Schiff base derived Mn(II) and Cd(II) novel complexes for catalytic and antioxidant applications

Janjua, Ubaid Ullah; Pervaiz, Muhammad; Ali, Faisal; Saleem, Aimon; Ashraf, Adnan; Younas, Umer; Iqbal, Munawar

doi:10.1016/j.inoche.2023.111233

Cited by 11 publications

(7 citation statements)

References 65 publications

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“…Similarly, the signal is observed in the downfield region of the spectrum due to the influence of the electron withdrawal effect arising from the nitrogen atom, which resulted in the deshielding of the proton and subsequently resonated at a higher frequency. Additionally, this proton is observed at a more downfield region compared to other azomethine protons that are usually seen at slightly above 8.00 ppm [27] . This is because the azomethine proton experiences the influence of three aromatic systems, which lead to a stronger deshielding effect.…”

Section: Resultsmentioning

confidence: 86%

“…After which, the absorbance of each mixture was measured using a spectrophotometer at 517 nm. Each measurement was carried out in triplicate, and the proportion of radical scavenging ability of the compounds was obtained using a standard equation [27] …”

Section: Methodsmentioning

confidence: 99%

“…The ability of the ligand (HL) and its complexes (C1-C3) to mop up free radicals was evaluated using a reported literature procedure. [27] The synthesized ligand, its complexes, and the control (ascorbic acid) were dissolved in DMSO, at concentration range of 62.5 to 1000 μg/mL. From these concentrations, 1 mL of each was reacted with a 3 mL methanolic solution of 0.1 mM DPPH.…”

Section: Antioxidant Evaluationmentioning

confidence: 99%

“…Each measurement was carried out in triplicate, and the proportion of radical scavenging ability of the compounds was obtained using a standard equation. [27]…”

Section: Antioxidant Evaluationmentioning

confidence: 99%

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Antioxidant Activity and DFT Calculations of Metal Complexes Derived from a Schiff Base Ligand: Synthesis, Characterization, and Biological Evaluation

Lawan,

Mshelia,

Mala

et al. 2024

ChemistrySelect

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Metal complexes derived from Schiff bases are known to have a wide range of applications, spanning the areas of material and medicinal sciences. Herein, a Schiff base ligand, (Z)‐2‐(((4‐chlorophenyl)imino)methyl)naphthalen‐1‐ol HL, was synthesized via a condensation reaction between 2‐hydroxy‐1‐naphthaldehyde and 4‐chloroaniline using methanol as a solvent in the presence of a catalytic amount of formic acid. The obtained ligand was further reacted with Mn(II), Ni(II), and Cu(II) using their acetate salts in a 1 : 2 stoichiometric ratio of metal to ligand to afford complexes C1–C3, respectively. Physicochemical and analytical techniques consisting of FTIR, UV‐Vis, elemental (CHN and metal content), TGA, HRMS, 1H, and 13 C NMR spectroscopy were deployed to establish the formation of the compounds. Results show that the ligand coordinated with the metal ions through the oxygen and nitrogen atoms of the phenolate and azomethine moieties, respectively, forming ON‐type complexes. Furthermore, the free ligand and its complexes were evaluated for their antioxidant activity compared to the standard (ascorbic acid) using an in vitro DPPH radical scavenging assay. From this investigation, C1 demonstrated higher radical scavenging activity than the free ligand, the complexes, and the standard (ascorbic acid). But the ligand has better scavenging activity than C2 and C3 at higher concentrations. DFT was also used to examine the electronic properties of the compounds, and the data obtained corroborated well with the experimental study.

