Scaffold-Scaffold Interaction Facilitates Cell Polarity Development in Caulobacter crescentus

Lü, Ning; Duvall, Samuel W.; Zhao, Guangjie; Kowallis, Kimberley A; Zhang, Chao; Tan, Winson Jianhong; Sun, Jiangtao; Petitjean, Haley N.; Tomares, Dylan T.; Zhao, Guoping; Childers, W. Seth; Zhao, Wei

doi:10.1128/mbio.03218-22

Cited by 1 publication

(1 citation statement)

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“…Once phosphorylated and active, CtrA promotes the transcription of over 90 developmental genes, many involved in the development of the new flagellar pole ( 65 ). Distinct biomolecular condensates positioned at the stalked and flagellar poles allow asymmetric localization of cellular components prior to cell division ( 66 – 69 ). Caulobacter’s bi-phasic cell cycle gives rise to two distinct sub-populations: planktonic swarmer cells and stationary stalked and pre-divisional cells.…”

Section: Obligate Differentiation Allows For Division Of Labor and Be...mentioning

confidence: 99%

Bacterial cell differentiation enables population level survival strategies

Chong,

Shapiro

2024

mBio

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Clonal reproduction of unicellular organisms ensures the stable inheritance of genetic information. However, this means of reproduction lacks an intrinsic basis for genetic variation, other than spontaneous mutation and horizontal gene transfer. To make up for this lack of genetic variation, many unicellular organisms undergo the process of cell differentiation to achieve phenotypic heterogeneity within isogenic populations. Cell differentiation is either an inducible or obligate program. Induced cell differentiation can occur as a response to a stimulus, such as starvation or host cell invasion, or it can be a stochastic process. In contrast, obligate cell differentiation is hardwired into the organism’s life cycle. Whether induced or obligate, bacterial cell differentiation requires the activation of a signal transduction pathway that initiates a global change in gene expression and ultimately results in a morphological change. While cell differentiation is considered a hallmark in the development of multicellular organisms, many unicellular bacteria utilize this process to implement survival strategies. In this review, we describe well-characterized cell differentiation programs to highlight three main survival strategies used by bacteria capable of differentiation: (i) environmental adaptation, (ii) division of labor, and (iii) bet-hedging.

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