Schistosomal glomerulopathy and changes in the distribution of histological patterns of glomerular diseases in Bahia, Brazil

dos-Santos, Washington L. C.; Sweet, Glória Maria Maranhão; Bahiense-Oliveira, Marilia; Rocha, Paulo Novis

doi:10.1590/s0074-02762011000700017

Cited by 20 publications

(14 citation statements)

References 19 publications

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“…Digestive anomalies are present in only 8–10% of Chagas disease patients and are characterized by a dilation of esophagus and/or colon (mega esophagus and/or mega colon) and also damage in the peripheral nerves. This might be due to either an increased antibody production and proliferative responses to peripheral myelin components72 or as a consequence of the damage due to deposits of ICs in the nerve tissue, as reported for other infectious diseases, such as filariasis and schistosomiasis74.…”

Section: Discussionmentioning

confidence: 88%

Immune complexes in chronic Chagas disease patients are formed by exovesicles from Trypanosoma cruzi carrying the conserved MASP N-terminal region

Lozano

Pablos

Longhi

et al. 2017

Sci Rep

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The exovesicles (EVs) are involved in pathologic host-parasite immune associations and have been recently used as biomarkers for diagnosis of infectious diseases. The release of EVs by Trypanosoma cruzi, the causative agent of Chagas disease, has recently been described, with different protein cargoes including the MASP multigene family of proteins MASPs are specific to this parasite and characterized by a conserved C-terminal (C-term) region and an N-terminal codifying for a signal peptide (SP). In this investigation, we identified immature MASP proteins containing the MASP SP in EVs secreted by the infective forms of the parasite. Those EVs are responsible for the formation of immune complexes (ICs) containing anti-MASP SP IgGs in patients with different (cardiac, digestive and asymptomatic) chronic Chagas disease manifestations. Moreover, purified EVs as well as the MASP SP inhibit the action of the complement system and also show a significant association with the humoral response in patients with digestive pathologies. These findings reveal a new route for the secretion of MASP proteins in T. cruzi, which uses EVs as vehicles for immature and misfolded proteins, forming circulating immune complexes. Such complexes could be used in the prognosis of digestive pathologies of clinical forms of Chagas disease.

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Section: Discussionmentioning

confidence: 88%

Immune complexes in chronic Chagas disease patients are formed by exovesicles from Trypanosoma cruzi carrying the conserved MASP N-terminal region

Lozano

Pablos

Longhi

et al. 2017

Sci Rep

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“…The immunological nature of glomerular involvement in schistosomiasis is well established [5] , [9] , [10] . The most frequently reported histological types are chronic membranoproliferative glomerulonephritis and focal segmental glomerulosclerosis, usually with nephrotic syndrome [11] , [12] , [13] , [14] . There are other important factors, in addition to parasite antigens, which seem to contribute to the pathogenesis of glomerular disease in schistosomiasis, such as the collateral circulation of the portal system due to the degree of hepatic involvement, the inefficiency of the hepatic macrophage system, the severity and duration of infestation, racial and genetic factors [13] , [15] .…”

Section: Introductionmentioning

confidence: 99%

Renal Function in Hepatosplenic Schistosomiasis – An Assessment of Renal Tubular Disorders

et al. 2014

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BackgroundRenal involvement in Schistosoma mansoni infection is not well studied. The aim of this study is to investigate the occurrence of renal abnormalities in patients with hepatosplenic schistosomiasis (HSS), especially renal tubular disorders.MethodsThis is a cross-sectional study with 20 consecutive patients with HSS followed in a medical center in Maceió, Alagoas, Brazil. Urinary acidification and concentration tests were performed using calcium chloride (CaCl2) after a 12-h period of water and food deprivation. The biomarker monocyte chemoattractant protein 1 (MCP-1) was quantified in urine. Fractional excretion of sodium (FENa+), transtubular potassium gradient (TTKG) and solute-free water reabsorption (TcH2O) were calculated. The HSS group was compared to a group of 17 healthy volunteers.ResultsPatients' mean age and gender were similar to controls. Urinary acidification deficit was found in 45% of HSS patients. Urinary osmolality was significantly lower in HSS patients (588±112 vs. 764±165 mOsm/kg, p = 0,001) after a 12-h period of water deprivation. TcH2O was lower in HSS patients (0.72±0.5 vs. 1.1±0.3, p = 0.04). Urinary concentration deficit was found in 85% of HSS patients. The values of MCP-1 were higher in HSS group than in control group (122±134 vs. 40±28 pg/mg-Cr, p = 0.01) and positively correlated with the values of microalbuminuria and proteinuria.ConclusionsHSS is associated with important kidney dysfunction. The main abnormalities found were urinary concentrating ability and incomplete distal acidification defect, demonstrating the occurrence of tubular dysfunction. There was also an increase in urinary MCP-1, which appears to be a more sensitive marker of renal damage than urinary albumin excretion rate.

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“…Apparently due to the greater occurrence of subclinical disease in patients with S. hematobium, a higher prevalence of glomerular disease is often reported in those infected with S. mansoni (Tables 1, 2) [25][26][27]. SGN manifests as a clinical, spectrum of asymptomatic, proteinuria, nephrosis and/or nephritic syndrome.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

“…The most common category is Class I SGN and it is characterized by mesangial proliferative histology. Infected individuals are often asymptomatic (60 %) [26]. Class II SGN is an exudative proliferative lesion that occurs in response to Salmonella bacteria superinfection.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Urinary schistosomiasis

Bamgbola

2014

Pediatr Nephrol

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Schistosomal glomerulopathy and changes in the distribution of histological patterns of glomerular diseases in Bahia, Brazil

Cited by 20 publications

References 19 publications

Immune complexes in chronic Chagas disease patients are formed by exovesicles from Trypanosoma cruzi carrying the conserved MASP N-terminal region

Immune complexes in chronic Chagas disease patients are formed by exovesicles from Trypanosoma cruzi carrying the conserved MASP N-terminal region

Renal Function in Hepatosplenic Schistosomiasis – An Assessment of Renal Tubular Disorders

Urinary schistosomiasis

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