Scaffold based on castor oil as an osteoconductive matrix in bone repair: biocompatibility analysis

Abstract

To analyze the biocompatibility of the scaffold produced from a natural polymer derived from castor oil through hemolytic activity and antimicrobial activity, to enable the clinical application. Three in vitro tests were performed: Hemolytic activity test -Polymer partially dissolved in contact with blood agar; Hemolytic activity test in sheep's blood -Polymer extract with red blood cells solution; Antimicrobial activity test -Solid polymer in direct contact with E. Coli and S. Aureus. For hemolytic tests, none of the samples showed hemolysis. Negative hemolytic activity is a good indicator, as the maintenance of the blood clot in the area of the lesion is essential for the formation of new tissue. For the antimicrobial activity test, no significant activity was observed against the bacteria used. The polymer is not toxic to red blood cells, being viable for clinical application as a matrix for tissue regeneration.

Surface and micromechanical analysis of polyurethane plates with hydroxyapatite for bone structure

“…In this sense, biopolymers of plant origin have been used for developing products to the biomedical field, including polyurethane [3][4][5][6][7][8] . Polyurethane from castor oil is a compound that consists of a prepolymer and a polyol extracted from the seed oil of the Ricinus communis plant, which does not exude toxic vapors and is a biocompatible material [9,10] .…”