SCC-Ag, lymph node metastases and sentinel node procedure in early stage squamous cell cervical cancer

Lande, Jonas van de; Davelaar, Elvira M.; Mensdorff‐Pouilly, Silvia von; Water, Tatjana J.; Berkhof, Johannes; Baal, W.M. van; Kenemans, P.; Verheijen, René H.M.

doi:10.1016/j.ygyno.2008.09.042

Cited by 39 publications

(36 citation statements)

References 25 publications

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“…In the last decade, several clinicopathological characteristics including higher stage [7], larger tumor size [7,17], LVSI [5,7,8], DSI [5,8,18], PI [17], and high serum squamous cell carcinoma antigens (SCCAg) [5,18,19] have been reported as predictors of LNM in cervical cancer. In the current study, univariate analysis indicated that DSI, tumor size > 2 cm, LVSI and PI were predictive factors for LNM.…”

Section: Discussionmentioning

confidence: 99%

Predictive Factors of Pelvic Lymph Node Metastasis in Early-Stage Cervical Cancer

Nanthamongkolkul

Hanprasertpong²

2018

Oncol Res Treat

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Background: Pelvic lymphadenectomy, which is the routine surgical treatment for early-stage cervical cancer, causes serious morbidity. The goal of the current retrospective study was to identify predictive factors of lymph node metastasis (LNM) in patients with early-stage cervical cancer. Patients and Methods: The study included 496 patients diagnosed with stages IA2-IB1cervical cancer who underwent a radical hysterectomy with pelvic lymphadenectomy. The predictive factors of LNM were evaluated. Results: The incidence of LNM in this study was 4.6%. LNM was more common in patients with deep stromal invasion (DSI), tumor size > 2 cm, lymph vascular invasion and parametrial involvement (PI). Multivariate analysis showed DSI (p = 0.010) and PI (p = 0.005) were independently associated with LNM. The median follow-up time was 56.9 months. The patients with LNM had poorer 5-year overall survival (77.8%; 95% confidence interval (CI) 44.2-92.6) than the patients without LNM (98.2%; 95% CI 95.6-99.2; p = 0.002) and also poorer 5-year recurrence-free survival (65.5%; 95% CI 38.6-82.8) than the patients without LNM (90.2%; 95% CI 86.5-92.9; p < 0.001). Conclusion: The predictive factors of pelvic lymph node metastasis in stage IA2-IB1 cervical cancer patients were DSI and PI. LNM was associated with poorer oncological outcomes.

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Section: Discussionmentioning

confidence: 99%

Predictive Factors of Pelvic Lymph Node Metastasis in Early-Stage Cervical Cancer

Nanthamongkolkul

Hanprasertpong²

2018

Oncol Res Treat

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“…The pathological response to GnRH agonist treatment was categorized as complete response (CR), partial response (PR), stable disease (16), or progressive disease (17) based on the previous report by Corzo et al (9). CR was defined as the absence of any hyperplastic or neoplastic lesion.…”

Section: Methodsmentioning

confidence: 99%

Fertility Sparing Treatment in Patients With Early Stage Endometrial Cancer, Using a Combination of Surgery and GnRH Agonist: A Monocentric Retrospective Study and Review of the Literature

et al. 2018

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Objectives: To evaluate the efficacy and safety of gonadotropin-releasing hormone (GnRH) agonist after endometrial resection in women suffering early stage endometrial carcinoma (EC) and/or endometrial intra-epithelial neoplasia (EIN).Design: A retrospective review of clinical files between January 1999 and December 2016.Setting: University hospital.Patients: Eighteen women younger than 41 years with grade 1 endometrial carcinoma (G1EC) and/or Endometrial intra-epithelial neoplasia (EIN). Interventions: All patients received GnRH agonist for 3 months after an endometrial resection combined with a laparoscopy to exclude concomitant ovarian tumor and/or other extra-uterine disease. The patient underwent a follow-up of 3 months interval with endometrial sampling by hysteroscopy.Main Outcome Measure(s): The recurrence rate and the pregnancy rate after fertility sparing treatment.Results: We identified 9 patients with EIN (50%), 7 patients with G1EC (38.9%), 1 with combined histology (5.5%), and 1 with G2EC (5.5%). After a median follow-up of 40.7 months, 12 patients conserved their uterus (66.7%), and 8 (53.3%) patients were pregnant with a total of 14 pregnancies among those who tried to become pregnant. We observed a complete response rate in 12 patients (66.7%) but 3 of these patients relapsed (25%). We also found a stable disease in 6 patients (33.3%).Conclusions: Compared with other fertility sparing treatments, GnRH agonist after surgery is an effective fertility-sparing strategy for women with EIN and/or G1EC. We recommend hysterectomy once a family has been completed even if the literature does not clearly lead to radical surgery.

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“…3 With the further study of SCCAg, it was found that SCCAg was not expressed in mesenchymal tissue, so it could be used as a marker for the detection of lymph node micrometastasis in squamous cell cancer. 4 To our knowledge, correlations between CK19 and SCCAg expression in lymph node and prognosis of cervical squamous cell carcinoma have not been reported up to date. The aim of the study is to determine the possible prognostic value of CK19 and SCCAg expression in histologically sentinel negative lymph node of patients with cervical squamous cell carcinoma.…”

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confidence: 92%

Prognostic Significance of Cytokeratin 19 and Squamous Cell Cancer Antigen in Histologically Negative Sentinel Lymph Nodes of Cervical Squamous Cell Carcinoma

Ren

Zhou²,

Shu³

et al. 2016

Int J Gynecol Cancer

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SCC-Ag, lymph node metastases and sentinel node procedure in early stage squamous cell cervical cancer

Cited by 39 publications

References 25 publications

Predictive Factors of Pelvic Lymph Node Metastasis in Early-Stage Cervical Cancer

Predictive Factors of Pelvic Lymph Node Metastasis in Early-Stage Cervical Cancer

Fertility Sparing Treatment in Patients With Early Stage Endometrial Cancer, Using a Combination of Surgery and GnRH Agonist: A Monocentric Retrospective Study and Review of the Literature

Prognostic Significance of Cytokeratin 19 and Squamous Cell Cancer Antigen in Histologically Negative Sentinel Lymph Nodes of Cervical Squamous Cell Carcinoma

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