Phytoplankton are the main primary producers in aquatic ecosystems. Their biomass production and CO 2 sequestration equals that of all terrestrial plants taken together. Phytoplankton productivity is controlled by a number of environmental factors, many of which currently undergo substantial changes due to anthropogenic global climate change. Most of these factors interact either additively or synergistically. Light availability is an absolute requirement for photosynthesis, but excessive visible and UV radiation impair productivity. Increasing temperatures enhance stratification and decrease the depth of the upper mixing layer exposing the cells to higher solar radiation and reduce nutrient upward transport from upwelling deeper water. At the same time, stratospheric ozone depletion exposes phytoplankton to higher solar UV-B radiation especially in polar and mid-latitudes. Terrestrial runoff carrying sediments and dissolved organic matter into coastal waters leads to eutrophication while reducing UV penetration. All these environmental forcings are known to affect physiological and ecological processes. Ocean acidification due to increased atmospheric CO 2 concentrations changes the seawater chemistry; it reduces calcification in phytoplankton, macroalgae and many zoological taxa. Ocean warming results in changing species composition and favors blooms of toxic prokaryotic and eukaryotic phytoplankton. Increasing pollution from crude oil spills, persistent organic pollutants, heavy metal as well as industrial and household wastewaters affect phytoplankton which is augmented by solar UV radiation. Extensive analyses of the impacts of multiple stressors are scarce. Here, we review reported findings on the impacts of anthropogenic stressors on phytoplankton with an emphasis on their interactive effects and make an effort to provide a prospect for future studies.