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Section: Resultsmentioning

confidence: 86%

Section: Methodsmentioning

confidence: 99%

Section: Antioxidant Evaluationmentioning

confidence: 99%

“…Each measurement was carried out in triplicate, and the proportion of radical scavenging ability of the compounds was obtained using a standard equation. [27]…”

Section: Antioxidant Evaluationmentioning

confidence: 99%

See 2 more Smart Citations

Antioxidant Activity and DFT Calculations of Metal Complexes Derived from a Schiff Base Ligand: Synthesis, Characterization, and Biological Evaluation

Lawan,

Mshelia,

Mala

et al. 2024

ChemistrySelect

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“…They have the capacity to interact and react with biomolecules in distinctive ways and through diverse mechanisms of action because of these distinctive characteristics. 6 The structural, coordinating and biological properties of aminoguanidine-based metal complexes have not been explored well. Our continuous interest in the diverse coordination modes and biological potentials motivated us to design the Zn( ii ) and Cd( ii ) complexes of a nitrogen rich flexible ligand derived from 5-bromo salicylaldehyde.…”

Section: Introductionmentioning

confidence: 99%

An all-rounder aminoguanidine based ligand, its unusual anionic zinc(ii) and cadmium(ii) coordination complexes and their biological implications

Santu,

Hashim,

Manoj

2024

New J. Chem.

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Platinum (II) Schiff Base Complexes and their Effects on the Inhibition of Amyloid β_1–42 Aggregation

İrişli,

Günnaz,

Özcan

et al. 2024

Applied Organom Chemis

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For synthesizing metal–organic molecules with pro‐drug properties to prevent the accumulation of amyloid beta (Aβ1–42), which is a feature of neurodegenerative Alzheimer's disease, two new Schiff bases with imine/amine donors 2‐([3,3‐diphenylalidene]amino)‐N,N‐dimethylethane‐1‐amine and N,N‐dimethyl‐2‐([quinolin‐4‐ylmethylene]amino)ethane‐1‐amine, as well as their novel Pt (II) complexes (I and II), were synthesized and characterized via Fourier transform infrared spectroscopy, 1H‐ and 13C‐nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, and elemental analyses. The spectroscopic data has shown that the ligands are coordinated to the central atom in a chelating manner.Furthermore, the interaction between these complexes and Aβ1–42 was investigated using the electrochemical methods, square wave voltammetry and pencil graphite electrode, while monitoring the changes in the oxidation signal of the Try residue in Aβ1–42.The ability of the compounds to inhibit Aβ1–42 aggregation was investigated using the human neuroblastoma cell line (SH‐SY5Y). Complex II could actively inhibit the aggregation of Aβ1–42 at a molar ratio of 1.0/1.0, and its Aβ1–42 aggregation kinetics were fluorometrically determined using thioflavin T.These results were supported by scanning electron microscopy and transmission electron microscopy analyses. Moreover, the interaction of complex II with Aβ1–16 was investigated via 1H‐NMR spectroscopy.As a result, it was observed that complex II was effective in inhibiting the aggregation of Aβ1–42 at a molar ratio of 1.0/1.0. This result shows that studies can be conducted on the effects of Schiff base‐Pt complexes as potential pro‐drugs on Alzheimer's disease.

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Schiff base derived Mn(II) and Cd(II) novel complexes for catalytic and antioxidant applications

Cited by 11 publications

References 65 publications

Antioxidant Activity and DFT Calculations of Metal Complexes Derived from a Schiff Base Ligand: Synthesis, Characterization, and Biological Evaluation

Antioxidant Activity and DFT Calculations of Metal Complexes Derived from a Schiff Base Ligand: Synthesis, Characterization, and Biological Evaluation

An all-rounder aminoguanidine based ligand, its unusual anionic zinc(ii) and cadmium(ii) coordination complexes and their biological implications

Platinum (II) Schiff Base Complexes and their Effects on the Inhibition of Amyloid β_1–42 Aggregation

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Schiff base derived Mn(II) and Cd(II) novel complexes for catalytic and antioxidant applications

Cited by 11 publications

References 65 publications

Antioxidant Activity and DFT Calculations of Metal Complexes Derived from a Schiff Base Ligand: Synthesis, Characterization, and Biological Evaluation

Antioxidant Activity and DFT Calculations of Metal Complexes Derived from a Schiff Base Ligand: Synthesis, Characterization, and Biological Evaluation

An all-rounder aminoguanidine based ligand, its unusual anionic zinc(ii) and cadmium(ii) coordination complexes and their biological implications

Platinum (II) Schiff Base Complexes and their Effects on the Inhibition of Amyloid β1–42 Aggregation

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Product

Resources

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Platinum (II) Schiff Base Complexes and their Effects on the Inhibition of Amyloid β_1–42 Aggregation