Scabies and mortality

Lynar, Sarah; Currie, Bart J.; Baird, Robert W.

doi:10.1016/s1473-3099(17)30636-9

Cited by 50 publications

(27 citation statements)

References 4 publications

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“…Scabies is often associated with secondary, opportunistic bacterial infections, a major concern in children in hyperendemic situations [ 2 , 5 ]. Here, scabies poses a high risk of potentially life-threatening Staphylococcus aureus bacteraemia and severe post-streptococcal sequelae [ 6 , 7 ], including rheumatic fever, heart disease and/or glomerulonephritis, representing a substantial mortality burden [ 8 ]. In spite of this knowledge, current epidemiological data underrepresent the actual scabies burden [ 9 ] due to an absence of accurate diagnostic tools and serious gaps in disease surveillance.…”

Section: Introductionmentioning

confidence: 99%

High-quality nuclear genome for Sarcoptes scabiei—A critical resource for a neglected parasite

Korhonen

Gasser

et al. 2020

PLoS Negl Trop Dis

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The parasitic mite Sarcoptes scabiei is an economically highly significant parasite of the skin of humans and animals worldwide. In humans, this mite causes a neglected tropical disease (NTD), called scabies. This disease results in major morbidity, disability, stigma and poverty globally and is often associated with secondary bacterial infections. Currently, anti-scabies treatments are not sufficiently effective, resistance to them is emerging and no vaccine is available. Here, we report the first high-quality genome and transcriptomic data for S . scabiei . The genome is 56.6 Mb in size, has a a repeat content of 10.6% and codes for 9,174 proteins. We explored key molecules involved in development, reproduction, host-parasite interactions, immunity and disease. The enhanced ‘omic data sets for S . scabiei represent comprehensive and critical resources for genetic, functional genomic, metabolomic, phylogenetic, ecological and/or epidemiological investigations, and will underpin the design and development of new treatments, vaccines and/or diagnostic tests.

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Section: Introductionmentioning

confidence: 99%

High-quality nuclear genome for Sarcoptes scabiei—A critical resource for a neglected parasite

Korhonen

Gasser

et al. 2020

PLoS Negl Trop Dis

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“…A manifestation of scabies mostly results in skin burrows, erythematous papules and generalized itching [ 5 ]. Secondary infections can lead to life-threatening complications including sepsis [ 6 ]. In 2017, the WHO recognized scabies as a neglected tropical disease [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of ivermectin mass-drug administration to control scabies in asylum seekers in the Netherlands: A retrospective cohort study between January 2014 – March 2016

Beeres

Ravensbergen

Heidema³

et al. 2018

PLoS Negl Trop Dis

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Scabies is a skin infestation with the mite Sarcoptes scabiei causing itch and rash and is a major risk factor for bacterial skin infections and severe complications. Here, we evaluated the treatment outcome of 2866 asylum seekers who received (preventive) scabies treatment before and during a scabies intervention programme (SIP) in the main reception centre in the Netherlands between January 2014 and March 2016. A SIP was introduced in the main national reception centre based on frequent observations of scabies and its complications amongst Eritrean and Ethiopian asylum seekers in the Netherlands. On arrival, all asylum seekers from Eritrea or Ethiopia were checked for clinical scabies signs and received ivermectin/permethrin either as prevention or treatment. A retrospective cohort study was conducted to compare the reinfestations and complications of scabies in asylum seekers who entered the Netherlands before and during the intervention and who received ivermectin/permethrin. In total, 2866 asylum seekers received treatment during the study period (January 2014 –March 2016) of which 1359 (47.4%) had clinical signs of scabies. During the programme, most of the asylum seekers with scabies were already diagnosed on arrival as part of the SIP screening (580 (64.7%) of the 897). Asylum seekers with more than one scabies episode reduced from 42.0% (194/462) before the programme to 27.2% (243/897) during the programme (RR = 0.64, 95% CI = 0.55–0.75). Development of scabies complications later in the asylum procedure reduced from 12.3% (57/462) to 4.6% (41/897). A scabies prevention and treatment programme at start of the asylum procedure was feasible and effective in the Netherlands; patients were diagnosed early and risk of reinfestations and complications reduced. To achieve a further decrease of scabies, implementation of the programme in multiple asylum centres may be needed.

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“…In hyperendemic tropical regions, the link with secondary bacterial infections is increasingly recognized. Group A streptococcal and staphylococcal pyoderma can cause bacteraemia, glomerulonephritis and acute rheumatic fever, potentially leading to rheumatic heart disease. Current scabies treatments are few in number and suboptimal.…”

mentioning

confidence: 99%

In vitro ovicidal activity of current and under‐development scabicides: which treatments kill scabies eggs?

Bernigaud

Fernando

et al. 2019

Br J Dermatol

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Scabies and mortality

Cited by 50 publications

References 4 publications

High-quality nuclear genome for Sarcoptes scabiei—A critical resource for a neglected parasite

High-quality nuclear genome for Sarcoptes scabiei—A critical resource for a neglected parasite

Efficacy of ivermectin mass-drug administration to control scabies in asylum seekers in the Netherlands: A retrospective cohort study between January 2014 – March 2016

In vitro ovicidal activity of current and under‐development scabicides: which treatments kill scabies eggs?

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