. Finally, an updated pan-genome analysis of genus Mimivirus was performed including all new genomes available until the present moment. This last analysis showed a slight increase in the number of clusters of orthologous groups of proteins among mimiviruses of group A, with a larger increase after addition of sequences from mimiviruses of groups B and C, as well as a plateau tendency after the inclusion of the last four mimiviruses of group C, including the Br-mimiC isolates. Future prospective studies will help us to understand the genetic diversity among mimiviruses.

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Saudi Moumouvirus, the First Group B Mimivirus Isolated from Asia

Cited by 9 publications

References 33 publications

Isolation and Quantification of Mimivirus-Like and Marseillevirus-Like Viruses from Soil Samples in An Aboriginal <b><i>(</i></b>Orang asli<b><i>)</i></b> Village in Peninsular Malaysia

Isolation and Quantification of Mimivirus-Like and Marseillevirus-Like Viruses from Soil Samples in An Aboriginal <b><i>(</i></b>Orang asli<b><i>)</i></b> Village in Peninsular Malaysia

Amoebae: Hiding in Plain Sight: Unappreciated Hosts for the Very Large Viruses

Genome Characterization of the First Mimiviruses of Lineage C Isolated in Brazil

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