Scale-up from laboratory microfiltration to a ceramic pilot plant: Design and performance

Baruah, Gautam Lal; Nayak, Arpan Kumar; Belfort, Georges

doi:10.1016/j.memsci.2005.07.046

Cited by 45 publications

(37 citation statements)

References 9 publications

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“…The isoelectric point (pI) of IgG is about 5.8-7.5 (Baruah et al, 2006;Hahn et al, 1998;Hemmings and Jones, 1974). Working at a pH value 1 unit greater than pI, the IgG carries a net negative surface charge and will bind to an anion-exchange stationary phase (Staby et al, 2000;Staby and Jensen, 2001).…”

Section: Effect Of Poly(metac) Chain Density On the Dynamic Binding Cmentioning

confidence: 99%

The role of polymer nanolayer architecture on the separation performance of anion‐exchange membrane adsorbers: I. Protein separations

Bhut

Weaver

Carter

et al. 2011

Biotech & Bioengineering

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This contribution describes the preparation of strong anion-exchange membranes with higher protein binding capacities than the best commercial resins. Quaternary amine (Q-type) anion-exchange membranes were prepared by grafting polyelectrolyte nanolayers from the surfaces of macroporous membrane supports. A focus of this study was to better understand the role of polymer nanolayer architecture on protein binding. Membranes were prepared with different polymer chain graft densities using a newly developed surface-initiated polymerization protocol designed to provide uniform and variable chain spacing. Bovine serum albumin and immunoglobulin G were used to measure binding capacities of proteins with different size. Dynamic binding capacities of IgG were measured to evaluate the impact of polymer chain density on the accessibility of large size protein to binding sites within the polyelectrolyte nanolayer under flow conditions. The dynamic binding capacity of IgG increased nearly linearly with increasing polymer chain density, which suggests that the spacing between polymer chains is sufficient for IgG to access binding sites all along the grafted polymer chains. Furthermore, the high dynamic binding capacity of IgG (>130 mg/mL) was independent of linear flow velocity, which suggests that the mass transfer of IgG molecules to the binding sites occurs primarily via convection. Overall, this research provides clear evidence that the dynamic binding capacities of large biologics can be higher for well-designed macroporous membrane adsorbers than commercial membrane or resin ion-exchange products. Specifically, using controlled polymerization leads to anion-exchange membrane adsorbers with high binding capacities that are independent of flow rate, enabling high throughput. Results of this work should help to accelerate the broader implementation of membrane adsorbers in bioprocess purification steps.

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Section: Effect Of Poly(metac) Chain Density On the Dynamic Binding Cmentioning

confidence: 99%

The role of polymer nanolayer architecture on the separation performance of anion‐exchange membrane adsorbers: I. Protein separations

Bhut

Weaver

Carter

et al. 2011

Biotech & Bioengineering

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show abstract

“…[5]). Ceramic membranes of 1.4 m pore size showed no retention of milk proteins [6], whereas improved flux and small whey protein retention were measured with 0.14 m ceramic membranes at high cross-flow velocity [7].…”

Section: Introductionmentioning

confidence: 99%

Whey protein fouling of large pore-size ceramic microfiltration membranes at small cross-flow velocity

Mourouzidis-Mourouzis

Karabelas

2008

Journal of Membrane Science

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“…Bactocatch process, developed by Alfa-Laval [32] and the patent now owned by Tetra Laval, as a milder pasteurization method employs a MF membrane of 1.4 μm, operated under UTMP condition. Typical operation conditions are UTMP of less than 0.5 bar and very high CF velocities of 6-8 ms -1 [17,33]. Bactocatch process is illustrated in Figure 7.…”

Section: Membrane Separations For Removal Of Microorganismsmentioning

confidence: 99%

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2017

JABB

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The use of membrane technology as a processing and separation method in food industry is gaining wide application. Membrane separations can be used either as alternatives to conventional techniques or as novel technology for processing new ingredients and foods. Membrane separations are considered green technologies. In many cases, membrane processes are more advantageous than traditional technologies. For example, using cold pasteurization and sterilization with suitable membranes instead of high temperature treatment for the removal of microorganisms is more economical in terms of energy consumption. Using membrane filtration to remove microorganisms for shelf-life extension of foods instead of using additives and preservatives also create a green image for the processed foods as well as for the processing procedure. Concentration by membrane filtration instead of thermal evaporation does not employ severe heating and that it preserves the natural taste of food products and the nutritional value of heat-sensitive components. The recovery of valuable components in diluted effluents and wastewater treatment applications are among the most useful and currently active aspects of membrane technology. Pressure-driven membrane processes, namely MF, UF, NF and RO facilitate separation of components with a large range of particle sizes. It is for this reason that they find wide range of applications in food processing industry. The first part of this manuscript is to give introduction about very basic knowledge in membrane separation technology. More importantly, this review presents up-to-date commercial and potential applications of pressure-driven membrane separation processes in dairy processing industry. Keywords: Introduction Theory of membrane separationsPressure-driven membrane processes: The pressure-driven membrane processes include microfiltration (MF), ultrafiltration (UF), nanofiltration (NF), and reverse osmosis (RO). When a feed is introduced to a membrane separation system it is separated into retentate (sometimes called concentrate), the fraction that is retained by the membrane, and permeate (also called filtrate), the fraction that passes through the membrane. The products of interest can either be in the retentate or in permeate or in both streams. The word 'pressure-driven' means that the main driving force for separation of these processes is transmembrane pressure (TMP), which is the pressure discrepancy between retentate sides and permeate side. Generally speaking, the pore sizes (or MWCO-molecular weight cut-off in cases of NF and RO) of membranes decrease in the order from MF to RO (Figure 1). However, the separation principle is not based on the pore sizes alone. Especially in UF and NF the charge of the molecules/solutes and their affinity for the filtering membrane are also important [1]. MF is normally used for separation of suspended particles and microorganisms from soluble components in feed. UF can be applied to separate soluble macromolecules such as proteins and peptides. NF...

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Scale-up from laboratory microfiltration to a ceramic pilot plant: Design and performance

Cited by 45 publications

References 9 publications

The role of polymer nanolayer architecture on the separation performance of anion‐exchange membrane adsorbers: I. Protein separations

The role of polymer nanolayer architecture on the separation performance of anion‐exchange membrane adsorbers: I. Protein separations

Whey protein fouling of large pore-size ceramic microfiltration membranes at small cross-flow velocity

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