Scavenging and metal chelating potential of Carthamus tinctorius L. extracts

Dehariya, Rashmi; Chandrakar, Jagriti; Dubey, Satish; Ojha, Kundan; Dixit, Ashwini Kumar

doi:10.25081/cb.2020.v11.6009

Cited by 7 publications

(7 citation statements)

References 44 publications

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“…A wide range of scavenging enzymes such as glutathione, NADH, NADPH, superoxide dismutase and catalase reacts with free radicals and protect the body against noxious oxidative stress, cellular and molecular damage (1). Disintegration of free radicals and scavengers balance may trigger various diseases such as neurodegenerative disease, Parkinson's, mongolism, cancer and the aging process (2,3). Antioxidant inhibits the initiation of oxidative chain reactions, which prevents the oxidation of lipids or other molecules by different mechanisms like free radicalscavenging, potential complexity of pro-oxidant metals and by single oxygen quenching (4).…”

Section: Introductionmentioning

confidence: 99%

Assessment of total phenolic content and antioxidant potentiality of selected Indian folk medicinal plants by spectrophotometric method

et al. 2020

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Natural antioxidant capacity of five important folk medicinal plants measured in vitro. Total phenolic content (TPC), flavonoid content (FC) and free radical scavenging capacity of ethanolic, methanolic and aqueous leaf extracts of Lippia alba (LA), Annona squamosa (AS), Hyptis suaveolens (HS), Commiphora wightii (CW) and Milletia pinnata (MP) was assessed using spectrophotometric method. Folin ciocalteu and aluminium chloride method employed to optimise TPC and FC. Free radical scavenging potentiality of leaf extracts was assessed using Ferrous ion chelation (FIC), 2, 2'-diphenyl-1-picrylhydrazyl (DPPH•) scavenging, Hydroxyl (OH•) radical scavenging (HRS) and Superoxide (O- 2) radical scavenging (SRS) methods. Results revealed that the TPC (96.22±5.85 to 519.23±34.90 μg GAE/gm dry weight) were found significant in aqueous extracts from all the plants except AS (p<0.05). For FC (μg QCE/gm dry weight), ethanol was found optimum for LA (463.94±6.49), CW (289.99±2.70) and MP (347.47±4.50) whereas, aqueous was found more appropriate for rest two plants were found significant instead of ethanol and methanol (all p<0.05). The lowest IC50 (μg/ml) were recorded from A. squamosa (27.72±8.95), H. suaveolens (27.78±0.88), C. wightii (27.18±0.16) and M. pinnata (27.30±0.03). All plants have reflected a high antioxidant capacity; however, the highest antioxidant activity was reported from ethanolic extract of H. suaveolens followed by L. alba, A. squamosa, C. wightii and M. pinnata. Hence, these studies show that all folk medicinal plants contain potential antioxidant bioactive compounds.

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Section: Introductionmentioning

confidence: 99%

Assessment of total phenolic content and antioxidant potentiality of selected Indian folk medicinal plants by spectrophotometric method

et al. 2020

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“…Owing to the high reactivity of hydrogen peroxide with metal ions, eg copper and iron, hydroxyl radicals are generated. 33 …”

Section: Resultsmentioning

confidence: 99%

“…Owing to the high reactivity of hydrogen peroxide with metal ions, eg copper and iron, hydroxyl radicals are generated. 33 The highest percentage hydrogen peroxide scavenging activity at 20 ppm was obtained in ascorbic acid (52.82 ±1.25), and the highest values at 40, 60, 80, and 100 ppm 3.…”

Section: Hydrogen Peroxide Scavenging Activitymentioning

confidence: 86%

Determination of Caffeine and Hydrogen Peroxide Antioxidant Activity of Raw and Roasted Coffee Beans Around Habru Woreda, Ethiopia Using UV-Vis Spectroscopy

