Scabronine G Methyl Ester Improves Memory-Related Behavior and Enhances Hippocampal Cell Proliferation and Long-Term Potentiation via the BDNF-CREB Pathway in Olfactory Bulbectomized Mice

Nakagawasai, Osamu; Lin, Jia Rong; Odaira, Takayo; Takahashi, Kohei; Nemoto, Wataru; Moriguchi, Shigeki; Yabuki, Yasushi; Kobayakawa, Yu; Fukunaga, Kohji; Nakada, Masahisa; Tanno, Koichi

doi:10.3389/fphar.2020.583291

Cited by 16 publications

(6 citation statements)

References 77 publications

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“…Studies have suggested that the function of p-CREB is strongly linked to long-term potentiation (LTP) and synaptic plasticity, which play vital roles in the processes involved in memory creation and preservation. 3 The present investigation revealed that the DHF and MSFT combined treatment led to a substantial increase in the concentrations of BDNF, VGF, PSD-95, Nrf2, p-Ser9-GSK3β and p-CREB proteins in the hippocampus of Aβ-induced mice. However, DHF alone can only increase the expressions of BDNF, PSD95 and Nrf2, while MSFT alone can only increase the expressions of BDNF and VGF.…”

Section: Discussionsupporting

confidence: 48%

Multisensory Fusion Training and 7, 8-Dihydroxyflavone Improve Amyloid-β-Induced Cognitive Impairment, Anxiety, and Depression-Like Behavior in Mice Through Multiple Mechanisms

Guo,

Cao,

Zhang

et al. 2024

NDT

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Section: Discussionsupporting

confidence: 48%

Multisensory Fusion Training and 7, 8-Dihydroxyflavone Improve Amyloid-β-Induced Cognitive Impairment, Anxiety, and Depression-Like Behavior in Mice Through Multiple Mechanisms

Guo,

Cao,

Zhang

et al. 2024

NDT

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“…In 2VO rats subjected to a two-week EA intervention, in vivo electrophysiological techniques were used to examine the characteristics of LTP in the DG area of the hippocampus after surgery in each group, resulting in LTP damage in the DG area being significantly attenuated in the VCI group and significantly reduced in the EA group [ 46 ]. Previous studies have reported that the immediate effect of EA increases LTP in the DG region of the rat hippocampus [ 47 ]. Our results showed that the LTP of the EA group was significantly higher than that of the 2VO and NA groups.…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture Increases the Hippocampal Synaptic Transmission Efficiency and Long-Term Plasticity to Improve Vascular Cognitive Impairment

Dai

Zhang

Yang

et al. 2022

Mediators of Inflammation

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Studies have shown that electroacupuncture (EA) can effectively improve vascular cognitive impairment (VCI), but its mechanisms have not been clearly elucidated. This study is aimed at investigating the mechanisms underlying the effects of EA treatment on hippocampal synaptic transmission efficiency and plasticity in rats with VCI. Methods. Sprague–Dawley rats were subjected to VCI with bilateral common carotid occlusion (2VO). EA stimulation was applied to Baihui (GV20) and Shenting (GV24) acupoints for 30 min once a day, five times a week, for four weeks. Our study also included nonacupoint groups to confirm the specificity of EA therapy. The Morris water maze (MWM) was used to assess cognitive function. Electrophysiological techniques were used to detect the field characteristics of the hippocampal CA3–CA1 circuit in each group of rats, including input-output (I/O), paired-pulse facilitation ratios (PPR), field excitatory postsynaptic potential (fEPSP), and excitatory postsynaptic current (EPSC). The expression of synapse- and calcium-mediated signal transduction associated proteins was detected through western blotting. Results. The MWM behavioural results showed that EA significantly improved cognitive function in VCI model rats. EA increased the I/O curve of VCI model rats from 20 to 90 μA. No significant differences were observed in hippocampal PPR. The fEPSP of the hippocampal CA3–CA1 circuit was significantly increased after EA treatment compared with that after nonacupuncture treatment. We found that EA led to an increase in the EPSC amplitude and frequency, especially in the decay and rise times. In addition, the protein expression and phosphorylation levels of N-methyl-D-aspartate receptor 2B, α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor 1, and Ca2+-calmodulin-dependent protein kinase II increased to varying degrees in the hippocampus of VCI model rats. Conclusion. EA at GV20 and GV24 acupoints increased the basic synaptic transmission efficiency and synaptic plasticity of the hippocampal CA3–CA1 circuit, thereby improving learning and memory ability in rats with VCI.

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“…A previous report indicated that tyrosine kinase B, a BDNF receptor, was decreased in the hippocampus of individuals with psychiatric disorders [ 59 ]. The hippocampal BDNF/cAMP-responsive element-binding protein signaling pathway has also been related to cognitive function [ 60 ]. Thus, future studies should investigate other salivary biomarkers and the expression of tyrosine kinase B and cAMP-responsive element-binding protein, alongside its relation to BDNF polymorphisms, which influence neurodegeneration in the hippocampus, and salivary metabolites.…”

Section: Discussionmentioning

confidence: 99%

Cognitive Dysfunction in a Mouse Model of Cerebral Ischemia Influences Salivary Metabolomics

Sugimoto

Saruta

et al. 2021

JCM

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Vascular dementia, caused by cerebrovascular disease, is associated with cognitive impairment and reduced hippocampal metabolite levels. Specifically, cognitive impairment can be induced by decreased hippocampal brain-derived neurotrophic factor (BDNF) expression. The development of low or non-invasive biomarkers to characterize these diseases is an urgent task. Disturbance of metabolic pathways has been frequently observed in cognitive impairment, and salivary molecules also showed the potentials to reflect cognitive impairment. Therefore, we evaluated salivary metabolic profiles associated with altered hippocampal BDNF expression levels in a cerebral ischemia mouse model using metabolomic analyses. The effect of tacrine (a cholinesterase inhibitor) administration was also examined. The arteries of ICR mice were occluded with aneurysm clips to generate the cerebral ischemia model. Learning and memory performance was assessed using the elevated plus maze (EPM) test. Hippocampal and blood BDNF levels were quantified using an enzyme-linked immunosorbent assay. Glutamate decarboxylase 1 (GAD1) mRNA expression, is associated with cognitive impairment, was quantified by a real-time polymerase chain reaction. The EPM test revealed impaired spatial working memory in the cerebral ischemia mouse model; tacrine administration ameliorated this memory impairment. Cerebral ischemia suppressed GAD1 expression by decreasing hippocampal BDNF expression. In total, seven salivary metabolites, such as trimethylamine N-oxide and putrescine, were changed by cognitive impairment and tacrine administration. Our data suggest that salivary metabolite patterns were associated with cognitive function.

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Scabronine G Methyl Ester Improves Memory-Related Behavior and Enhances Hippocampal Cell Proliferation and Long-Term Potentiation via the BDNF-CREB Pathway in Olfactory Bulbectomized Mice

Cited by 16 publications

References 77 publications

Multisensory Fusion Training and 7, 8-Dihydroxyflavone Improve Amyloid-β-Induced Cognitive Impairment, Anxiety, and Depression-Like Behavior in Mice Through Multiple Mechanisms

Multisensory Fusion Training and 7, 8-Dihydroxyflavone Improve Amyloid-β-Induced Cognitive Impairment, Anxiety, and Depression-Like Behavior in Mice Through Multiple Mechanisms

Electroacupuncture Increases the Hippocampal Synaptic Transmission Efficiency and Long-Term Plasticity to Improve Vascular Cognitive Impairment

Cognitive Dysfunction in a Mouse Model of Cerebral Ischemia Influences Salivary Metabolomics

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