SCE, X-radiation sensitivity and mutation rate in multiple sclerosis

Chromosomal Radiosensitivity in Secondary‐Progressive Multiple Sclerosis Patients

“…Gipps and Kidsan (1984) reported a significant increased sensitivity to c irradiation as measured by chromosomal aberration induction in a group of 40 patients. This observation was in contradiction with previous data of Seshadri et al (1983) on X-ray sensitivity. In the study of Sola et al (1989) who used cell survival and unscheduled DNA repair synthesis as endpoints no increased radiosensitivity was found in patients with MS.…”

“…The results obtained for the healthy group with the G2-phase assay are in accordance with previous data reported by the same laboratory , Vral et al 2002b. These data provide an intriguing picture of the radiation response in lymphocytes from multiple sclerosis patients and may in fact explain the contradictory findings reported in the literature (Seshadri et al 1983, Gipps and Kidson 1984, Sola et al 1989, Karaoulov et al 1995. That lymphocytes of MS patients have a better repair capacity, as observed with the LDR MN assay and the DRS index, confirms that the LDR MN assay may indeed be a more suitable/sensitive biomarker to identify small differences in repair capacity.…”

“…Increased spontaneous frequencies of chromosomal aberrations in peripheral blood lymphocytes (PBL) of MS patients have been reported (Seshadri et al 1983, Gipps and Kidsan 1984, Kä rki et al 1986, Senécal-Quevillon et al 1986). In the study of D' Alessandro et al (1990) an enhanced yield of cytogenetic abnormalities was correlated with the stage of the illness.…”

Cell-Mediated Immune Functions in Multiple Sclerosis

“…An interesting hypothesis put forth by Roos [1985] suggests that intrinsic B cell abnor malities such as DNA translocations or ab normal gene rearrangements could lead to B cell proliferation, increased immunoglobulin secretion and even immunodysregulation. Recent studies have shown genetic abnor malities in the MNC of MS patients; in creased sister-chromatid exchange [Karki et al, 1986;Seshadri et al, 1983] and an in creased sensitivity to ionising radiation [Gipps and Kidson, 1981] have been re ported. These abnormalities could lead to increased mutations in the B lymphocytes of MS patients.…”