Scanning laser polarimetry – a review

Pozzo, Stefano Da; Marchesan, Roberta; Ravalico, Giuseppe

doi:10.1111/j.1442-9071.2008.01891.x

Cited by 18 publications

(14 citation statements)

References 43 publications

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“…The newest SLP version, the GDx ECC with enhanced corneal compensator13 25 reduces atypical retardation patterns (ARPs) measured by TSS 18 26 27. The ability of SLP to discriminate between healthy and glaucomatous eyes has been shown to decrease when ARPs are present 6 17 28. Moreover, ARPs are not necessarily stable over time,18 and can therefore either mask true progressing eyes (if ARP increases over time) or cause the GPA to detect false progression (if ARP decreases over time).…”

Section: Discussionmentioning

confidence: 99%

Detection of retinal nerve fibre layer progression: comparison of the fast and extended modes of GDx guided progression analysis

Kjaergaard

Alencar

Nguyen

et al. 2011

British Journal of Ophthalmology

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Purpose To compare detection of retinal nerve fiber layer (RNFL) changes using GDx Guided Progression Analysis (GPA) fast mode (which assumes fixed variability of a reference population) and extended mode (which measures individual variability) and to determine how they compare to photography and visual field based conventional methods for identifying glaucoma progression. Methods 172 eyes from 117 participants in the Diagnostic Innovations in Glaucoma Study (DIGS) (12 healthy, 108 glaucoma suspect and 52 glaucoma eyes) with ≥4 GDx VCC visits and ≥3 good quality GDx VCC scans at each visit were included. Results: Agreement between the GDx GPA fast mode and GDx GPA extended mode was limited. The GDx fast mode and extended mode detected 15 and 18 eyes, respectively as “likely progression” but only 7 of them agreed. The conventional reference standard (stereophotograph based optic disc and/or visual field progression) identified 9 eyes as progressing of which 2 eyes were also identified by the GDx fast and 3 eyes by the extended mode. In the GDx fast mode, we found that the progression detection varies depending on which 2 scans are included in the baseline and follow-up images. Conclusion: There was limited agreement between the GDx fast mode and the GDx extended mode for progression detection, and between different scans included in the GDx fast mode progression analysis. Longer follow-up is needed to determine the proportion of eyes classified as “likely progression” by the GDx analysis that are early change and the proportion that are false positive results.

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Section: Discussionmentioning

confidence: 99%

Detection of retinal nerve fibre layer progression: comparison of the fast and extended modes of GDx guided progression analysis

Kjaergaard

Alencar

Nguyen

et al. 2011

British Journal of Ophthalmology

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“…[1, 2] During the past decade, several objective, quantitative methods have been introduced to assess these structural changes in the optic disc and the retinal nerve fiber layer. These include red-free fundus photography, [3, 4] stereo photography, [5] scanning laser polarimetry, [6] confocal scanning laser ophthalmoscopy (Heidelberg retinal tomography: HRT), and optical coherence tomography (OCT) [2, 7–9]. Measurement parameters of optic disc cupping have shown that it is significantly associated with glaucoma severity and that, interestingly, cupping precedes visual field loss.…”

Section: Introductionmentioning

confidence: 99%

OCT-Based Quantification and Classification of Optic Disc Structure in Glaucoma Patients

et al. 2016

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PurposeTo objectively classify the optic discs of open-angle glaucoma (OAG) patients into Nicolela's four disc types, i.e., focal ischemic (FI), myopic (MY), senile sclerotic (SS), and generalized enlargement (GE), with swept-source optical coherence tomography (SS-OCT).MethodsThis study enrolled 113 eyes of 113 OAG patients (mean age: 62.5 ± 12.6; Humphrey field analyzer-measured mean deviation: -9.4 ± 7.3 dB). Newly developed software was used to quantify a total of 20 optic disc parameters in SS-OCT (DRI OCT-1, TOPCON) images of the optic disc. The most suitable reference plane (RP) above the plane of Bruch’s membrane opening was determined by comparing, at various RP heights, the SS-OCT-measured rim parameters and spectral-domain OCT-measured circumpapillary retinal nerve fiber layer thickness (cpRNFLT), with Pearson's correlation analysis. To obtain a discriminant formula for disc type classification, a training group of 72 eyes of 72 OAG patients and a validation group of 60 eyes of 60 OAG patients were set up.ResultsCorrelation with cpRNFLT differed with disc type and RP height, but overall, a height of 120 μm minimized the influence of disc type. Six parameters were most significant for disc type discrimination: disc angle (horizontal), average cup depth, cup/disc ratio, rim-decentering ratio, average rim/disc ratio (upper and lower nasal). Classifying the validation group with these parameters returned an identification rate of 80.0% and a Cohen’s Kappa of 0.73.ConclusionOur new, objective SS-OCT-based method enabled us to classify glaucomatous optic discs with high reproducibility and accuracy.

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“…GDx is known to be useful in detecting progressive RNFL thinning in primary open angle glaucoma as highlighted by Grewall et al [31], Reus et al [32], Toth et al [33], and summarised by Da Pozzo et al in their review of SLP [34]. Similarly, previous findings have reported that GDx is able to highlight superior and inferior RNFL defects 16 weeks after APAC [35].…”

Section: Gdx Evidence Of Damagementioning

confidence: 74%

Objective Assessment of Progression after Acute Primary Angle Closure Using HRT and GDx

Normando¹

2015

J Clin Exp Ophthalmol

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Irreversible damage to the optic nerve can follow the rapid increase of IOP during an acute primary angle closure (APAC). Despite the development of advanced imaging technology, there is still a lack of good longitudinal studies assessing patients after an acute attack. The aim of this study was to assess the progression of patients using different objective optic nerve head and retinal imaging parameters following APAC.Twenty patients with a single attack of APAC, were retrospectively assessed in this study. Patients were assessed with the Heidelberg retinal tomography (HRT3) and scanning laser polarimeter (GDx-VCC) as well as Humphrey visual field (HVF) repeatedly up to eighteen months after the acute attack. Progression for each imaging modality was assessed with multiple parameters.All patients showed retinal nerve fibre layer (RNFL) and optic disc changes over time. At 18 months, 67% of patients showed progression in 4/5 GDx parameters, and 33% in all 5. HRT analysis similarly showed progression in 4/5 parameters in 70% of patients, and 30% in all 5.This study shows that structural progressive changes to RNFL and ONH occur following APAC confirming that APAC patients need long-term follow-up after the acute attack.

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Scanning laser polarimetry – a review

Cited by 18 publications

References 43 publications

Detection of retinal nerve fibre layer progression: comparison of the fast and extended modes of GDx guided progression analysis

Detection of retinal nerve fibre layer progression: comparison of the fast and extended modes of GDx guided progression analysis

OCT-Based Quantification and Classification of Optic Disc Structure in Glaucoma Patients

Objective Assessment of Progression after Acute Primary Angle Closure Using HRT and GDx

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