Schisandrin B attenuates the inflammatory response, oxidative stress and apoptosis induced by traumatic spinal cord injury via inhibition of p53 signaling in adult rats

Xin, Danqing; Hu, Zicheng; Huo, Hongjun; Yang, Xiaojiao; Han, Dong‐Hai; Wu, Xing; Zhao, Yin; Qiu, Quanhe

doi:10.3892/mmr.2017.6622

Cited by 33 publications

(18 citation statements)

References 22 publications

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“…All rats were anesthetized with intraperitoneal 300 mg/kg chloral hydrate (Sigma-Aldrich; Merck KGaA, Darmstadt, Germany) and the T8-T10 spinal column was exposed. The Impact One™ Stereotaxic Impactor (Leica Microsystems GmbH, Wetzlar, Germany) was inserted through the atlanto-occipital membrane at T9 and was an SCI model was established as previously described (8). Rats of the sham group were anesthetized with intraperitoneal 300 mg/kg chloral hydrate (Sigma-Aldrich; Merck KGaA) without the induction of SCI.…”

Section: Animals and Treatments A Total Of 16 Adult Femalementioning

confidence: 99%

miRNA‑146a attenuates inflammation in an in�vitro spinal cord injury model via inhibition of TLR4 signaling

Tan

Zhang

et al. 2018

Exp Ther Med

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The present study evaluated the anti-inflammatory effect of microRNA (miR)-146a in a spinal cord injury (SCI) rat model and model, and explored possible underlying mechanisms of this effect. miR-146a expression was analyzed using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 content was measured using ELISA kits. Inducible nitric oxide synthase (iNOS), prostaglandin E2 (PGE2), Toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88) and phosphorylated (p)-nuclear factor (NF)-κB were measured using western blotting. In the SCI rat model, miR-146a expression was downregulated. In the model, downregulation of miR-146a increased inflammation, enhanced iNOS and PGE2 protein expression and induced TLR4, MyD88 and NF-κB expression. Overexpression of miR-146a reduced inflammation, iNOS and PGE2 protein expression, and suppressed TLR4, MyD88 and NF-κB expression in the SCI model. The inhibition of TLR4 attenuated the proinflammatory effects of anti-miR-146a in the SCI model. The results indicate that miR-146a reduces inflammation in an SCI model through the TLR4-NF-κB signaling pathway. The present study demonstrated that miR-146a may be a promising therapeutic agent for SCI.

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Section: Animals and Treatments A Total Of 16 Adult Femalementioning

confidence: 99%

miRNA‑146a attenuates inflammation in an in�vitro spinal cord injury model via inhibition of TLR4 signaling

Tan

Zhang

et al. 2018

Exp Ther Med

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“…Schisandrin B (Sch B) is a bioactive ingredient isolated from the plant, Schisandra chinensis (also known as the five-flavor berry or Wu Wei Zi). Several lines of evidence have shown that Sch B has anti-oxidative, anti-inflammatory, and anti-tumor activities [ 10 , 11 , 12 ]. Recent studies have shown that Sch B can be used as a treatment for bacterial or lipopolysaccharide-induced neuroinflammation [ 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice

et al. 2020

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Currently, Angiostrongylus cantonensis infections are predominantly treated with albendazole. However, the use of albendazole can provoke certain neurological symptoms as a result of the immune response triggered by the dead worms. Therefore, treatment usually involves co-administration of corticosteroids to limit the inflammatory reaction. Corticosteroids play a useful role in suppressing inflammation in the brain; however, long-term usage or high dosage may make it problematic.Schisandrin B, an active ingredient from Schisandra chinensis, has been shown to have anti-inflammatory effects on the brain. This study aimed to investigate the effects and potential of schisandrin B in combination with albendazole to treat Angiostrongylus-induced meningoencephalitis. Here, we show that albendazole-schisandrin B co-treatment suppressed neuroinflammation in Angiostrongylus-infected mice and increased the survival of the mice. Accordingly, albendazole-schisandrin B co-treatment significantly inhibited inflammasome activation, pyroptosis, and apoptosis. The sensorimotor functions of the mice were also repaired after albendazole-schisandrin B treatment. Immune response was shown to shift from Th2 to Th1, which reduces inflammation and enhances immunity against A. cantonensis. Collectively, our study showed that albendazole-schisandrin B co-therapy may be used as an encouraging treatment for Angiostrongylus-induced meningoencephalitis.

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“…The increase in vitamin C concentration in the liver of test animals upon treatment with γ‐schisandrin also validates its hepatoprotective ability. Another individual lignin, Schisandrin B was also found to counter oxidative harm to liver tissues (Thandavarayan et al, ; Xin et al, ). In one scientific study, the hepatoprotective mechanism against acetaminophen‐induced liver injury of six Schisandra lignans (deoxyschisandrin, Schisantherin A, Schisandrin B, Gomisin A, Schisandrin C, and schisandrin) was elucidated.…”

Section: Resultsmentioning

confidence: 99%

Selected hepatoprotective herbal medicines: Evidence from ethnomedicinal applications, animal models, and possible mechanism of actions

Ali

Khan

Fatima

et al. 2017

Phytotherapy Research

119

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Insight into the hepatoprotective effects of medicinally important plants is important, both for physicians and researchers. Main reasons for the use of herbal medicine include their lesser cost compared with conventional drugs, lesser undesirable drug reactions and thus high safety, and reduced side effects. The present review focuses on the composition, pharmacology, and results of experimental trials of selected medicinal plants: Silybum marianum (L.) Gaertn., Glycyrrhiza glabra, Phyllanthus amarus Schumach. & Thonn., Salvia miltiorrhiza Bunge., Astragalus membranaceus (Fisch.) Bunge, Capparis spinosa (L.), Cichorium intybus (L.), Solanum nigrum (L.), Sapindus mukorossi Gaertn., Ginkgo biloba (L.), Woodfordia fruticosa (L.) Kurz, Vitex trifolia (L.), Schisandra chinensis (Turcz.) Baill., Cuscuta chinensis (Lam.), Lycium barbarum, Angelica sinensis (Oliv.) Diels, and Litsea coreana (H. Lev.). The probable modes of action of these plants include immunomodulation, stimulation of hepatic DNA synthesis, simulation of superoxide dismutase and glutathione reductase to inhibit oxidation in hepatocytes, reduction of intracellular reactive oxygen species by enhancing levels of antioxidants, suppression of ethanol-induced lipid accumulation, inhibition of nucleic acid polymerases to downregulate viral mRNA transcription and translation, free radical scavenging and reduction of hepatic fibrosis by decreasing the levels of transforming growth factor beta-1, and collagen synthesis in hepatic cells. However, further research is needed to identify, characterize, and standardize the active ingredients, useful compounds, and their preparations for the treatment of liver diseases.

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Schisandrin B attenuates the inflammatory response, oxidative stress and apoptosis induced by traumatic spinal cord injury via inhibition of p53 signaling in adult rats

Cited by 33 publications

References 22 publications

miRNA‑146a attenuates inflammation in an in�vitro spinal cord injury model via inhibition of TLR4 signaling

miRNA‑146a attenuates inflammation in an in�vitro spinal cord injury model via inhibition of TLR4 signaling

Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice

Selected hepatoprotective herbal medicines: Evidence from ethnomedicinal applications, animal models, and possible mechanism of actions

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