Scavenger Receptors as Biomarkers and Therapeutic Targets in Cardiovascular Disease

Cuthbert, Gary Andrew; Shaik, Faheem; Harrison, Michael A.; Ponnambalam, Sreenivasan; Homer‐Vanniasinkam, Shervanthi

doi:10.3390/cells9112453

Cited by 15 publications

(6 citation statements)

References 176 publications

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“… 4 Several SRs are also located inside the cell. A detailed description of the structures and classes of SRs has been summarized in several reviews, 2 , 5 and a brief introduction to these SRs is also shown in Figure 1 (structure and location) and Table 1 (genetic locus and ligands).…”

mentioning

confidence: 99%

Scavenger Receptors in Myocardial Infarction and Ischemia/Reperfusion Injury: The Potential for Disease Evaluation and Therapy

Zhang

Wen

Liu

et al. 2023

JAHA

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Scavenger receptors (SRs) are a structurally heterogeneous superfamily of evolutionarily conserved receptors that are divided into classes A to J. SRs can recognize multiple ligands, such as modified lipoproteins, damage‐associated molecular patterns, and pathogen‐associated molecular patterns, and regulate lipid metabolism, immunity, and homeostasis. According to the literature, SRs may play a critical role in myocardial infarction and ischemia/reperfusion injury, and the soluble types of SRs may be a series of promising biomarkers for the diagnosis and prognosis of patients with acute coronary syndrome or acute myocardial infarction. In this review, we briefly summarize the structure and function of SRs and discuss the association between each SR and ischemic cardiac injury in patients and animal models in detail. A better understanding of the effect of SRs on ischemic cardiac injury will inspire novel ideas for therapeutic drug discovery and disease evaluation in patients with myocardial infarction.

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mentioning

confidence: 99%

Scavenger Receptors in Myocardial Infarction and Ischemia/Reperfusion Injury: The Potential for Disease Evaluation and Therapy

Zhang

Wen

Liu

et al. 2023

JAHA

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“…COLEC12 is principally present in cells of placental, stromal, and macrophage origin, and plays a role in cell-to-cell adhesion, similarly to selectins [ 71 ]. Despite SRs exerting a relevant role in cardiovascular diseases [ 72 , 73 ], COLEC12 is under-investigated in vessels and its detection in vascular endothelial cells [ 74 ] is controversial [ 75 ]. COLEC12 is consistently reduced in SMCs exposed to CSC and we may suppose that such a decline could diminish the SMC reciprocal interaction in vitro, thus facilitating cell migration.…”

Section: Resultsmentioning

confidence: 99%

Smooth Muscle Cell Phenotypic Switch Induced by Traditional Cigarette Smoke Condensate: A Holistic Overview

Bianchi

Damiani

Castiglioni

et al. 2023

IJMS

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Cigarette smoke (CS) is a risk factor for inflammatory diseases, such as atherosclerosis. CS condensate (CSC) contains lipophilic components that may represent a systemic cardiac risk factor. To better understand CSC effects, we incubated mouse and human aortic smooth muscle cells (SMCs) with CSC. We evaluated specific markers for contractile [i.e., actin, aortic smooth muscle (ACTA2), calponin-1 (CNN1), the Kruppel-like factor 4 (KLF4), and myocardin (MYOCD) genes] and inflammatory [i.e., IL-1β, and IL-6, IL-8, and galectin-3 (LGALS-3) genes] phenotypes. CSC increased the expression of inflammatory markers and reduced the contractile ones in both cell types, with KLF4 modulating the SMC phenotypic switch. Next, we performed a mass spectrometry-based differential proteomic approach on human SMCs and could show 11 proteins were significantly affected by exposition to CSC (FC ≥ 2.7, p ≤ 0.05). These proteins are active in signaling pathways related to expression of pro-inflammatory cytokines and IFN, inflammasome assembly and activation, cytoskeleton regulation and SMC contraction, mitochondrial integrity and cellular response to oxidative stress, proteostasis control via ubiquitination, and cell proliferation and epithelial-to-mesenchymal transition. Through specific bioinformatics resources, we showed their tight functional correlation in a close interaction niche mainly orchestrated by the interferon-induced double-stranded RNA-activated protein kinase (alternative name: protein kinase RNA-activated; PKR) (EIF2AK2/PKR). Finally, by combining gene expression and protein abundance data we obtained a hybrid network showing reciprocal integration of the CSC-deregulated factors and indicating KLF4 and PKR as the most relevant factors.

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“…Scavenger receptors are a group of molecules on the surface of macrophages, including class A (SR‐AI/II), class B (SR‐BI/CD36), and class E (LOX‐1) scavenger receptor (Cuthbert et al, 2020). Studies have shown that CD36 is the major receptor for ox‐LDL uptake by macrophages (Collot‐Teixeira et al, 2007; Cuthbert et al, 2020). The maximum binding ratio of ox‐LDL to macrophages decreased by 40% in CD36‐deficient individuals, and the incidence of atherosclerosis was lower than that in normal individuals.…”

Section: Regulation Of Lipid Metabolism By Pparγmentioning

confidence: 99%

Section: Regulation Of Lipid Metabolism By Pparγmentioning

confidence: 99%

The role of peroxisome proliferator‐activated receptor γ in lipid metabolism and inflammation in atherosclerosis

Yang

Shang

2023

Cell Biology International

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Cardiovascular disease events are the result of functional and structural abnormalities in the arteries and heart. Atherosclerosis is the main cause and pathological basis of cardiovascular diseases. Atherosclerosis is a multifactorial disease associated with dyslipidemia, inflammation, and oxidative stress, among which dyslipidemia and chronic inflammation occur in all processes. Under the influence of lipoproteins, the arterial intima causes inflammation, necrosis, fibrosis, and calcification, leading to plaque formation in specific parts of the artery, which further develops into plaque rupture and secondary thrombosis. Foam cell formation from macrophages is an early event in the development of atherosclerosis. Lipid uptake causes a vascular inflammatory response, and persistent inflammatory infiltration in the lesion area further promotes the development of the disease. Inhibition of macrophage differentiation into foam cell and reduction of the level of proinflammatory factors in macrophages can effectively alleviate the occurrence and development of atherosclerosis. Peroxisome proliferator-activated receptor γ (PPARγ) is a ligandactivated nuclear receptor that plays an important antiatherosclerotic role by regulating triglyceride metabolism, lipid uptake, cholesterol efflux, macrophage polarity, and inhibiting inflammatory signaling pathways. In addition, PPARγ shifts its binding to ligands and co-activators or co-repressors of transcription of target genes through posttranslational modification, thereby affecting the regulation of its downstream target genes. Many ligand agonists have also been developed targeting PPARγ. In this review, we summarized the role of PPARγ in lipid metabolism and inflammation in development of atherosclerosis, the posttranslational regulatory mechanism of PPARγ, and further discusses the value of PPARγ as an antiatherosclerosis target.

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Scavenger Receptors as Biomarkers and Therapeutic Targets in Cardiovascular Disease

Cited by 15 publications

References 176 publications

Scavenger Receptors in Myocardial Infarction and Ischemia/Reperfusion Injury: The Potential for Disease Evaluation and Therapy

Scavenger Receptors in Myocardial Infarction and Ischemia/Reperfusion Injury: The Potential for Disease Evaluation and Therapy

Smooth Muscle Cell Phenotypic Switch Induced by Traditional Cigarette Smoke Condensate: A Holistic Overview

The role of peroxisome proliferator‐activated receptor γ in lipid metabolism and inflammation in atherosclerosis

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