Schiff base network-1 incorporated monolithic column for in-tube solid phase microextraction of antiepileptic drugs in human plasma

Latest Improvements and Expanding Applications of Solid-Phase Microextraction

“…A novel monolithic column incorporated with Schiff base network-1 (SNW-1) has been prepared for IT-SPME of antiepileptic drugs. 192 In addition to a monolithic column, the nanocomposite of molecularly imprinted polypyrrole on copper oxide (MIP@CuO) has been introduced as a new coating for IT-SPME. Due to the porous structure and high surface area of the prepared coating, selective extraction of carbamazepine in biological samples has been realized.…”

“…The materials fabricated in the tube are the keys to improve the enrichment efficiency. A novel monolithic column incorporated with Schiff base network-1 (SNW-1) has been prepared for IT-SPME of antiepileptic drugs . In addition to a monolithic column, the nanocomposite of molecularly imprinted polypyrrole on copper oxide (MIP@CuO) has been introduced as a new coating for IT-SPME.…”

Current trends in the development of polymer‐based monolithic stationary phases

“…As is the case in liquid chromatography‐based separations, modification of polymer monoliths with nanoparticles is also important in the development of materials for sample preparation methods. Wang et al 99 . described the preparation of a new monolithic column with the incorporation of Schiff base network‐1 (SNW‐1) nanoparticles for the extraction of antiepileptic drugs.…”

“…Wang et al. 99 described the preparation of a new monolithic column with the incorporation of Schiff base network‐1 (SNW‐1) nanoparticles for the extraction of antiepileptic drugs. The column was prepared by direct thermal copolymerization of the SNW‐1 nanoparticles together with GMA and EDMA in the presence of porogenic solvents and initiator.…”

Functionalized monolithic columns: Recent advancements and their applications for high-efficiency separation and enrichment in food and medicine

“…Their method achieved detection limits of 0.03 ng ml −1 and 0.30 ng ml −1 , respectively, and recovery rates of 90.5-93.1 and 93.3-96.0%, which effectively prevented the abuse of tramadol. (Wang R. et al, 2021) synthesized a monolithic column incorporating Schiff base network-1 (SNW-1), as shown in Figure 7B, and used it for the determination of three antiepileptic drugs (carbamazepine, oxcarbazepine, lamotrigine) in epilepsy patients, in order to solve the problem that the drug concentration in the plasma cannot be detected in time to prevent the adverse reactions caused by the narrow treatment range of antiepileptic drugs. Its detection limit was 0.2 ng ml −1 , and the recovery rate was in the range of 88.6-106.1%, indicating that the method has a good application prospect in the extraction and quantitative analysis of antiepileptic drugs.…”