Scalable classification of nanoparticles: A proof of principle for process design

Menter, Christina; Segets, Doris

doi:10.1016/j.apt.2019.08.027

Cited by 6 publications

(3 citation statements)

References 50 publications

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“…Also, the packed nature of the latter's responses is attributed to their geometrical structure and size. Similar observations were seen in other research [29][30][31]. The cytotoxic effect of NPs is also linked to their synthetic route, nature of the reducing agent, capping agent, the media in which they were cultivated and the chemicals being used [32] compared the effect of synthesising gold nanoparticles using citrate-and 11-mercaptoundecanoic acid (MUA).…”

Section: Cytotoxicity Of Nanoparticlessupporting

confidence: 71%

Toxicity and Cytotoxicity Effects of Selected Nanoparticles: A Review

Odaudu

Akinsiku

2022

IOP Conf. Ser.: Earth Environ. Sci.

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The appreciable development in nanotechnology has drawn the attention of several researchers cutting across different fields. However, some nanoparticles have been identified to possess harmful effects on humans and the environment. Hence, putting these cause and effect patterns into context is highly required for future research and discussions about nanotechnology. This study reviewed existing literature on the toxicity and cytotoxicity effects of some nanoparticles to compare reaction patterns. Many kinds of research used different cell cultures, including cancer cell lines, human endothelial cells, hepatic cells, which were tested both in vitro and in vivo to check the mechanism of the possible toxicity effects. Adverse effects of nanoparticles identified involved damaged DNA leading to mutations and generation of reactive oxygen species (ROS). The prominent identified common toxicity responses in nanoparticle-cell interaction were lysosomes formation interference, necrosis and apoptosis, nanoparticles and protein interaction, and agglomerate formation in other body parts. Some reports showed that the causes of these responses might be due to the physicochemical properties of the interrogated particles, such as particle size, shape, surface functionalisation, surface charge. Furthermore, nanoparticles’ toxicity effects are both concentration-dependent and time-dependent, highly pronounced in chemical or physical-based synthetic routes. Cytotoxic effects of nanoparticles were mainly linked to their synthetic method, nature of the reducing agent, and culture media.

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Section: Cytotoxicity Of Nanoparticlessupporting

confidence: 71%

Toxicity and Cytotoxicity Effects of Selected Nanoparticles: A Review

Odaudu

Akinsiku

2022

IOP Conf. Ser.: Earth Environ. Sci.

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“…The solution-like nature of nanoparticles in solvents makes it possible to use the tools and insights from the statistical thermodynamics of solutions and to apply them to rationalize experimental observations. Size-selective precipitation of nanoparticles is important not only in fabricating uniform-sized nanoparticle samples but also as a support for the single-phase nature of dispersions [64][65][66][67]. Especially important is the establishment of the partition coefficient, regardless of dispersant concentration, between dispersed and flocculated phases [66,67].…”

Section: Connection To Phase Diagram Solubility and Particle-particle Interactionmentioning

confidence: 99%

Thermodynamic stability condition can judge whether a nanoparticle dispersion can be considered a solution in a single phase

Shimizu

Matubayasi

2020

Journal of Colloid and Interface Science

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“…The down-streaming process for composite materials on a preparative scale are still cost-intensive because often technical approaches like liquid chromatography for molecular species cannot be transferred with the same efficiency to colloidal particles [7,8]. Three principles for the separation of the desired colloids and the excess synthesis components are recognized: distribution in size [9], polarity [10], and electrophoretic mobility [11]. Perturbating the dispersion of colloids by adding a weak solvent leads to agglomeration and precipitation of the nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Automated Quantum Dots Purification via Solid Phase Extraction

et al. 2022

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The separation of colloidal nanocrystals from their original synthesis medium is an essential process step towards their application, however, the costs on a preparative scale are still a constraint. A new combination of approaches for the purification of hydrophobic Quantum Dots is presented, resulting in an efficient scalable process in regard to time and solvent consumption, using common laboratory equipment and low-cost materials. The procedure is based on a combination of solvent-induced adhesion and solid phase extraction. The platform allows the transition from manual handling towards automation, yielding an overall purification performance similar to one conventional batch precipitation/centrifugation step, which was investigated by thermogravimetry and gas chromatography. The distinct miscibility gaps between surfactants used as nanoparticle capping agents, original and extraction medium are clarified by their phase diagrams, which confirmed the outcome of the flow chemistry process. Furthermore, the solubility behavior of the Quantum Dots is put into context with the Hansen solubility parameters framework to reasonably decide upon appropriate solvent types.

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Scalable classification of nanoparticles: A proof of principle for process design

Cited by 6 publications

References 50 publications

Toxicity and Cytotoxicity Effects of Selected Nanoparticles: A Review

Toxicity and Cytotoxicity Effects of Selected Nanoparticles: A Review

Thermodynamic stability condition can judge whether a nanoparticle dispersion can be considered a solution in a single phase

Automated Quantum Dots Purification via Solid Phase Extraction

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