Scaffold design and characterisation for osteochondral tissue regeneration

Deplaine, H.

doi:10.4995/thesis/10251/14638

Cited by 1 publication

(1 citation statement)

References 86 publications

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“…The essential requirement for scaffolds is biomaterials as they are designed to interact with biological tissues for augmenting or replacing a native tissue. They must be biocompatible, nonimmunogenic and if desirable, biodegradable; that is a biomaterial should perform safely within the biological environment and any degradation products should be nontoxic [4]. The natural polymers show excellent biocompatibility and biodegradability, low antigenicity.…”

Section: Introductionmentioning

confidence: 99%

Development, Characterization, and Evaluation of the Antimicrobial Properties of Biodegradable Porous Scaffolds Loaded With Natural Vanillin

AKILA,

JANANI

2023

Int J Pharm Pharm Sci

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Objective: The study's objective is to create biodegradable porous scaffolds that are filled with natural vanillin and assess their in vitro antibacterial activity. Methods: Scaffolds were fabricated by blending different ratios of chitosan and gelatin along with vanillin using the freeze-drying method. Then the following characterization and evaluation of scaffolds, such as FTIR, SEM, porosity, swelling behaviour, degradation studies, in vitro drug release, and antibacterial studies, were carried out. Results: All of the scaffolds that were created had heterogeneous, well-connected pores and were pale yellow in color. This was validated by SEM, where the porosity is greater than 80% and the mean pore size ranges from 105.25±6.35 µm to 188.58±7.51 µm. With an increase in gelatin concentration, all of the scaffolds showed the maximum water absorption and retention capabilities of 760.15%±4.38% and 664.73%±5.82%. In the 7-day degradation investigation, all samples lost close to 60% of their mass. In the formulation CG11, the vanillin was released gradually over about 96 h. According to the present study, the developed scaffolds CG13-A and CG13-B, as well as CG11-A and CG11-B, displayed a higher zone of inhibition. Conclusion: Due to its potent antibacterial capabilities, it may be inferred from the current research that vanillin clothed in chitosan-gelatin scaffolds would be a superior option for treating various wound infections, including diabetic wounds.

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Section: Introductionmentioning

confidence: 99%