Scale‐down of the Jet Zone Loop Reactor: Development of a Screening Tool for Chemical Reactions

Wiedemann, Mathias; Räbiger, Norbert; Schlüter, Michael; Eisenlauer, J.; Riener, Franz‐Xaver; Kutschera, D.; Neumann, Stefan

doi:10.1002/cite.201000098

Cited by 10 publications

(8 citation statements)

References 7 publications

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“…In these cases, it can be an adequate solution to provide even larger specific interfaces and enhance the mass transfer performance that way. Loop reactors and their derivatives have been proven to be excellent devices for this purpose [1][2][3][4]. As such, a jet loop reactor (JLR) is chosen as the tool for the desired process intensification.…”

Section: Introductionmentioning

confidence: 99%

Scale-Up Strategies of Jet Loop Reactors for the Intensification of Mass Transfer Limited Reactions

Maly

Schaper

Kuwertz³

et al. 2022

Processes

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For the purpose of the intensification of an industrial-scale gas-liquid process, the implementation in an alternative reactor concept is investigated at Hamburg University of Technology (TUHH) in cooperation with Ehrfeld Mikrotechnik GmbH. Existing process operation data from a bubble column hint at a mass transfer limitation of the gas-liquid reaction. In the project, a jet loop reactor (JLR) is chosen to increase the specific interfacial area between gas and liquid, and thus increase mass transfer, while keeping the reactor system mechanically simple and low-maintenance. For the investigation, a laboratory scale reactor has been designed on the basis of an existing industrial scale process and scaled according to a pilot scale reactor available at TUHH. For scaling, geometric similarity is desired, while specific energy dissipation rate and volumetric gas input are kept constant for the chosen scale-up strategy. Between the two different scales, the reactors are successfully characterised in a water-air system with regards to the important mass transfer, among other parameters. A pressure- and chemical-resistant twin of the laboratory-scale reactor is provided to the project partner for trials under real process conditions with the original material system. The presented work shows that the JLR concept can be transferred sufficiently well between different scales when suitable parameters are chosen, and offers a wide operating window. The investigations aim to provide a basis for a future scale-up of the chemical process in the JLR system to the industrial scale.

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Section: Introductionmentioning

confidence: 99%

Scale-Up Strategies of Jet Loop Reactors for the Intensification of Mass Transfer Limited Reactions

Maly

Schaper

Kuwertz³

et al. 2022

Processes

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“…Several studies reported in the last years that for large‐scale bulk chemical production a relationship between product quality and local mass transfer processes is present. However, these relationships could not be sufficiently explained or described until today . Examples for such reactions are the cumene oxidation, toluene oxidation (Scheme ) and also chlorination reactions …”

Section: Introductionmentioning

confidence: 99%

Reaction Systems for Bubbly Flows

et al. 2018

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Reactive bubbly flows are at the heart of multiphase flows which are a major topic in chemical engineering since many bulk chemicals are produced in bubbly flows. However, the factors determining product yield and selectivity are often subject of complicated mass transfer effects. Herein, we describe the latest developments in the detection of mass transfer [a] is holding a permanent position in the Herres-Pawlis group at RWTH Aachen University for advanced spectroscopy, density functional calculations and X-ray crystallography. He studied Chemistry at the University of Paderborn and finished his PhD thesis at TU Dortmund in 2011 on the coordination chemistry of late transition metals for catalysis and bioinorganic chemistry. Then, he moved to LMU Munich and turned to the theoretical description of N-donor transition metal systems with focus on copper-dioxygen chemistry. In 2013, he was awarded with the Römer-Postdoc Prize.

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“…The achievable space time yields of biochemical reactions are determined by both, local mass transfer effects and the overall mass transfer capacity of the reactor . If high local reaction rates are achieved an efficient homogenization is required, otherwise oxygen and substrate gradients are formed and the aspired selectivity cannot be met . Already a few seconds of oxygen limitation can induce genes for a metabolic shift towards the production of anaerobic byproducts .…”

Section: Introductionmentioning

confidence: 99%

“…For JLRs, the efficient mass transfer performance relies on high local power inputs within the nozzle and subsequently the generation of a fine primary gas liquid dispersion . In case of the STR, mixing and the secondary dispersion of the gas phase is taking place at multiple stirrer blades and at the installed baffles.…”

Section: Introductionmentioning

confidence: 99%

Monitoring gradient formation in a jet aerated bioreactor

Weber

Schaepe

Freyer

et al. 2018

Engineering in Life Sciences

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Jet aerated loop reactors (JLRs) provide high mass transfer coefficients (kLa) and can be used for the intensification of mass transfer limited reactions. The jet loop reactor achieves higher kLa values than a stirred tank reactor (STR). The improvement relies on significantly higher local power inputs (∼104) than those obtainable with the STR. Operation at high local turnover rates requires efficient macromixing, otherwise reactor inhomogeneities might occur. If sufficient homogenization is not achieved, the selectivity of the reaction and the respective yields are decreased. Therefore, the balance between mixing and mass transfer in jet loop reactors is a critical design aspect. Monitoring the dissolved oxygen levels during the turnover of a steady sodium sulfite feed implied the abundance of gradients in the JLR. Prolonged mixing times at identical power input and aeration rates (∼100%) were identified for the JLR in comparison to the STR. The insertion of a draft tube to the JLR led to a more homogenous dissolved oxygen distribution, but unfortunately a reduction of mixing time was not achieved. In case of increased medium viscosities as they may arise in high cell density cultivations, no gradient formation was detected. However, differences in medium viscosity significantly altered the mass transfer and mixing performance of the JLR.

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Scale‐down of the Jet Zone Loop Reactor: Development of a Screening Tool for Chemical Reactions

Cited by 10 publications

References 7 publications

Scale-Up Strategies of Jet Loop Reactors for the Intensification of Mass Transfer Limited Reactions

Scale-Up Strategies of Jet Loop Reactors for the Intensification of Mass Transfer Limited Reactions

Reaction Systems for Bubbly Flows

Monitoring gradient formation in a jet aerated bioreactor

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