Scar Tissue Carcinoma

Ms, Arons; Ae, Rodin; Jb, Lynch; Lewis, Camille Kaminski; Tg, Blocker

doi:10.1097/00000658-196603000-00018

Cited by 49 publications

(10 citation statements)

References 11 publications

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“…This underscores the need for the surgical evaluation of chronic wounds and scars. Theories of carcinogenesis of Marjolin's ulcer vary from the description of chronic irritation to atypia and to carcinoma in the study by Arons et al11 Newer theories included induction of dominant neoplastic cells, radiation, toxic alteration of mitosis, and implantation of epidermal cells into dermis 12…”

Section: Discussionmentioning

confidence: 99%

Basal cell carcinoma in five albino Africans from the south‐eastern equatorial rain forest of Nigeria

et al. 2007

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Section: Discussionmentioning

confidence: 99%

Basal cell carcinoma in five albino Africans from the south‐eastern equatorial rain forest of Nigeria

et al. 2007

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“…1963, Lazar and Cullen 1963, Traenkle 1963, Arons et al 1965, Conway and Hugo 1966, Moller et al 1979, Afzelius et al . Evidence suggests that mucocutaneous SCC (e .g .…”

Section: 1 Scc Metastasis Ratesmentioning

confidence: 99%

Overview of Radiation-induced Skin Cancer in Humans

Shore

1990

International Journal of Radiation Biology

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There are about a dozen studies of the incidence of skin cancer among irradiated populations with known skin doses that are available for estimating the risk of radiation-induced skin cancer. It is of note that they provide no evidence for a dose threshold and are compatible with a linear dose-response relationship, at least for ultraviolet radiation exposed skin. The studies also provide varying amounts of evidence concerning a number of other important issues in assessing skin cancer risk: types of skin cancer induced by ionizing radiation, the appropriateness of relative risk vs absolute risk models, combined effects of ionizing and UV radiations, and variations in sensitivity to skin cancer induction among demographic and genetic subgroups. Little epidemiological information is available on several factors, such as the RBE for high-LET radiation, the effects of dose protraction or fractionation, or variations in risk by age at irradiation. A reasonable estimate of skin cancer lethality was 0.2 per cent when weighted for the relative proportions of squamous cell and basal cell skin cancers. Average risk estimates of radiation-induced skin cancer incidence were: absolute risk (AR) of 8.5 X 10(-4) person-year-Sv and excess relative risk (RR) of 52 per cent/Sv. Lifetime skin cancer risk was calculated by life-table methods for males from exposures spread out over ages 20-60 years. The estimates for excess skin cancer incidence were 2 per cent and 11 per cent per Sv under the AR and RR models, respectively, while the corresponding mortality risks were 4 X 10(-5) and 2 X 10(-4) per Sv.

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“…Malignant change has been recorded in cases of all long-standing sinuses, fistulae, scars, burns, ulcers and osteomyelitis (Arons et al, 1965). These authors illustrated a case of squamous carcinoma occurring in a 32-year-old white patient with a 7-year history of pilonidal sinus.…”

Section: Treatmentmentioning

confidence: 99%