Muhammed¹,

Seid²,

Habte³

2021

CPAA

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Background: Coffee is a well-known beverage that is widely used around the world. Despite the wide use of coffee in Ethiopia, there is a lack of extensive studies addressing the issues related to the caffeine content and hydrogen peroxide antioxidant activity of varieties of coffee types, particularly in Habru woreda, Ethiopia. Objective: This study aimed to determine the caffeine content and hydrogen peroxide antioxidant activity of raw and roasted coffee beans collected directly from Habru woreda, North Wollo zone of Ethiopia. Methods: The study was conducted in Bohoro, Girana, and Wurgisa kebeles of Habru woreda, Ethiopia, by collecting 500 g of green beans of Arabica coffee without considering their variety. Then, the collected beans were divided into raw and roasted coffee to perform aqueous and dichloromethane extraction of their caffeine content and hydrogen peroxide antioxidant activity using UV-Vis spectrophotometry. Results: The amounts of caffeine in aqueous and dichloromethane extraction were in the range of 124.01−191.27 ppm and 145.15−200.09 ppm in raw and roasted coffees, respectively. Using the IC 50 value, the hydrogen peroxide scavenging activity of the aqueous phase coffee bean extracts in Bohoro raw, Bohoro roasted, Wurgisa raw, Wurgisa roasted, Girana raw, and Girana roasted coffee were 32.17 ppm, 11.69 ppm, 26.14 ppm, 3.12 ppm, 24.83 ppm, and 11.06 ppm, respectively, while that of ascorbic acid was 6.91 ppm. Conclusion:The study showed that the highest amount of caffeine in both aqueous and dichloromethane solvent extraction was found in Bohoro's raw and roasted coffee beans. Also, the amounts of caffeine in all coffee bean samples were safe and the antioxidant activity was excellent. In most of the samples, significant variations in the concentration of caffeine in raw and roasted coffee bean samples were observed in the two extraction solvents.

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“…Although transition metals besides Fe +2 , e.g. Zn +2 , Cu +2 , and Mn +2 , could be complexed by compounds which have metal-chelating properties [41], the quantities of metal ions and phenolic compounds, and the differences in solubility of several foods and beverage sources of minerals could affect differently the complexation with transition metals [40,42,43]. Afsana and coauthors [42] showed an effect of ingesting tannic acid on the decrease of iron absorption, but not on the absorption of zinc, copper, and manganese.…”

Section: Discussionmentioning

confidence: 99%

Elevated Iron Chelating Activity of Ilex paraguariensis Leaf Infusion: in vitro and in vivo Pilot Studies

Pagliosa

Vieira

Silveira

et al. 2021

Braz. arch. biol. technol.

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This study presents an Ilex paraguariensis leaf infusion with important potential as natural ironchelating. The impact of infusion time and the water volume to obtain an Ilex paraguariensis leaf infusion with high phenolic content and iron chelating activity, such as the stability of these proprieties in the storage time and temperature (immediately and after 24 h at 8 and 25 C) were assessed. The acute consumption effect of this infusion to reduce iron absorption in vivo was also evaluated. A preliminary crossover trial with volunteers that ingested a meal containing non-haem iron (11.4 mg) with the treatments: Ilex paraguariensis leaf infusion with the highest phenolic content and iron chelating activity (200 mL) or control (200 mL water). Blood samples were withdrawn before and 1, 2, 3 and 4 h after the meal for serum iron measurement. The highest phenolic content (18.1 mg/mL) and iron chelating activity (100%) were observed for 10 min infusion time using 30 g leaves/300 mL water. Storage at 8 or 25 C for 24 h decreased total phenolics and dicaffeoylquinic acids by 23.5% and 25.5%, respectively (p< 0.05), without affecting the iron-chelating activity due to a saturating chelating effect at 3.34 mg/mL phenolic content. Inhibition of the iron absorption in vivo by infusion was 78% considering the iron recovery at peak maximum. The in vitro and preliminary in vivo results showed a functional property of the Ilex paraguariensis leaf infusion that may be useful for adjuvant management of iron overload diseases. Keywords: Ilex paraguariensis leaf infusion; iron chelating activity; phenolic compounds; in vitro and in vivo studies. HIGHLIGHTS Ilex paraguariensis infusion reaches elevated iron chelating potential. Storage for 24h decreases phenolic acids without affecting iron chelating activity. This infusion may be exploited as a natural iron chelating agent. 2 Pagliosa, C.M.; et al.

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Scavenging and metal chelating potential of Carthamus tinctorius L. extracts

Cited by 7 publications

References 44 publications

Assessment of total phenolic content and antioxidant potentiality of selected Indian folk medicinal plants by spectrophotometric method

Assessment of total phenolic content and antioxidant potentiality of selected Indian folk medicinal plants by spectrophotometric method

Determination of Caffeine and Hydrogen Peroxide Antioxidant Activity of Raw and Roasted Coffee Beans Around Habru Woreda, Ethiopia Using UV-Vis Spectroscopy

Elevated Iron Chelating Activity of Ilex paraguariensis Leaf Infusion: in vitro and in vivo Pilot Studies

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