Schistosoma Mansoni Colitis in AIDS Ga-67 Scintigraphic Findings

Chandramouly, Belur S.; Rabin, Gabriel E.; Schiano, Frank

doi:10.1097/00003072-199501000-00019

Cited by 5 publications

(2 citation statements)

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“…It would be important to rule out other concurrent comorbidities that could confound or worsen respiratory morbidity. In this review, smoking 18 , 48 and co-infections such as coccidiomycosis, tuberculosis, Human immunodeficiency virus infection and pneumonia 21 , 25 , 47 , 55 were reported in case reports.…”

Section: Discussionmentioning

confidence: 99%

Respiratory morbidity in Schistosoma mansoni infection: a rapid review of literature

Baluku,

Olum,

Sanya

et al. 2023

Therapeutic Advances in Infection

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Background: Schistosomiasis contributes to 2.5 million disability-adjusted life years globally. Acute and chronic respiratory morbidity of Schistosoma mansoni ( S. mansoni) is poorly documented in the literature. We conducted a rapid literature review of the burden of respiratory symptoms and lung function abnormalities among patients with S. mansoni. We also report the immunologic and lung imaging findings from the studies reviewed. Methods: We carried out a comprehensive literature search in Embase and MEDLINE from the inception of the databases to 13th March 2023. Results: A total of 2243 patients with S. mansoni were reported from 24 case reports, 11 cross-sectional studies, 7 case series, 2 cohort studies and 2 randomized controlled trials. The prevalence of any respiratory symptom was 13.3–63.3% (total number of patients studied, n = 149). The prevalence of the individual symptoms among patients with S. mansoni in whom respiratory symptoms were sought for was as follows: cough (8.3–80.6%, n = 338), dyspnea (1.7–100.0%, n = 200), chest pain (9.0–57.1%, n = 86), sputum production (20.0–23.3%, n = 30) and wheezing (0.0 – 20.0%, n = 1396). The frequency of the symptoms tended to be higher in acute schistosomiasis. Restrictive lung disease was prevalent in 29.0% (9/31). The commonest chest imaging findings reported were nodules (20–90%, n = 103) and interstitial infiltrates (12.5–23.0%, n = 89). Peripheral blood eosinophilia was prevalent in 72.0–100.0% of patients ( n = 130) with acute schistosomiasis and correlated with symptoms and imaging abnormalities. Three case reports in chronic S. mansoni reported elevated C-reactive protein, leucocyte, neutrophil and absolute eosinophil counts, eosinophil percentage, IgE and IgG4. Conclusion: There is a high prevalence of respiratory morbidity among patients with S. mansoni, particularly in the acute stage of the infection, although the studies are relatively small. Larger studies are needed to characterize respiratory morbidity in chronic schistosomiasis and determine the underlying clinical and immunological mechanisms.

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Section: Discussionmentioning

confidence: 99%

Respiratory morbidity in Schistosoma mansoni infection: a rapid review of literature

Baluku,

Olum,

Sanya

et al. 2023

Therapeutic Advances in Infection

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“…It has been previously reported that Schistosoma mansoni colitis and Echinococcus multilocularis are diagnosed by persistent colonic activity on 67 Ga scintigraphy. (Chandramouly et al, 1995;Inceboz et al, 2006b). In addition, some scintigraphic methods have been used in the diagnosis of different parasitic diseases such as Fasciola hepatica (Rivera and Bermudez, 1984), of T. spiralis (Inceboz et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Technetium-99m labeled Mebendazole and biodistribution in experimentally Trichinella spiralis-infected rats

et al. 2011

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The aim of this study was to localize the biodistribution of Technetium-99m ( 99m Tc) Mebendazole in experimentally Trichinella spiralis (T. spiralis)-infected rats. Localizing and distinguishing the ''T. spiralis'' in body sites are very important and life saving processes. Scintigraphic detections may help to determine the sites of trichinellosis infection. Twelve healthy female Wistar rats were infected via oral administration of infected muscle containing 750 to 1000 larvae. In this study, the antibiotic was labeled with Tc-99m, and 99m Tc-Mebendazole was assessed as an infection imaging agent in a rat model. 99m Tc-mebendazole was examined for localizing the normal, and inflamed with trichinellosis in rat muscle tissues after administrated 99m Tc-mebendazole via intravenous (IV) or oral gastric catheter, and also for differentiating them from each other. 99m Tc labeled mebendazole was retained in infectious areas. It was established that 99m Tc-mebendazole which was administrated via IV route has high organ restrain level. It was observed that 99m Tc-mebendazole uptake was high in tongue and diaphragm muscles of T. spiralis-infected rats after administration of radiolabeled mebendazole via either oral or IV routes. This study may be viewed as a basement of future studies on diagnosis of T. spiralis infection.

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The ability of67ga scintigraphy to detect the lesions ofEchinococcus multilocularis infection: Preliminary results

et al. 2006

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Schistosoma Mansoni Colitis in AIDS Ga-67 Scintigraphic Findings

Cited by 5 publications

References 0 publications

Respiratory morbidity in Schistosoma mansoni infection: a rapid review of literature

Respiratory morbidity in Schistosoma mansoni infection: a rapid review of literature

Technetium-99m labeled Mebendazole and biodistribution in experimentally Trichinella spiralis-infected rats

The ability of67ga scintigraphy to detect the lesions ofEchinococcus multilocularis infection: Preliminary results

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